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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Cardiac Safety of Noncardiac Drugs - Practical Guidelines for Clinical Research and Drug Development (Hardcover, 2005 ed.)
Loot Price: R4,405
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Cardiac Safety of Noncardiac Drugs - Practical Guidelines for Clinical Research and Drug Development (Hardcover, 2005 ed.)
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It is generally easy to define the efficacy of a new the- peutic
agent. However, what is even more difficult and more challenging
yet more important is to define its safety when administered to
millions of patients with multi-faceted d- eases, co-morbidities,
sensitivities and concomitant medi- tions. The commonest cause of
new drug discontinuations, cause for disapproval from marketing and
removal from the market after approval is a drug's effect on
cardiac repolari- tion which is essentially identified by
increasing the duration of the QTc interval duration on the
standard 12-lead elect- cardiogram (ECG). Cardiac Safety of
Noncardiac Drugs: Practical Guide- Joel Morganroth, MD lines for
Clinical Research and Drug Development is designed to present the
current preclinical, clinical, and re- latory principles to assess
the cardiac safety of new drugs based primarily on their effects on
the ECG. Practical gu- ance to define cardiac safety at all stages
of clinical research and drug development are featured and
discussed by inter- tionally recognized experts with academic,
industrial, and regulatory experience. Each chapter contains the
best ava- able evidence, the author's personal opinions, areas of
c- troversy, and future trends. Although some of the areas are
highly specialized, this book has been designed for a broad
audience ranging from medical and graduate students to cli- cal
nurses, clinical trial coordinators, safety officers, data
managers, statisticians, regulatory authorities, clinicians, and
Ihor Gussak, MD, PhD scientists.
General
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