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This book provides a groundbreaking introduction to the likelihood
inference for correlated survival data via the hierarchical (or h-)
likelihood in order to obtain the (marginal) likelihood and to
address the computational difficulties in inferences and
extensions. The approach presented in the book overcomes
shortcomings in the traditional likelihood-based methods for
clustered survival data such as intractable integration. The text
includes technical materials such as derivations and proofs in each
chapter, as well as recently developed software programs in R
("frailtyHL"), while the real-world data examples together with an
R package, "frailtyHL" in CRAN, provide readers with useful
hands-on tools. Reviewing new developments since the introduction
of the h-likelihood to survival analysis (methods for interval
estimation of the individual frailty and for variable selection of
the fixed effects in the general class of frailty models) and
guiding future directions, the book is of interest to researchers
in medical and genetics fields, graduate students, and PhD (bio)
statisticians.
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Rudie van Rensburg
Paperback
R454
Discovery Miles 4 540
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