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Imaging of the Dopaminergic system in the human brain with the in
vivo use of Positron Emis- sion Tomography has emerged in the late
1980s as a tool of major importance in Clinical Neuros- ciences and
Pharmacology. The last few years have witnessed the rapid
development of new radiotracers specific to receptors, reuptake
sites and enzymes of the dopamine system; the application of these
radiotracers has led to major breakthroughs in the pathophysiology
and therapy of movement disorders and schizophrenic-like psychoses.
This book is the first to collect, in a single volume,
state-of-the-art contributions to the various aspects of this
research. Its contents address methodological issues related to the
design, labelling, quantitative imaging and compartmental
modelisation of radioligands of the post-synaptic, pre-synaptic and
enzyme sites of the dopamine system and to their use in clinical
research in the fields of Parkinson's disease as well as other
movement disorders, psychoses and neuroleptic receptor occupancy.
The chapters were written by leading European scientists in the
field of Positron Emission Tomography, gathered together in Caen
(France, November 1990) under the aegis of the EEC Concerted Action
on "PET Investigations of Cellular Regeneration and Degeneration.
This book provides a current and comprehensive overview on PET
studies of the brain dopamine system which should aid and interest
neurologists, psychiatrists, pharmacologists and medical imaging
scientists. J. C. Baron D. Comar L. Farde J. L. Martinot B. Mazoyer
August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.
1. Neuroanatomy of dopaminergic system in the human brain.- 2.
Radioligands for PET studies of D2-receptors: butyrophenone and
ergot derivatives.- 3. Radioligands for dopamine receptor PET
studies: benzamides and ligands for dopamine D-1 receptors.- 4.
Monoamine precursors in PET research - biochemical issues and
functional significance.- 5. Quantitation problems in positron
emission tomography (PET) as applied to the kinetic analysis of the
striatum dopamine data.- 6. Investigation of the dopamine system
with positron emission tomography: general issues in modeling.- 7.
Modelisation: application to the D2 receptors.- 8. [18F] Fluorodopa
uptake in brain.- 9. Dopamine reuptake sites: the issues.- 10.
Movement disorders: the clinical issues.- 11. Non-human primate
models of dopamine system disorders: understanding
neurodegenerative diseases and testing new therapeutic strategies.-
12. The dopamine system and mental disorders: clinical and
psychopharmacological overview.- 13. D2 dopamine receptors and
schizophrenia.- 14. The assessment of central D2-dopanvne receptor
occupancy with positron emission tomography in long-term medicated
schizophrenic patients.- 15. Measurement of dopamine receptor
occupancy: clinical issues.
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