As there is a need to combat human diseases, many drugs are being used in the medical field. Though these drugs control the disease, when used in higher doses they may be toxic to the genetic system of human beings. Antihypertensive drugs are the most widely prescribed medications in the world. The duration of the pharmacological treatment of hypertension may last for decades and, therefore, patients are exposed to prolonged contact with these drugs. Long-term treatments require documentation of long-term safety and efficacy, including sensitive indices of genotoxic damage. Important part of prescription for hypertensive patients is Aliskiren, the third-generation renin inhibitor, prescribe for patient of hypertension. However the present topic is to understand the possible genotoxic effects of its long term use. This scientific information makes the people aware to utilize drug in preventive dose regimen and may be of interest to many pharmaceutical companies, bulk pharmaceuticals and drug authorities. The financial assistance received from the Gujarat Council on Science and Technology (GUJCOST), Gandhinagar, Gujarat, India to carry out this particular study is duly acknowledged.

Road traffic injuries account for 2.1% of global mortality. The developing countries bear a large share of burden and account for about 85% of the deaths as a result of road traffic crashes. 2] India accounts for about 10% of road accident fatalities worldwide. 3] Road accident contributed 30.2% to all kind of natural and unnatural accidental deaths during 2005 4]. According to the Institute of Road Traffic Education (2006) New Delhi, out of the estimated 1.4 million serious road accidents/ collisions occurring annually in India, hardly 0.4 million are recorded. 5] This indicates that the surveillance system for vehicular accidents is not well established in India. Epidemiological data on road traffic accidents in India have been reported but there is no proper correlation with head injury. The study correlating head injury with road traffic accidents in Delhi was done in 1979 since then there have been significant social and demographic changes including changes in life style, population and number of vehicles. Continuous growth in number of motor vehicles, increase in population and poor access to health care are some of the important factors in fatalities.