The new field of physical biology fuses biology and physics. New technologies have allowed researchers to observe the inner workings of the living cell, one cell at a time. With an abundance of new data collected on individual cells, including observations of individual molecules and their interactions, researchers are developing a quantitative, physics-based understanding of life at the molecular level. They are building detailed models of how cells use molecular circuits to gather and process information, signal to each other, manage noise and variability, and adapt to their environment. This book narrows down the scope of physical biology by focusing on the microbial cell. It explores the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at the microbe from a physics perspective, to ask how the cell optimizes its function to live within the constraints of physics. It introduces a physical and information based -- as opposed to microbiological -- perspective on communication and signaling between microbes. The book is aimed at non-expert scientists who wish to understand some of the most important emerging themes of physical biology, and to see how they help us to understand the most basic forms of life.

Mistakes are unavoidable. Yet in most organizations, they are rarely thoroughly examined. An exception is the high-risk aviation industry, where experts have established an open and democratic culture for dealing with error.
Confronting Mistakes draws on this expertise to initiate a new framework for active error management relevant to wider industry. By analyzing dramatic aviation accidents, Jan Hagen presents a new approach to error management in business to reveal how diagnostic, error-permissive behaviour is the first step towards turning mistakes into learning opportunities.

Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication."

Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication.

In most organizations, errors - although common and unavoidable - are rarely mentioned bottom-up. Using this example of the high risk aviation industry this book assess how active error management can work and lead to success. Using academic research and 10 actual aviation accidents cases, this book will provide compelling and informative reading.

Now in it's 3rd Edition, Industrial Catalysis offers all relevant information on catalytic processes in industry, including many recent examples. Perfectly suited for self-study, it is the ideal companion for scientists who want to get into the field or refresh existing knowledge. The updated edition covers the full range of industrial aspects, from catalyst development and testing to process examples and catalyst recycling. The book is characterized by its practical relevance, expressed by a selection of over 40 examples of catalytic processes in industry. In addition, new chapters on catalytic processes with renewable materials and polymerization catalysis have been included. Existing chapters have been carefully revised and supported by new subchapters, for example, on metathesis reactions, refinery processes, petrochemistry and new reactor concepts. "I found the book accesible, readable and interesting - both as a refresher and as an introduction to new topics - and a convenient first reference on current industrial catalytic practise and processes." Excerpt from a book review for the second edition by P. C. H. Mitchell, Applied Organometallic Chemistry (2007)

The new field of physical biology fuses biology and physics. New technologies have allowed researchers to observe the inner workings of the living cell, one cell at a time. With an abundance of new data collected on individual cells, including observations of individual molecules and their interactions, researchers are developing a quantitative, physics-based understanding of life at the molecular level. They are building detailed models of how cells use molecular circuits to gather and process information, signal to each other, manage noise and variability, and adapt to their environment. This book narrows down the scope of physical biology by focusing on the microbial cell. It explores the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at the microbe from a physics perspective, to ask how the cell optimizes its function to live within the constraints of physics. It introduces a physical and information based - as opposed to microbiological - perspective on communication and signaling between microbes. The book is aimed at non-expert scientists who wish to understand some of the most important emerging themes of physical biology, and to see how they help us to understand the most basic forms of life.

"Come play inside me." The words emanate from the closet door under the basement, and when Wally goes inside, he starts to daydream about a land where the trees are made of cotton candy and the clouds are made of popcorn. All of a sudden, the closet begins to shake and seems to lift off the ground, and when Wally opens the door, he steps out into a world made of candy and sweets. "Welcome to Ecandy. My name is Eatalot," says a friendly green monster. "As you can see, "our trees are made of cotton candy, the sun is a big lemon drop, and our roads are made of bubblegum." It sounds too good to be true until Eatalot tells Wally that his people are suffering from poor health: Their teeth are rotting, their tummies are hurting, and they don't have enough strength to run and play. Fortunately, Wally remembers learning about the basic food groups, and he returns home to review his notes and get some healthy food.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Nagelatene Gedenkschriften Eener Kloosterlinge: Na Haar Overlijden Gevonden In Hare Bid-cel J. Hagen

The KAM Theory was developed in the 1960s but only in the last decade has it been applied to Earth orbiting satellites. Physical state variables of position and velocity are transformed into KAM Torus variables. The KAM Torus is a geometrical structure similar to that of a multi-dimensional donut. The Earth satellite's motion can be described as traversing the surface of this donut. There are two primary advantages of this transformation: (1) The new generalized coordinates which are analogous with mean anomaly, right ascension of the ascending node, and argument of perigee, increment linearly with time, and (2) Perturbations due to the Earth's geopotential are already embedded in a given torus to an arbitrary geopotential order. This study examines methods to describe perturbed satellite motion near a reference KAM Torus.

In recent years, the economic policy of privatisation, which is defined as the transfer of property or responsibility from public sector to private sector, is one of the global phenomenon that increases use of markets to allocate resources. One important motivation for privatisation is to help develop factor and product markets, as well as security markets. Progress in privatisation is correlated with improvements in perceived political and investment risk. Many emerging countries have gradually reduced their political risks during the course of sustained privatisation. In fact, most risk resolution seems to take place as privatisation proceeds to its later stage. Alternative benefits of privatisation are improved risk sharing and increased liquidity and activity of the market. One of the main methods to develop privatisation is entering a new stock to the markets for arising competition. This book provides leading edge research on this field from around the globe.