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Kisspeptin is a key player and regulator of reproduction and exerts
profound effects on male reproductive processes. Degenerative
effects of critical regulators of reproduction, the kisspeptin
peptides, on cellular aspects of sexually immature male gonads are
known but similar information on accessory sex glands remain
elusive. This book, therefore, assess the effects of kisspeptin
treatment by evaluating the cellular architecture at the light and
electron microscopic level and by determining the height of
epithelium in seminal vesicles. In addition DNA damage was analyzed
by DNA ladder assay and DNA fragmentation assay. Kisspeptin-10
exerted a pronounced inhibitory effect on seminal vesicles. It
reduced the height of epithelium and weight of seminal vesicles and
caused considerable DNA damage. Light microscopic examination
evidenced dilatation of the lumen and lack of intricate epithelial
folds. Ultrastructural changes included dilatation of the
endoplasmic reticulum and Golgi cisterns, a reduction of secretory
vesicles and the appearance of autophagic vacuoles. This is the
preliminary study of the effect of kisspeptin on seminal vesicles.
Toxicity due to heavy metals is of major concern in Pakistan.
Mercury, cadmium, chromium, arsenic, lead, zinc and copper
concentrations have increased to alarming levels in the water, soil
and air which have become large dumps of industrial effluents.
Physiologically, heavy metals can profoundly affect the functioning
of the endocrine system and in Pakistan, thyroid related diseases
are also very common. Chromium in hexavalent form is highly toxic
and a known carcinogen, however as opposed to the trivalent form,
its toxic effects on the thyroid structure and function are
relatively unexplored. Acute exposure to chromium (VI) can occur in
the occupational set up. The present study, therefore, investigated
the thyroid gland structure and function following intraperitoneal
administration of potassium dichromate (Cr-VI) in laboratory
rats.Diverse techniques were employed during the study. The results
give an insight to the toxic effects of hexavalent chromium on the
thyroid gland and describe how the metal interferes with the
functioning of the gland; not only with its morphology but also at
cellular and molecular levels.
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