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This volume is the third in the series devoted to Antibiotics
initiated by Springer Verlag in 1967. The first two volumes were
devoted to the Mode of Action of Antibiotics and Biogenesis,
respectively and were received graciously. During the intervening
years these two works have been used often by research workers and
students alike and have been quoted extensively. Although a number
of other excellent treatises on antibiotics have appeared, the
Springer series has set a standard for thoroughness and quality
that meets the need of the scientific community. It is against this
background that the present Editors set about the preparation of a
third volume in the Series on Antibiotics. Since the appearance of
Volume I, also dealing with Mechanism of Action, tremendous strides
have been made in the depth and breadth of our knowledge of
molecular biology, microbial chemistry and molecular pharmacology
and of their direct application to studies on the mode of action of
drugs. The field of molecular biology itself was in its relative
infancy during the preceding decade and the unique role played by
many anti biotics in the development of our understanding of
nucleic acid synthesis and function and its relationship to protein
synthesis and cell physiology has led rapidly to a very precise,
understanding of how many of these same antibiotics inhibit
susceptible cells."
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