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In recent years the field of contact dermatitis has increased
greatly in importance in dermatology. The variety of exogenous,
environmental ly caused dermatoses has undoubtedly expanded over
the past few de cades with the increasing number of potentially
toxic chemicals, the changes in lifestyle, and the greater life
expectancy in industrialized societies. The value of international
cooperation in this field has long been realized and acted upon by
the International Contact Dermatitis Re search Group (ICDRG). By
1975 the international journal Contact Dermatitis had been founded
under the editorship of C. D. Calnan. Thanks largely to the ICDRG
and Contact Dermatitis, there were, by 1986, enough additional
dermatologists and scientists with a special interest in this area
to form the European Environmental and Contact Dermatitis Research
Group (EECDRG). Within 2 years they had in stituted the European
Society of Contact Dermatitis (ESCD) as an in ternational forum for
researchers in the field. The EECDRG decided to hold a symposium in
Heidelberg in May 1988, an initiative supported by the ICDRG, and
on this occasion the new ESCD held its inaugural session. The
Society already has over 200 members and most national contact
dermatitis research groups in Europe are already represented; new
members are of course welcome. Subgroups and working committees
have been formed to address var ious topics including the
standardization of patch testing, photoder matology, and
bioengineering."
It is now thirty years since William Montagna and Richard Ellis
edited 'The Biology of Hair Growth". In his introduction, Stephen
Rothman, of the University of Chicago, USA and one of the driving
forces behind research on skin at the time, wrote: 'The pilary
system is a perfect micr9cosmic structure. In this microcos- mos we
find birth, development, ageing and death, activity and rest, color
for- mation and decolorification, greasiness and dryness, infection
and sterilization, hypertrophy and atrophy, Qenign tumours and
malignant ones. " He foresaw the human pilary system as a model for
the study of a multitude of human diseases including ageing and
cancer. It was not, how- ever, until the seventies that the
development of micro-biochemical tech- niques indeed allowed the
use of the human hair follicle as a convenient biopsy tissue for
Biomedical Research in general. Measurement of enzyme activities,
and important co-factors, and culturing of cells from single
follicles all became possible. In the eighties dermal papilla cells
were grown in cul- ture and this opened the way to study hair
differentiation in vitro. Studying hair differentiation is, in
fact, studying growth regulation and it is this aspect that by far
transcends the importance of studying hair growth itself. Let us
not forget that metastatic prostate cancer is treated with the same
drug -cyproterone acetate -that is used for the treatment of
alopecia and hirsutism in women.
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