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With the prevalence of neurodegenerative diseases on the rise as
average life expectancy increases, the hunt for effective
treatments and preventive measures for these disorders is a
pressing challenge. Neurodegenerative disorders such as Alzheimer's
disease, Huntington's disease, Parkinson's disease and amyotrophic
lateral sclerosis have been termed 'protein misfolding disorders'
that are char- terized by the neural accumulation of protein
aggregates. Manipulation of the cellular stress response involving
the induction of heat shock proteins offers a the- peutic strategy
to counter conformational changes in neural proteins that trigger
pathogenic cascades resulting in neurodegenerative diseases. Heat
shock proteins are protein repair agents that provide a line of
defense against misfolded, aggregati- prone proteins. Heat Shock
Proteins and the Brain: Implications for Neurodegenerative Diseases
and Neuroprotection reviews current progress on neural heat shock
proteins (HSP) in relation to neurodegenerative diseases (Part I),
neuroprotection (Part II), ext- cellular HSP (Part III) and aging
and control of life span (Part IV). Key basic and clinical research
laboratories from major universities and hospitals around the world
contribute chapters that review present research activity and
importantly project the field into the future. The book is a must
read for researchers, postdoctoral fellows and graduate students in
the fields of Neuroscience, Neurodegenerative Diseases, Molecular
Medicine, Aging, Physiology, Pharmacology and Pathology.
With the prevalence of neurodegenerative diseases on the rise as
average life expectancy increases, the hunt for effective
treatments and preventive measures for these disorders is a
pressing challenge. Neurodegenerative disorders such as Alzheimer's
disease, Huntington's disease, Parkinson's disease and amyotrophic
lateral sclerosis have been termed 'protein misfolding disorders'
that are char- terized by the neural accumulation of protein
aggregates. Manipulation of the cellular stress response involving
the induction of heat shock proteins offers a the- peutic strategy
to counter conformational changes in neural proteins that trigger
pathogenic cascades resulting in neurodegenerative diseases. Heat
shock proteins are protein repair agents that provide a line of
defense against misfolded, aggregati- prone proteins. Heat Shock
Proteins and the Brain: Implications for Neurodegenerative Diseases
and Neuroprotection reviews current progress on neural heat shock
proteins (HSP) in relation to neurodegenerative diseases (Part I),
neuroprotection (Part II), ext- cellular HSP (Part III) and aging
and control of life span (Part IV). Key basic and clinical research
laboratories from major universities and hospitals around the world
contribute chapters that review present research activity and
importantly project the field into the future. The book is a must
read for researchers, postdoctoral fellows and graduate students in
the fields of Neuroscience, Neurodegenerative Diseases, Molecular
Medicine, Aging, Physiology, Pharmacology and Pathology.
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