Seventeen-year old Dennis O'Neill was a precocious talent. Widnes coach Joe Egan put him straight into the first team after he had signed as a professional in the summer of 1966. Not only Egan, but other Rugby League pundits of the day regarded him as "the best teenage prospect since Alex Murphy" In only his second season at the age of 19, he was selected for the Lancashire side to play Yorkshire in January 1968.The game was appropriately played at Naughton Park, Widnes. O'Neill's sensational match winning try was described nearly four decades later as "The Greatest Try" by a local journalist. The description inspired the title of Anthony J. Quinn's book. Not only with a brisk season by season narrative, but with numerous references to contemporary press reports, the book vividly portrays Dennis O'Neill's thrilling performances for Widnes in the late 1960s and early 1970s. It also highlights his constant injury problems and gives the reader an insight into events at Widnes RLFC during that period in its history and is interspersed with pictures and press cuttings. In addition, the author refers to several letters and articles that were published in the local press, commenting on the poor state of British Rugby League in O'Neill's prime playing days.

This monograph presents an intuitive theory of trial wave functions for strongly interacting fermions in fractional quantum Hall states. The correlation functions for the proposed fermion interactions follow a novel algebraic approach that harnesses the classical theory of invariants and semi-invariants of binary forms. This approach can be viewed as a fitting and far-reaching generalization of Laughlin's approach to trial wave functions. Aesthetically viewed, it illustrates an attractive symbiosis between the theory of invariants and the theory of correlations. Early research into numerical diagonalization computations for small numbers of electrons shows strong agreement with the constructed trial wave functions.The monograph offers researchers and students of condensed matter physics an accessible discussion of this interesting area of research.

Many scholars of sub-Saharan Africa agree that inward-oriented development policies have hampered economic development in the region. Quinn questions traditional explanations for the low economic growth levels of sub-Saharan African countries by showing that majority state ownership of enterprise is a sufficient condition for inward-oriented policies and that this variable is a better predictor of such policies than other current explanations in the development literature. Supporting his observations through compelling case studies, Quinn offers a major statement that will be of interest to anyone concerned about African political and economic conditions and the future welfare of African peoples struggling to come to terms with the imperatives of a changing global economy.

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections: the first dealing with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate the Toll-like receptor TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of "non-self" T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer's disease, Parkinson's disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.

Ethics and Empowerment is a major contribution to the ongoing debate about the role of business in society. People expect more meaning and empowerment at work at a time when competitive pressures are seducing business into taking ethical short-cuts. How is this to be reconciled? Through a thorough examination of the issues of power, control and autonomy addressing such questions as empowerment being a matter of justice, through case-study based examinations of the organisational experiences of empowerment programmes and through looking at the ethics and empowerment debate from the wider perspective of business and social responsibility, this book seeks to make ethics more relevant and accessible to today's business world.

The subject for a volume on the fat-soluble vitamins needs no justification considering the importance of this group of nutrients and the rate of expan sion of our knowledge of its role in cell biology, genetics, and disease. The level of our understanding has clearly moved from knowing what fat soluble vitamins do to how they perform their functions. Hand in hand with a knowledge of their molecular mechanisms of action is the recognition that vitamins are used sparingly, and regeneration processes operate in certain cases to recycle vitamins from their metabolites. We have divided the volume into alphabetical sections beginning with vitamin A and the carotenoids through vitamins D, E, F, and K, and ending with coenzyme Q. The contributors are all acknowledged experts in their particular fields and have made significant contributions to published research results. All have worked assiduously to deliver the product of their labors on a restricted time scale and to provide the most up-to date information on their respective topics. We are truly grateful for their indulgence."

The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

In this timely analysis, Matthew J. Quinn plots a landmark reimagination of governance and public administration, underpinned by sustainable development and civic republicanism. He draws on governance literature and Foucault’s concept of governmentality to demonstrate the anachronism of existing bureaucratic norms and how these have thwarted sustainability and fuelled right-wing populism. Using international examples and the author’s own extensive experience in sustainability governance as a senior UK official, the book proposes a new civic bureaucracy which fosters societal engagement and dialogue. It sheds new light on debates about the emerging crisis of governance, the role of public bureaucracy and the means to embed sustainability in governance.

The Civil War Soldier and the Press examines how the press powerfully shaped the nation's understanding and memory of the common soldier, setting the stage for today's continuing debates about the Civil War and its legacy. The history of the Civil War is typically one of military strategy, famous generals, and bloody battles, but to Americans of the era, the most important story of the war was the fate of the soldier. In this edited collection, new research in journalism history and archival images provide an interdisciplinary study of citizenship, representation, race and ethnicity, gender, disability, death, and national identity. Together, these chapters follow the story of Civil War soldiers, from enlistment through battle and beyond, as they were represented in hometown and national newspapers of the time. In discussing the same pages that were read by soldiers' families, friends, and loved ones during America's greatest conflict, the book provides a window into the experience of historical readers as they grappled with the meaning and cost of patriotism and shared sacrifice. Both scholarly and approachable, this book is an enriching resource for undergraduate and graduate courses in Civil War history, American History, journalism, and mass communication history.

The Civil War Soldier and the Press examines how the press powerfully shaped the nation's understanding and memory of the common soldier, setting the stage for today's continuing debates about the Civil War and its legacy. The history of the Civil War is typically one of military strategy, famous generals, and bloody battles, but to Americans of the era, the most important story of the war was the fate of the soldier. In this edited collection, new research in journalism history and archival images provide an interdisciplinary study of citizenship, representation, race and ethnicity, gender, disability, death, and national identity. Together, these chapters follow the story of Civil War soldiers, from enlistment through battle and beyond, as they were represented in hometown and national newspapers of the time. In discussing the same pages that were read by soldiers' families, friends, and loved ones during America's greatest conflict, the book provides a window into the experience of historical readers as they grappled with the meaning and cost of patriotism and shared sacrifice. Both scholarly and approachable, this book is an enriching resource for undergraduate and graduate courses in Civil War history, American History, journalism, and mass communication history.

These new essays tell the stories of daring reporters, male and female, sent out by their publishers not to capture the news but to make the news-indeed to achieve star billing-and to capitalize on the Gilded Age public's craze for real-life adventures into the exotic and unknown. They examine the adventure journalism genre through the work of iconic writers such as Mark Twain and Nellie Bly, as well as lesser-known journalistic masters such as Thomas Knox and Eliza Scidmore, who took to the rivers and oceans, mineshafts and mountains, rails and trails of the late nineteenth century, shaping Americans' perceptions of the world and of themselves.

Basic Insights in Vector Calculus provides an introduction to three famous theorems of vector calculus, Green's theorem, Stokes' theorem and the divergence theorem (also known as Gauss's theorem). Material is presented so that results emerge in a natural way. As in classical physics, we begin with descriptions of flows.The book will be helpful for undergraduates in Science, Technology, Engineering and Mathematics, in programs that require vector calculus. At the same time, it also provides some of the mathematical background essential for more advanced contexts which include, for instance, the physics and engineering of continuous media and fields, axiomatically rigorous vector analysis, and the mathematical theory of differential forms.There is a Supplement on mathematical understanding. The approach invites one to advert to one's own experience in mathematics and, that way, identify elements of understanding that emerge in all levels of learning and teaching.Prerequisites are competence in single-variable calculus. Some familiarity with partial derivatives and the multi-variable chain rule would be helpful. But for the convenience of the reader we review essentials of single- and multi-variable calculus needed for the three main theorems of vector calculus.Carefully developed Problems and Exercises are included, for many of which guidance or hints are provided.

The book is the first thorough overview of the first important steps to develop a worldwide virtual observatory so that, in the future, it could be easier to "dial-up" a part of the sky than wait many months to access a telescope. The articles in this book present details on the status of the first efforts to develop a standardized framework for the virtual observatory, including steps towards completion and deployment of technical infrastructure, uptake by data providers worldwide, and utilization by the scientific community.

Switched capacitor (SC) techniques are well proven to be excellent candidates for implementing critical analogue functions with high accuracy, surpassing other analogue techniques when embedded in mixed-signal CMOS VLSI. Conventional SC circuits are primarily limited in accuracy by a) capacitor matching and b) the accuracy with which a differential amplifier can squeeze charge from one capacitor to another between clock periods.In Switched-Capacitor Techniques for High-Accuracy Filter and ADC Design, alternative SC techniques are proposed which allow the achievement of higher intrinsic analogue functional accuracy than previously possible in such application areas as analogue filter and ADC design...

In modern physics, various fundamental problems have become topics of ongoing debate. There was the 20th century climb to a Standard Model, still accurate at the highest energy levels obtainable so far. But, since the 1970's, a different approach to physics advocates for theories such as string theory, known for their mathematical elegance, even though they either cannot be verified in data or contradict presently known experimental results. In philosophy of physics, there is a gradually emerging consensus that philosophy of physics and physics somehow contribute to a common enterprise. But, there is little sign of progress toward consensus about the nature of that unity. All the while, it is generally recognized that physics is interdisciplinary. There are, of course, differences in focus. But, implicitly at least, there are no 'sharp dividing lines' between physics and philosophy of physics; pure and applied physics; physical chemistry; biophysics; medical physics; history and philosophy of physics; physics and society; physics education; and so on. What, then, is progress in physics? The question here is not about ideal structures, but asks about what is going on in physics. Beginnings in discerning the presence of eight main tasks help reveal the (pre-) emergence of a normative omni-disciplinary basis for collaboration that, once adverted to, promises to be constitutive of a new and increasingly effective control of meaning. Originally discovered by Bernard Lonergan in 1965, progress in the new collaboration will not seek to eliminate specialized expertise. It will, though, divide tasks within an eightfold functional division of labor. This book invites attention to data for each of the eight main tasks evident and self-evident in existing scholarship in the community. The book also makes preliminary efforts toward envisioning something of what functional collaboration will look like - in physics, the Academy and Society.

Bernard Lonergan identified the need and possibility of what he called 'generalized empirical method' in science and philosophy. Implementation will be a future community achievement. The book enters into details of a selection of examples in the sciences and philosophy of science. These are provided not to engage in, or blend the present aim with traditional philosophical debate, but as points of entry to help reveal the possibility and need of balanced empirical method. Taking words of Lonergan: '(Q)uestions of method are practical. So my purpose in these (chapters) is not to demonstrate what is necessary. It is not to forecast what is probable. It is ... to invite you to share in the exploration of a proposal' (Bernard Lonergan, A Third Collection (1985), 114). The main examples are drawn from biochemistry and biology, although heuristics envisioned will include all sciences.

In this timely analysis, Matthew J. Quinn plots a landmark reimagination of governance and public administration, underpinned by sustainable development and civic republicanism. He draws on governance literature and Foucault's concept of governmentality to demonstrate the anachronism of existing bureaucratic norms and how these have thwarted sustainability and fuelled right-wing populism. Using international examples and the author's own extensive experience in sustainability governance as a senior UK official, the book proposes a new civic bureaucracy which fosters societal engagement and dialogue. It sheds new light on debates about the emerging crisis of governance, the role of public bureaucracy and the means to embed sustainability in governance.

Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International experts cover the research that led to its emergence as an exciting, new dietary supplement.

The present volume summarizes the latest developments in various areas of CoQ research. New concepts on extramitochondrial functions of CoQ are discussed in two chapters, while recent discoveries in biosynthetic pathways for CoQ based on molecular genetic approaches are presented in another chapter.

Further chapters explore the role of CoQ as an antioxidant, revealing the need for additional research in this exciting area.

This book will be of extreme interest to biochemists, biophysicists, molecular and cell biologists, as well as nutritionists and biomedical health workers.

This monograph presents an intuitive theory of trial wave functions for strongly interacting fermions in fractional quantum Hall states. The correlation functions for the proposed fermion interactions follow a novel algebraic approach that harnesses the classical theory of invariants and semi-invariants of binary forms. This approach can be viewed as a fitting and far-reaching generalization of Laughlin's approach to trial wave functions. Aesthetically viewed, it illustrates an attractive symbiosis between the theory of invariants and the theory of correlations. Early research into numerical diagonalization computations for small numbers of electrons shows strong agreement with the constructed trial wave functions.The monograph offers researchers and students of condensed matter physics an accessible discussion of this interesting area of research.

The book is the first thorough overview of the first important steps to develop a worldwide virtual observatory so that, in the future, it could be easier to "dial-up" a part of the sky than wait many months to access a telescope. The articles in this book present details on the status of the first efforts to develop a standardized framework for the virtual observatory, including steps towards completion and deployment of technical infrastructure, uptake by data providers worldwide, and utilization by the scientific community.

The subject for a volume on the fat-soluble vitamins needs no justification considering the importance of this group of nutrients and the rate of expan sion of our knowledge of its role in cell biology, genetics, and disease. The level of our understanding has clearly moved from knowing what fat soluble vitamins do to how they perform their functions. Hand in hand with a knowledge of their molecular mechanisms of action is the recognition that vitamins are used sparingly, and regeneration processes operate in certain cases to recycle vitamins from their metabolites. We have divided the volume into alphabetical sections beginning with vitamin A and the carotenoids through vitamins D, E, F, and K, and ending with coenzyme Q. The contributors are all acknowledged experts in their particular fields and have made significant contributions to published research results. All have worked assiduously to deliver the product of their labors on a restricted time scale and to provide the most up-to date information on their respective topics. We are truly grateful for their indulgence."