Physiologic compartmentalization effectively isolates the central nervous system from the rest of the body. This isolation not only provides protection of its delicate function from aberrant peripheral influences but also impedes its diagnostic evaluation. Cerebro spinal fluid (CSF) bathes the brain and spinal cord, is in dynamic equilibrium with its extracellular fluid, and tends to reflect the state of health and activity of the central nervous system. CSF examination is the most direct and popular method of assessing the central chemical and cellular environment in the living patient or mammal. The purpose of this multidisciplined reference text is to provide the sophisticated knowledge of CSF physiology and pathology necessary for the meaningful interpretation of data obtained by various types of CSF analysis. The methodology for reliable CSF collection, storage, preparation, and analysis is discussed with respect to individual, somatotropic, chronologic, endorcinologic, pharmacologic, and possible artifactual var iations in CSF composition. These essential aspects, which ensure the validity of CSF data, are presented to aid the investigator in clinical and experimental protocol formu lation and in elimination of possible sources of error."

Since the publication of Neurobiology of Cerebrospinal Fluid 1 in 1980, that text has become the definitive reference concerning cerebrospinal fluid (CSF) for both basic scientists and clinicians involved in the investigation of degenerative, convulsive, cerebrovascular, traumatic, immunological, demyelinating, inflammatory, neoplastic, neuroendocrine, and psychiatric disorders. That initial volume began a tradition of detailed topic reviews written by international authorities with first-hand expertise in their respective fields of CSF research. Neurobiology of Cerebrospinal Fluid 2 represents a hefty collection of extensively refer enced and illustrated chapters covering topics not discussed in Vol. 1. More specifically, these chapters contain ample charts of original data, summary charts, and anatomical diagrams. Detailed illustrations of experimental and clinical techniques have been in cluded to facilitate their practical application. Each chapter in this multidisciplinary text has been critically reviewed by two experts in the respective field, and the appropriate revisions have been made. Recently published references and text modifications have been added at the proof stage in an effort to provide the most up-to-date review chapters possible."

This comprehensive text on the pharmacological, medical, and legal aspects of drug abuse has been thoroughly updated for the Fourth Edition, and a new chapter on club drugs added. The chapter on medical effects was completely rewritten to focus on infections that develop in i.v. drug abusers, and information on the international regulation of drug use was added to the chapter on drug abuse and the law. The book is written at a level appropriate for upper level undergraduate students, graduate or medical students, and drug counselors. All major drugs of abuse are covered: tobacco, opiods, central stimulants (including cocaine, amphetamine, and caffeine), alcohol and other sedatives marijuana, club drugs (MDMA, GHB, and ketamine), hallucinogens, and volatile solvents. For each type the authors discuss history and culture, the characteristic patterns of use, subjective and physiological effects, mechanisms of pharmacological action, and toxic effects. Epidemiological aspects are discussed as well as pharmacological treatment possibilities where applicable.

This comprehensive text on the pharmacological, medical, and legal aspects of drug abuse has been thoroughly updated for the Fourth Edition, and a new chapter on club drugs added. The chapter on medical effects was completely rewritten to focus on infections that develop in i.v. drug abusers, and information on the international regulation of drug use was added to the chapter on drug abuse and the law. The book is written at a level appropriate for upper level undergraduate students, graduate or medical students, and drug counselors. All major drugs of abuse are covered: tobacco, opioids, central stimulants (including cocaine, amphetamine, and caffeine), alcohol and other sedatives, marijuana, club drugs (MDMA, GHB, and ketamine), hallucinogens, and volatile solvents. For each type the authors discuss history and culture, the characteristic patterns of use, subjective and physiological effects, mechanisms of pharmacological action, and toxic effects. Epidemiological aspects are discussed as well as pharmacological treatment possibilities where applicable.

These brief memoirs of the War between the States have been written with care. More elaborate detail might have been employed but habits of a professional life have led to terseness of expression, hence the story unembellished is given, based on personal recollections aided by facts from others and such records as I have been able to reach, including Strickler's Statistics of dates of battles. No effort has been made to do more than to give a brief account of the events seen and known directly or from sources above mentioned. This was undertaken for the purpose of leaving to comrades who still live, to the families of those who are dead, to our own families and to posterity some record, from our view-point, of the most stirring events and enactments of our lives. To the extent of my rank I was a participant in the scenes described - except two battles - from which disability from wounds prevented. "The Regiment" creditably participated in all.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.