Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on-off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on-off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Blurb for Volume 2
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant class proteins, and provide a comprehensive collection of proven experimental techniques for studying it both in vitro and in vivo. This second volume focuses on cutting-edge experimental techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding protein in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells. The first companion volume, Reviews and Case Histories sets the stage for this volume by introducing the various classes of intra- and extra-cellular calcium-binding proteins and their mode of action.
Single Blurb for Both Volumes
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. The first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in dairy proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins andtheir modes of action. The second volume focuses on cutting-edge experimental techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding protein in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.

Blurb for Volume 1
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. This first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in diary proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second companion volume focuses on cutting-edge experimental methods for studying solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding proteins in general.
Single Blurb for Both Volumes:
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. The first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in dairy proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second volume focuses on cutting-edge experimental techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding protein in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.

This book is not about one glorious triumph after another, nor is it a series of complaints about doctors and hospitals. Rather, these essays examine American medicine within its context, sensitive to the role of medical knowledge, practitioners, and institutions in the nineteenth and twentieth centuries. The selections not only cover general considerations of the social and cultural context in which American medicine developed but also analyze the relationship between science and medicine, the development of mental hospitals, nursing, and health insurance.

The purpose of this book, says the author, is to show the effect of Indian medicinal practices on white civilization. Actually it achieves far more. It discusses Indian theories of disease and methods of combating disease and even goes into the question of which diseases were indigenous and which were brought to the Indian by the white man. It also lists Indian drugs that have won acceptance in the Pharmacopeia of the United States and the National Formulary.The influence of American Indian healing arts on the medicine and healing and pharmacology of the white man was considerable. For example, such drugs as insulin and penicillin were anticipated in rudimentary form by the aborigines. Coca leaves were used as narcotics by Peruvian Indians hundreds of years before Carl Koller first used cocaine as a local anesthetic in 1884. All together, about 170 medicines, mostly botanical, were contributed to the official compendia by Indians north of the Rio Grande, about 50 more coming from natives of the Latin-American and Caribbean regions. Impressions and attitudes of early explorers, settlers, physicians, botanists, and others regarding Indian curative practices are reported by geographical regions, with British, French, and Spanish colonies and the young United States separately treated. Indian theories of disease - sorcery, taboo violation, spirit intrusion, soul loss, unfulfilled dreams and desires, and so on -and shamanistic practices used to combat them are described. Methods of treating all kinds of injuries-from fractures to snakebite-and even surgery are included. The influence of Indian healing lore upon folk or domestic medicine, as well as on the ""Indian doctors"" and patent medicines, are discussed. For the convenience of the reader, an index of botanical names is provided, together with a wide variety of illustrations. The disproportionate attention that has been given to the superstitious and unscientific features of aboriginal medicine has tended to obscure its real contributions to American civilization.

Grosse Rechenzentren bieten Computerleistung uber Telefonnetz und Terminal. Hersteller bieten ,,Mini" -Computersysteme , die eben soviel leisten, wie vor wenigen Jahren grosse Rechenanlagen. Be triebssysteme sind vielseitiger und gleichzeitig einfacher in der Be dienung geworden. Problemorientierte Programmiersprachen und ganze Programmpakete erleichtern die Loesung fachbezogener Pro bleme in zahlreichen Gebieten. Dies alles hat dazu gefiihrt, dass die Benutzung von Computerleistung nicht mehr einigen Computerspe zialisten vorbehalten bleibt. Vielen Ingenieuren ist heute der Com puter als Hilfsmittel zur Erfullung ihrer Aufgaben ein ebenso alltag liches Werkzeug geworden, wie es fruher der Rechenschieber war. Manchem Ingenieur oder Naturwissenschaftler fehlen jedoch die notwendigen Kenntnisse und Erfahrungen fur eine computerge rechte Loesung seiner Probleme. Der Besuch eines FORTRAN-Kur ses allein bietet hierzu keine genugende Grundlage mehr. Seit 1974 bietet deshalb das Schweizer Kapitel der Association for Computing Machinery (ACM) mit einer Reihe von Kursen und Seminaren den in der Industrie tatigen Ingenieuren die Moeglichkeit, ihre Kenntnisse in Informatik zu erweitern. Das vorliegende Werk ist aus dieser Reihe entstanden. Es wendet sich gleichermassen an Studenten von Hochschulen und Ingenieurschulen und an praktizie rende Ingenieure. Es setzt eine gewisse Programmiererfahrung vor aus: die Autoren erwarten vom Leser die Kenntnis einer Program miersprache. Das Buch ist keine Enzyklopadie, eine umfassende Behandlung des Fachgebietes Informatik ist in diesem Rahmen nicht moeglich. Die Autoren haben sich zum Ziel gesetzt, dem Leser eine Auswahl von - nach ihrem Ermessen - fur den angesprochenen Leserkreis wichtigen Themen zu bieten. Ich danke den Autoren fur die ausgezeichnete Zusammenarbeit.

This is a new release of the original 1926 edition.

This is a new release of the original 1926 edition.

1926. The author explains in the preface that other nations have known or still practice this form of animal worship. But it would be difficult to quote another instance in which it takes such a prominent place in literature folklore, and art, as it does in India. Nor would it be possible to name another country where the development of this cult can be studied during a period which may be estimated at no less than three millennia. During so vast a space of time the deified serpents have haunted the imagination of the people of Hind. But even more astonishing is the endless variety of aspect under which the Nagas appear in Indian literature and art. We meet, on the one hand, with the primitive type of the reptile endowed with the magic properties which we are wont to associate with the dragon of western fable. On the other hand, the Naga frequently has the character of a water-spirit. Again, he may be able to assume any form he chooses, and commonly appears in human shape. In Brahmanical legend he may become a pious ascetic, in Buddhist lore he may even develop into a self-denying saint very often these various types appear strangely blended. In the present volume it has been my object to collect the legends relating to the Nagas which are found in the Brahmanical and Buddhist literature of India. We do not pretend that in that gigantic body of literary tradition there may not be a Naga story which has escaped our notice. The three chief repositories of serpent-lore, the Mahabharata, the Jataka Book, and the Rajatarangini, have, at least, been fully utilized. But for the rest it is questionable whether much would have been gained by aiming at completeness. The stories here presented will certainly suffice to show the Nagas in that great variety of aspect to which reference has been made.

Technology has invaded the classroom. As instructors attempt to transform their traditional teaching methods to meet the demands of the new digital age, universities across the nation are pushing to move more classes online. To meet the demands of the students for a new "media rich" learning environment, educators must explore new technologies that will increase student collaboration and engagement. This guide will look at instant messaging and how it can be used in the online learning environment and specifically how the new version of iChat has opened new avenues of exploration. This is not a book filled with theory - full of confusing jargon and detailed concepts. This is a book on what button to push, which settings to use, and when to use it within the iChat application.

1926. The author explains in the preface that other nations have known or still practice this form of animal worship. But it would be difficult to quote another instance in which it takes such a prominent place in literature folklore, and art, as it does in India. Nor would it be possible to name another country where the development of this cult can be studied during a period which may be estimated at no less than three millennia. During so vast a space of time the deified serpents have haunted the imagination of the people of Hind. But even more astonishing is the endless variety of aspect under which the Nagas appear in Indian literature and art. We meet, on the one hand, with the primitive type of the reptile endowed with the magic properties which we are wont to associate with the dragon of western fable. On the other hand, the Naga frequently has the character of a water-spirit. Again, he may be able to assume any form he chooses, and commonly appears in human shape. In Brahmanical legend he may become a pious ascetic, in Buddhist lore he may even develop into a self-denying saint very often these various types appear strangely blended. In the present volume it has been my object to collect the legends relating to the Nagas which are found in the Brahmanical and Buddhist literature of India. We do not pretend that in that gigantic body of literary tradition there may not be a Naga story which has escaped our notice. The three chief repositories of serpent-lore, the Mahabharata, the Jataka Book, and the Rajatarangini, have, at least, been fully utilized. But for the rest it is questionable whether much would have been gained by aiming at completeness. The stories here presented will certainly suffice to show the Nagas in that great variety of aspect to which reference has been made.

1926. The author explains in the preface that other nations have known or still practice this form of animal worship. But it would be difficult to quote another instance in which it takes such a prominent place in literature folklore, and art, as it does in India. Nor would it be possible to name another country where the development of this cult can be studied during a period which may be estimated at no less than three millennia. During so vast a space of time the deified serpents have haunted the imagination of the people of Hind. But even more astonishing is the endless variety of aspect under which the Nagas appear in Indian literature and art. We meet, on the one hand, with the primitive type of the reptile endowed with the magic properties which we are wont to associate with the dragon of western fable. On the other hand, the Naga frequently has the character of a water-spirit. Again, he may be able to assume any form he chooses, and commonly appears in human shape. In Brahmanical legend he may become a pious ascetic, in Buddhist lore he may even develop into a self-denying saint very often these various types appear strangely blended. In the present volume it has been my object to collect the legends relating to the Nagas which are found in the Brahmanical and Buddhist literature of India. We do not pretend that in that gigantic body of literary tradition there may not be a Naga story which has escaped our notice. The three chief repositories of serpent-lore, the Mahabharata, the Jataka Book, and the Rajatarangini, have, at least, been fully utilized. But for the rest it is questionable whether much would have been gained by aiming at completeness. The stories here presentedwill certainly suffice to show the Nagas in that great variety of aspect to which reference has been made.

1926. The author explains in the preface that other nations have known or still practice this form of animal worship. But it would be difficult to quote another instance in which it takes such a prominent place in literature folklore, and art, as it does in India. Nor would it be possible to name another country where the development of this cult can be studied during a period which may be estimated at no less than three millennia. During so vast a space of time the deified serpents have haunted the imagination of the people of Hind. But even more astonishing is the endless variety of aspect under which the Nagas appear in Indian literature and art. We meet, on the one hand, with the primitive type of the reptile endowed with the magic properties which we are wont to associate with the dragon of western fable. On the other hand, the Naga frequently has the character of a water-spirit. Again, he may be able to assume any form he chooses, and commonly appears in human shape. In Brahmanical legend he may become a pious ascetic, in Buddhist lore he may even develop into a self-denying saint very often these various types appear strangely blended. In the present volume it has been my object to collect the legends relating to the Nagas which are found in the Brahmanical and Buddhist literature of India. We do not pretend that in that gigantic body of literary tradition there may not be a Naga story which has escaped our notice. The three chief repositories of serpent-lore, the Mahabharata, the Jataka Book, and the Rajatarangini, have, at least, been fully utilized. But for the rest it is questionable whether much would have been gained by aiming at completeness. The stories here presentedwill certainly suffice to show the Nagas in that great variety of aspect to which reference has been made.