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The innate immune system represents a critical arm of the immune
response by providing immediate and robust host defense; however,
human studies of its function are often limited by ethical,
logistical, and technical obstacles. In Mouse Models of Innate
Immunity: Methods and Protocols, experts in the field explore the
design and execution of experiments used to thoroughly evaluate
critical elements associated with the host innate immune response.
The volume opens with methods that are essential for collecting and
assessing various primary cells that are highly relevant to innate
immunity, and it continues with in vivo protocols commonly used to
evaluate the innate immune response in the mouse, including mouse
models of respiratory infection, gastrointestinal inflammation,
fungal and parasitic diseases, sepsis, and HIV-1 infection. Written
in the highly successful Methods in Molecular Biology series
format, chapters include introductions to their respective topics,
lists of the necessary materials and reagents, step-by-step,
readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls. Authoritative and easy
to use, Mouse Models of Innate Immunity: Methods and Protocols will
serve the research community by providing expert advice and
protocols that allow both experienced and novice investigators to
successfully plan, implement, and assess disease processes
associated with the innate immune response.
Over the last half century, a dramatic increase in allergic
diseases has been observed throughout industrialized nations, which
has resulted in significant worldwide socio-economic challenges. In
Mouse Models of Allergic Disease: Methods and Protocols, a wide
range of expert contributors provide detailed protocols for the
design and execution of experiments to thoroughly analyze critical
elements associated with a diverse range of allergic diseases, all
through the lens of mouse models that accurately recapitulate
clinically relevant aspects of the respective human disease. The
volume opens with a section featuring techniques essential for
effective ex vivo cell isolation and evaluation of specific cell
types relevant to a diverse range of allergic diseases, and the
book then moves on to cover in vivo protocols to evaluate prevalent
mouse models of human allergic diseases, including mouse models of
systemic anaphylaxis, contact hypersensitivity, allergic rhinitis,
and asthma, as well as a collection of chapters on in vivo and ex
vivo protocols used to assess indirect mediators of allergic
diseases, such as the nervous system, non-hematopoietic cells, and
the composition of the gut microbiome. Written in the highly
successful Methods in Molecular Biology series, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Timely and authoritative, Mouse Models of Allergic
Disease: Methods and Protocols serves as an essential collection of
protocols that allow both novice and expert researchers the ability
to accurately develop, evaluate, and characterize the mechanisms
associated with these disorders.
Over the last half century, a dramatic increase in allergic
diseases has been observed throughout industrialized nations, which
has resulted in significant worldwide socio-economic challenges. In
Mouse Models of Allergic Disease: Methods and Protocols, a wide
range of expert contributors provide detailed protocols for the
design and execution of experiments to thoroughly analyze critical
elements associated with a diverse range of allergic diseases, all
through the lens of mouse models that accurately recapitulate
clinically relevant aspects of the respective human disease. The
volume opens with a section featuring techniques essential for
effective ex vivo cell isolation and evaluation of specific cell
types relevant to a diverse range of allergic diseases, and the
book then moves on to cover in vivo protocols to evaluate prevalent
mouse models of human allergic diseases, including mouse models of
systemic anaphylaxis, contact hypersensitivity, allergic rhinitis,
and asthma, as well as a collection of chapters on in vivo and ex
vivo protocols used to assess indirect mediators of allergic
diseases, such as the nervous system, non-hematopoietic cells, and
the composition of the gut microbiome. Written in the highly
successful Methods in Molecular Biology series, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Timely and authoritative, Mouse Models of Allergic
Disease: Methods and Protocols serves as an essential collection of
protocols that allow both novice and expert researchers the ability
to accurately develop, evaluate, and characterize the mechanisms
associated with these disorders.
The innate immune system represents a critical arm of the immune
response by providing immediate and robust host defense; however,
human studies of its function are often limited by ethical,
logistical, and technical obstacles. In Mouse Models of Innate
Immunity: Methods and Protocols, experts in the field explore the
design and execution of experiments used to thoroughly evaluate
critical elements associated with the host innate immune response.
The volume opens with methods that are essential for collecting and
assessing various primary cells that are highly relevant to innate
immunity, and it continues with in vivo protocols commonly used to
evaluate the innate immune response in the mouse, including mouse
models of respiratory infection, gastrointestinal inflammation,
fungal and parasitic diseases, sepsis, and HIV-1 infection. Written
in the highly successful Methods in Molecular Biology series
format, chapters include introductions to their respective topics,
lists of the necessary materials and reagents, step-by-step,
readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls. Authoritative and easy
to use, Mouse Models of Innate Immunity: Methods and Protocols will
serve the research community by providing expert advice and
protocols that allow both experienced and novice investigators to
successfully plan, implement, and assess disease processes
associated with the innate immune response.
This second edition presents methods and protocols to aid readers
in the design and execution of experiments used to define critical
elements associated with innate immune system function. New and
updated chapters detail protocols on in vitro and ex vivo studies
in key cell types associated with innate immunity and with in vivo
protocols used to study immune system function in the mouse.
Additionally, chapters describe methods to evaluate innate immune
function and new protocols associated with autism, cancer,
microfluidics platforms, and CRISPR systems. Written in the highly
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Authoritative and easy to use, Mouse
Models of Innate Immunity: Methods and Protocols, Second Edition
will serve the research community by providing expert advice and
protocols that allow both experienced and novice investigators to
successfully plan, implement, and assess disease processes
associated with the innate immune system.
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