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This interdisciplinary thesis introduces a systems biology approach
to study the cell fate decision mediated by autophagy. A
mathematical model of interaction between Autophagy and Apoptosis
in mammalian cells is proposed. In this dynamic model autophagy
acts as a gradual response to stress (Rheostat) that delays the
initiation of bistable switch of apoptosis to give the cells an
opportunity to survive. The author shows that his dynamical model
is consistent with existing quantitative measurements of time
courses of autophagic responses to cisplatin treatment. To
understand the function of this response in cancer cells, he has
provided a systems biology experimental framework to study
quantitative and dynamical aspects of autophagy in single cancer
cells using live-cell imaging and quantitative fluorescence
microscopy. This framework can provide new insights on function of
autophagic response in cancer cells.
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Wind and Leaf (Paperback)
Paul Cronin, Iman Tavassoly; Abbas Kiarostami
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R1,649
Discovery Miles 16 490
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Ships in 10 - 15 working days
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With the Wind (Hardcover)
Paul Cronin, Iman Tavassoly; Abbas Kiarostami
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R1,364
Discovery Miles 13 640
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Ships in 10 - 15 working days
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