This book constitutes the refereed proceedings of the 13th Colombian Conference on Computing, CCC 2018, held in Cartagena, Colombia, in September 2018. The 46 revised full papers presented were carefully reviewed and selected from 194 submissions. The papers deal with the following topics: information and knowledge management, software engineering and IT architectures, educational informatics, intelligent systems and robotics, human-computer interaction, distributed systems and large-scale architectures, image processing, computer vision and multimedia, security of the information, formal methods, computational logic, and theory of computation.