Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells - Mathematical Modeling and Experimental Observations (Hardcover, 2015 ed.)

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	February 2015
First published:	2015
Authors:	Iman Tavassoly
Dimensions:	235 x 155 x 8mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	79
Edition:	2015 ed.
ISBN-13:	978-3-319-14961-5
Categories:	Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Professional & Technical > Mechanical engineering & materials > Materials science > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-319-14961-X
Barcode:	9783319149615

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