Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

This completely new and updated issue takes a focused look at addiction psychiatry in three sections: Diagnostics, Therapeutics, and New Directions. Dr. Danovitch, from Cedars-Sinai and Dr. Mariani from Columbia hone in on the most rapidly advancing and relevant areas of addiction for practitioners today, from defining addiction (implications of DSM-V), to genetics and neurobiology, to specific treatment options for a variety of patient populations: for pregnant women, adolescents, and patients suffering from chronic pain, for example.? A variety of addiction types are discussed (ie, opioid, stimulant, and cannabis).? The issue closes with discussions of emerging trends, systems of care, investigational therapeutics and the role of the criminal justice system.

Now updated -- your guide to becoming an expert grill master

Are you gearing up to grill? This hands-on guide explains how to purchase, use, and maintain everything from charcoal and gas grills to smokers and rotisseries for your grill. You get the latest on the different types of grills and food prep and grilling techniques, as well as dozens of new and improved recipes that will stretch your skills and tantalize your taste buds

Get ready to grill -- understand grilling lingo, choose the right grill for you, and start and safely maintain a grill-ready fire

Add spice to your life -- stock your griller's pantry with the latest herbs, rubs, flavored oils and marinades, including Asian and Mediterranean seasonings

Grilling the oldies but goodies -- from burgers and sausages to kebabs and ribs, make everyone's favorites taste fabulous

Go beyond the BBQ basics -- expand your grilling skills with tasty tips for grilling pork, beef, poultry, lamb, fish and shellfish, vegetables, pizza, and more

Open the book and find:

The difference between regular grilling and barbecuing

Full-color photos of mouthwatering recipes

Highlights of the latest and best grilling equipment

Extended coverage on grill set-up and maintenance

Expert advice on direct and indirect grilling

Figures and charts featuring meat cuts and food prep techniques

Must-know tips and tricks to master control over the grill

Advice on using smokers and rotisseries