Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946. Two grateful patients of Dr. House put forth the idea that his knowledge and innovative skills could be used to expand the understanding of hearing impairment and its treatment. Those two early patients provided the "seed money" to begin the Institute. Since that time, the growth has been phenomenal from a one-man laboratory to a multidisciplinary facility boasting over 175 scien tists, physicians, and support staff, all dedicated to the advancement of otologic research and education. Six years ago after a half-century of remarkable success with prosthetic and device research, the Institute began cultivating a new field of endeavor-cell and molecular biology. Don Nielsen, then the Institute's Executive Vice President for Research and Scientific Director, began exploring the potential for hair cell regen eration and presented his ideas to the Board of Trustees. For a period of six months, we did a lot of fact finding to assess what role the Institute might take in this excit ing new field."

Current, relevant, and evidence-based, The Interventional Cardiac Catheterization Handbook, 5th Edition, offers clear guidance on interventional cardiology in an easy-to-understand, concise format. This must-have handbook is an invaluable resource for physicians, nurses, and technicians in every cath lab, offering quick access to easily accessible guidelines on procedures and patient care. Packed with useful information, hundreds of clear images, and narrated videos from Dr. Kern, this practical manual ensures that health care workers at all levels have the tools they need to understand and perform these complex procedures. Covers a wide range of coronary and peripheral vascular interventional procedures, from the most common to the latest specialized interventions. Incorporates the most up-to-date equipment with detailed, step-by-step techniques, cautionary notes, and outcomes. Includes recent procedures such as TAVR, MitraClipT, atherectomy, applications of new non-hyperemic pressure ratios, and approach to LV mechanical support. Features an easy-to-read outline format, bulleted summary boxes, and quick-reference tables, making this complex subject accessible and understandable. Employs a multidisciplinary heart team approach, offering practical and authoritative guidance on the many nuances to these challenging procedures. Includes dedicated chapters on catheters, guide wires, balloons, and stents; interventional pharmacology; PCI; and complications. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Unique in comparative scope, this volume brings together global scholarship on gender. Thirteen international experts explore the gendered mobilization of men and women in twentieth century European and Asian mass dictatorships and colonial empires, examining both mobilization 'from above' and self-empowerment 'from below'.

For portable, quick access to information needed at the point of care in today's cath lab, look no farther than Kern's Cardiac Catheterization Handbook, 7th Edition. This detailed, authoritative guide is ideal for cardiologists who need a quick clinical primer on cardiac catheterization, as well as for all members of the cardiac cath team. Highly readable and accessible, it helps you provide optimal patient care with reliable information on the latest diagnostic and treatment advances in this fast-paced field. Access to this product, which may be at the discretion of your institution, is up to 3 years of online and perpetual offline access. Elsevier reserves the right to restrict or remove access due to changes in product portfolio or other market conditions. Provides clear instructions on what to expect, what to avoid, and how to manage complications for every procedure you'll encounter - including coverage of new techniques and technologies that affect virtually all aspects of familiar procedures. Covers all the newest catheterization techniques for vascular closure and expansion of large-bore access procedures, including TAVR, ECMO, mitraclip, and TMVR. Features a new chapter on intracardiac echocardiography and intraprocedural imaging. Discusses key topics such as intra-procedural imaging, management of complications with algorithms that expedite the approach to these patients, adjunctive hemodynamic support, and maintaining quality in the laboratory. Incorporates an increased emphasis on indications and contraindications for procedures in the context of a multidisciplinary heart team approach. Includes numerous clear illustrations to enhance your understanding of the material, as well as videos of Dr. Kern demonstrating various procedures in the cath lab. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946. Two grateful patients of Dr. House put forth the idea that his knowledge and innovative skills could be used to expand the understanding of hearing impairment and its treatment. Those two early patients provided the "seed money" to begin the Institute. Since that time, the growth has been phenomenal from a one-man laboratory to a multidisciplinary facility boasting over 175 scien tists, physicians, and support staff, all dedicated to the advancement of otologic research and education. Six years ago after a half-century of remarkable success with prosthetic and device research, the Institute began cultivating a new field of endeavor-cell and molecular biology. Don Nielsen, then the Institute's Executive Vice President for Research and Scientific Director, began exploring the potential for hair cell regen eration and presented his ideas to the Board of Trustees. For a period of six months, we did a lot of fact finding to assess what role the Institute might take in this excit ing new field.

Unique in comparative scope, this volume brings together global scholarship on gender. Thirteen international experts explore the gendered mobilization of men and women in twentieth century European and Asian mass dictatorships and colonial empires, examining both mobilization 'from above' and self-empowerment 'from below'.

Cardiac catheterization is a significant part of the practice of cardiology. Physicians who don't perform catheterization do refer patients for these procedures, and need to know what catheterization can accomplish in terms of diagnosis and treatment. This issue provides an excellent picture of what can be learned in the catheterization laboratory about blood flow in the heart and coronary vessels.

For this issue, Dr. Michael Lim of Johns Hopkins and Dr. Isaac Yang of UCSF team up to deliver a packed issue on the latest developments in Immunotherapy.? The issue covers hot topics such as immunostimulants, Passive Antibody Mediated Immunotherapy, Clinical Applications of A Peptide Based Vaccine, Challenges for Clinical Design of Immunotherapy Trials, The EGFRv3 Peptide Vaccine, Stem Cell Therapy and Dendritic Cell Vaccines, Dendritic Glioma Fusion Vaccine, Adoptive Cellular Immunotherapy, Virus Mediated Immunotherapy, and so much more.

An easy-to-follow map for successfully navigating the perils of personal financial planning

When it comes to their own finances, most people dont know what to do--or what not to do--until its too late. Money Mistakes You Cant Afford to Make is an easy-to-follow rule book for recognizing and avoiding the ordinary, often-overlooked financial missteps that can ruin the best-laid financial plans, and haunt investors for years.

Written by popular U.S. News & World Report editor and columnist Paul Lim, this book covers the most common money management traps. From mortgaging your 401(k) to not getting life insurance, it shows readers how to sidestep blunders, or even turn them into positives, by:

• Planning for specific life events and future needs
  
• Implementing necessary strategies for spending
  
• Determining when to follow fads or stay the course
  

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Optimization in Medicine and Biology provides researchers with a comprehensive, single-source reference that will enable them to apply the very latest optimization techniques to their work. With contributions from pioneering international experts this volume integrates strong foundational theory, good modeling techniques, and efficient and robust algorithms with relevant applications Divided into two sections, the first begins with mathematical programming techniques for medical decision making processes and demonstrates their application to optimizing pediatric vaccine formularies, kidney paired donation, and the cost-effectiveness of HIV programs. It also presents recent advances in cancer treatment planning models and solution algorithms, including three-dimensional conventional conformal radiation therapy (3DCRT), intensity modulated radiation therapy (IMRT), tomotherapy, and proton therapy. Part two focuses on optimization in biology and discusses computational algorithms for genomic analysis; probe design and selection, properties of probes, and various algorithms and software packages to aid in probe selection and design. Subsequent chapters introduce a new dihedral angle measure for protein secondary prediction, and an optimization approach for tumor virotherapy with recombinant measles viruses. The editors include a short tutorial appendix on Integer Programming (IP). Highlighting the most recent advances in optimization techniques for solving complex problems in medical research, this book facilitates strong collaborative environments among optimization researchers and medical professionals for future medical research.