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"Electrical Disease of the Heart, 2nd Edition, volume 2, "
covers the diagnostic and treatment options available in the
management of electrical diseases and with its companion volume
provides the latest developments in the field of experimental and
clinical cardiac electrophysiology, genetics, pharmacology and
interventional therapies of various clinical arrhythmogenic
entities. This bookis highly relevant to a broad audience, ranging
from medical and graduate students, to clinicians and
scientists."
A comprehensive review of all the latest developments in cardiac
electrophysiology, focusing on both the clinical and experimental
aspects of ventricular repolarization, including newly discovered
clinical repolarization syndromes, electrocardiographic phenomena,
and their correlation with the most recent advances in basic
science. The authors illuminate the basic electrophysiologic,
molecular, and pharmacologic mechanisms underlying ventricular
repolarization, relate them to specific disease conditions, and
examine the future of antiarrhythmic drug development based on both
molecular and electrophysiological properties. They also fully
review the clinical presentation and management of specific cardiac
repolarization conditions.
It is generally easy to define the efficacy of a new the- peutic
agent. However, what is even more difficult and more challenging
yet more important is to define its safety when administered to
millions of patients with multi-faceted d- eases, co-morbidities,
sensitivities and concomitant medi- tions. The commonest cause of
new drug discontinuations, cause for disapproval from marketing and
removal from the market after approval is a drug's effect on
cardiac repolari- tion which is essentially identified by
increasing the duration of the QTc interval duration on the
standard 12-lead elect- cardiogram (ECG). Cardiac Safety of
Noncardiac Drugs: Practical Guide- Joel Morganroth, MD lines for
Clinical Research and Drug Development is designed to present the
current preclinical, clinical, and re- latory principles to assess
the cardiac safety of new drugs based primarily on their effects on
the ECG. Practical gu- ance to define cardiac safety at all stages
of clinical research and drug development are featured and
discussed by inter- tionally recognized experts with academic,
industrial, and regulatory experience. Each chapter contains the
best ava- able evidence, the author's personal opinions, areas of
c- troversy, and future trends. Although some of the areas are
highly specialized, this book has been designed for a broad
audience ranging from medical and graduate students to cli- cal
nurses, clinical trial coordinators, safety officers, data
managers, statisticians, regulatory authorities, clinicians, and
Ihor Gussak, MD, PhD scientists.
Electrical Disease of the Heart, 2nd Edition, volume 1, provides a
valuable insight to the latest developments in the field of cardiac
electrophysiology and clinical electrocardiology. Each chapter
includes up-to-date results of studies aimed at providing an
understanding of the electrical function of the heart in health and
disease, established and evidence-based knowledge of clinical
outcomes, areas of controversy, and future trends. This book is
highly relevant to a broad audience, ranging from medical and
graduate students, to clinicians and scientists.
Electrical Disease of the Heart, 2nd Edition, volume 2, covers the
diagnostic and treatment options available in the management of
electrical diseases and with its companion volume provides the
latest developments in the field of experimental and clinical
cardiac electrophysiology, genetics, pharmacology and
interventional therapies of various clinical arrhythmogenic
entities. This book is highly relevant to a broad audience, ranging
from medical and graduate students, to clinicians and scientists.
About This Book Iatrogenesis is the occurrence of untoward effects
resulting from actions of health care providers, including medical
errors, medical malpractice, practicing beyond one's expertise,
adverse effects of medication, unnecessary treatment, inappropriate
screenings, and surgical errors. This is a huge public health
issue: tens to hundreds of thousands of deaths are attributed to
iatrogenic causes each year in the US, and vulnerable populations
such as the elderly and minorities are particularly susceptible.
Edited by two renowned cardiology experts, Iatrogenicity: Causes
and Consequences of Iatrogenesis in Cardiovascular Medicine
addresses both the iatrogenicity that arises with cardiovascular
interventions, as well as non-cardiovascular interventions that
result in adverse consequences on the cardiovascular system. The
book aims to achieve three things: to summarize the available
information on this topic in a single high-yield volume; to
highlight the human and financial cost of iatrogenesis; and to
describe and propose potential interventions to ameliorate the
effects of iatrogenesis. This accessible book is a practical
reference for any practicing physician who sees patients with
cardiovascular issues.
A comprehensive review of all the latest developments in cardiac
electrophysiology, focusing on both the clinical and experimental
aspects of ventricular repolarization, including newly discovered
clinical repolarization syndromes, electrocardiographic phenomena,
and their correlation with the most recent advances in basic
science. The authors illuminate the basic electrophysiologic,
molecular, and pharmacologic mechanisms underlying ventricular
repolarization, relate them to specific disease conditions, and
examine the future of antiarrhythmic drug development based on both
molecular and electrophysiological properties. They also fully
review the clinical presentation and management of specific cardiac
repolarization conditions.
Iatrogenesis is the occurrence of untoward effects resulting from
actions of health care providers, including medical errors, medical
malpractice, practicing beyond one's expertise, adverse effects of
medication, unnecessary treatment, inappropriate screenings, and
surgical errors. This is a huge public health issue: tens to
hundreds of thousands of deaths are attributed to iatrogenic causes
each year in the US, and vulnerable populations such as the elderly
and minorities are particularly susceptible. Edited by two renowned
cardiology experts, Iatrogenicity: Causes and Consequences of
Iatrogenesis in Cardiovascular Medicine addresses both the
iatrogenicity that arises with cardiovascular interventions, as
well as non-cardiovascular interventions that result in adverse
consequences on the cardiovascular system. The book aims to achieve
three things: to summarize the available information on this topic
in a single high-yield volume; to highlight the human and financial
cost of iatrogenesis; and to describe and propose potential
interventions to ameliorate the effects of iatrogenesis. This
accessible book is a practical reference for any practicing
physician who sees patients with cardiovascular issues.
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