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Concepts in Toxicology (Hardcover)
John H. Duffus, Douglas M Templeton, Monica Nordberg; Contributions by Iupac, John W. Lorimer
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R1,803
Discovery Miles 18 030
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Ships in 12 - 17 working days
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Toxicology has never been more important. Advances in chemistry and
technology offering improvements in the quality of human life
become ever more rapid, bringing with them the potential for new
toxicity hazards. This has led to legislation requiring toxicity
testing and risk assessment for all chemicals and their uses. The
new REACH (Risk Evaluation and Authorization of Chemicals)
Regulation has profound economic consequences because, without
official authorization, a chemical cannot be marketed. This book
explains, in depth, the ideas underlying current advances in
toxicology and its application in regulating and ensuring the safe
use of chemicals. Sometimes old ideas have become assumptions that
have become embedded in related laws and regulation, even though
the thinking of toxicologists has moved on in line with
developments in science. This leads to confusion in public
understanding that the book should dispel. There are also
fundamental ideas in toxicology that are not well understood
concerning the concepts of hazard and risk and even about what
constitutes a chemical. For many people the word 'chemical'
describes manmade substances only. In fact, it is correctly applied
to all substances that exist, from pure elements to the most
complex biological molecules in food and medicines. This is further
complicated by the complex distinction between the descriptors,
'toxic' and 'nontoxic'. Developments in epigenetics are
revolutionizing our understanding of mutagenicity and
carcinogenicity. Improved understanding of apoptosis and necrosis
leads to improved interpretation of potentially toxic effects at
the cellular level. The recently defined term 'chemical speciation'
is driving more targeted research on the toxicity of inorganic
chemicals. This book explains the concepts implied by key
toxicological terms using diagrams to illustrate the relationships
between them. It is an essential aid to understanding the new
demands from regulators of risk assessment and to the
implementation of appropriate risk management.
Responsible Care - A Case Study is the first book of its kind to
provide insight into the development and evolution of Responsible
Care and its influence of societal outcomes on the basis of case
studies. It provides readers in industry, government, and academia
with the principles and innovative thinking associated with the
Responsible Care ethic as a means to promote and implement such
advanced concepts in their own institution. The book is not only a
teaching aid for university curriculum, it also serves as a
practical tool to industrial management and staff to improve
industrial policies. The last chapter illustrates a practical
example of a workshop held at McMaster University, Canada, which
can be used as a model for readers to use this book as an
educational tool.
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