Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs.
The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.

Technology Applications in School Psychology Consultation, Supervision, and Training explores the ways in which the field of school psychology is using technological innovations to support and improve graduate student training and supervision, as well as school consultation. Chapters based on current research and written by experts address the integration of telehealth tools and strategies such as telepresence robots, bug-in-the-ear devices, videoconferencing, virtual platforms, and more, including a section dedicated to navigating practical, ethical, and legal concerns. Throughout, the volume engages with relevant considerations relating to data management, professional standards, and regulatory guidelines. This is a comprehensive and up-to-date resource for all those looking to understand the place and potential of established and emerging technologies within school psychology training and practice.

The region of Alsace, located between the hereditary enemies of France and Germany, served as a trophy of war four times between 1870-1945. With each shift, French and German officials sought to win the allegiance of the local populace. In response to these pressures, Alsatians invoked regionalism-articulated as a political language, a cultural vision, and a community of identity-not only to define and defend their own interests against the nationalist claims of France and Germany, but also to push for social change, defend religious rights, and promote the status of the region within the larger national community. Alsatian regionalism however, was neither unitary nor unifying, as Alsatians themselves were divided politically, socially, and culturally. The author shows that the Janus-faced character of Alsatian regionalism points to the ambiguous role of regional identity in both fostering and inhibiting loyalty to the nation. Finally, the author uses the case of Alsace to explore the traditional designations of French civic nationalism versus German ethnic nationalism and argues for the strong similarities between the two countries' conceptions of nationhood.

..".a fascinating and penetrating study .Fischer presents a nuanced analysis of Alsatian responses and shows how they were frequently contested, discontinuous, and even contradictory. General readers as well as scholars of France and Germany and those interested in problems of regionalism, nationalism, identity, memory, and cultural formation will find Alsace for the Alsatians? immensely beneficial and a pleasure to read." . Vernon L. Lidtke, Johns Hopkins University

" A] wonderfully broad and at the same time an impressive in-depth study...Fischer blends cultural and political history in exemplary ways. The strong interlinkages between regionalism and Catholicism in Alsace is powerfully highlighted by Fischer's narrative." . Stefan Berger, Professor of Modern German and Comparative European History, University of Manchester

The region of Alsace, located between the hereditary enemies of France and Germany, served as a trophy of war four times between 1870-1945. With each shift, French and German officials sought to win the allegiance of the local populace. In response to these pressures, Alsatians invoked regionalism-articulated as a political language, a cultural vision, and a community of identity-not only to define and defend their own interests against the nationalist claims of France and Germany, but also to push for social change, defend religious rights, and promote the status of the region within the larger national community. Alsatian regionalism however, was neither unitary nor unifying, as Alsatians themselves were divided politically, socially, and culturally. The author shows that the Janus-faced character of Alsatian regionalism points to the ambiguous role of regional identity in both fostering and inhibiting loyalty to the nation. Finally, the author uses the case of Alsace to explore the traditional designations of French civic nationalism versus German ethnic nationalism and argues for the strong similarities between the two countries' conceptions of nationhood.

Christopher J. Fischer received both his Masters and Doctorate degrees from the University of North Carolina at Chapel Hill. He currently is an Assistant Professor at Indiana State University.

Recipient of the Fritz Stern Prize awarded by the German Historical Institute and the Friends of the German Historical Institute."

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Halal" Arabic, literally "permissible" or "lawful." Johan Fischer's illuminating studyproves that in the modern world, halal is no longer an expression of esoteric forms of production, trade, and consumption, but part of a huge and expanding globalized market. Exploring contemporary forms of halal understanding and practice among Malay Muslims in London - that is, halal consumption by middle-class Malays on "the frontier" - evokes important and pressing questions onboth Islamic thought and how we live our lives today. "The Halal Frontier" gives us fresh insight into the religious dimensions of food consumption in an era of globalized mass production.

"

Halal" Arabic, literally "permissible" or "lawful." Johan Fischer's illuminating studyproves that in the modern world, halal is no longer an expression of esoteric forms of production, trade, and consumption, but part of a huge and expanding globalized market. Exploring contemporary forms of halal understanding and practice among Malay Muslims in London - that is, halal consumption by middle-class Malays on "the frontier" - evokes important and pressing questions onboth Islamic thought and how we live our lives today. "The Halal Frontier" gives us fresh insight into the religious dimensions of food consumption in an era of globalized mass production.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

Technology Applications in School Psychology Consultation, Supervision, and Training explores the ways in which the field of school psychology is using technological innovations to support and improve graduate student training and supervision, as well as school consultation. Chapters based on current research and written by experts address the integration of telehealth tools and strategies such as telepresence robots, bug-in-the-ear devices, videoconferencing, virtual platforms, and more, including a section dedicated to navigating practical, ethical, and legal concerns. Throughout, the volume engages with relevant considerations relating to data management, professional standards, and regulatory guidelines. This is a comprehensive and up-to-date resource for all those looking to understand the place and potential of established and emerging technologies within school psychology training and practice.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

The School of Journalism at Columbia University has awarded the Pulitzer Prize since 1917. Nowadays there are prizes in 21 categories from the fields of journalism, literature and music. The Pulitzer Prize Archive presentsthe history of this award from its beginnings to the present: In parts A toE the awarding oftheprize in each category is documented, commented and arranged chronologically. Part F covers the history of the prize biographically and bibliographically. Part G provides the background to thedecisions.

Among the symmetrical distributions with an infinite domain, the most popular alternative to the normal variant is the logistic distribution as well as the Laplace or the double exponential distribution, which was first introduced in 1774. Occasionally, the Cauchy distribution is also used. Surprisingly, the hyperbolic secant distribution has led a charmed life, although Manoukian and Nadeau had already stated in 1988 that "... the hyperbolic-secant distribution ... has not received sufficient attention in the published literature and may be useful for students and practitioners." During the last few years, however, several generalizations of the hyperbolic secant distribution have become popular in the context of financial return data because of its excellent fit. Nearly all of them are summarized within this Springer Brief.

The three volumes VIII/1A, B, C document the state of the art of "Laser Physics and Applications." Scientific trends and related technological aspects are considered by compiling results and conclusions from phenomenology, observation and experience. Reliable data, physical fundamentals and detailed references are presented. In the recent decades the laser beam source matured to a universal tool common to scientific research as well as to industrial use. Today a technical goal is the generation of optical power towards shorter wavelengths, shorter pulses and higher power for application in science and industry. Tailoring the optical energy in wavelength, space and time is a requirement for the investigation of laser-induced processes, i.e. excitation, non-linear amplification, storage of optical energy, etc. According to the actual trends in laser research and development, Vol. VIII/1 is split into three parts: Vol. VIII/1A with its two subvolumes 1A1 and 1A2 covers laser fundamentals, Vol. VIII/1B deals with laser systems and Vol. VIII/1C gives an overview on laser applications.

Computer-Assisted and Web-Based Innovations in Psychology, Special Education, and Health examines the rapid evolution of technology among educational, behavioral healthcare, and human services professionals from a multidisciplinary perspective. Section I of the book focuses on Technology for Monitoring, Assessment, and Evaluation, featuring chapters about behavioral, affective, and physiological monitoring, actigraphy measurement of exercise and physical activity, technological applications for individuals with learning disabilities/ADHD, and data analysis and graphing. In Section II, Technology for Intervention, the chapters address telehealth technologies for evidence-based psychotherapy, virtual reality therapy, substance use and addictions, and video modeling. The emphasis of Section III is Technology for Special Education, with chapters on computer-based instruction, alternative and augmentative communication, and assistive technologies. Finally, Section IV considers Technology for Training, Supervision, and Practice, specifically web-sourced training and supervision, legal, regulatory, and ethical issues with telehealth modalities, and emerging systems for clinical practice. Computer-Assisted and Web-Based Innovations is a primary resource for educating students, advising professionals about recommended practices, accelerating procedural innovations, and directing research.