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A wide range of microbiologists, molecular biologists, and
molecular evolutionary biologists will find this new volume of
singular interest. It summarizes the present knowledge about the
structure and stability of microbial genomes, and reviews the
techniques used to analyze and fingerprint them. Maps of
approximately thirty important microbes, along with articles on the
construction and relevant features of the maps are included. The
volume is not intended as a complete compendium of all information
on microbial genomes, but rather focuses on approaches, methods and
good examples of the analysis of small genomes.
A grand summary and synthesis of the tremendous amount of data now
available in the post genomic era on the structural features,
architecture, and evolution of the human genome. The authors
demonstrate how such architectural features may be important to
both evolution and to explaining the susceptibility to those DNA
rearrangements associated with disease. Technologies to assay for
such structural variation of the human genome and to model genomic
disorders in mice are also presented. Two appendices detail the
genomic disorders, providing genomic features at the locus
undergoing rearrangement, their clinical features, and frequency of
detection.
Bacterial Genomes provides an in-depth review of the latest
research on the structure and stability of microbial genomes, and
the techniques used to analyze and "fingerprint" them. Maps of a
variety of microorganisms are featured, along with articles
describing their construction and relevant features. Extensive
tables summarizing the different types of techniques available to
analyze the genomes of these microorganisms are also presented.
Among those who will find this text most useful are genome
researchers, microbiologists, molecular biologists,
bacteriologists, infectious disease researchers, and molecular
evolutionary biologists. Researchers and students working in the
field of molecular evolution in general will also be interested in
this book since microbes are such popular model systems.
Genomics of Rare Diseases: Understanding Disease Genetics Using
Genomic Approaches, a new volume in the Translational and Applied
Genomics series, offers readers a broad understanding of current
knowledge on rare diseases through a genomics lens. This clear
understanding of the latest molecular and genomic technologies used
to elucidate the molecular causes of more than 5,000 genetic
disorders brings readers closer to unraveling many more that remain
undefined and undiscovered. The challenges associated with
performing rare disease research are also discussed, as well as the
opportunities that the study of these disorders provides for
improving our understanding of disease architecture and
pathophysiology. Leading chapter authors in the field discuss
approaches such as karyotyping and genomic sequencing for the
better diagnosis and treatment of conditions including recessive
diseases, dominant and X-linked disorders, de novo mutations,
sporadic disorders and mosaicism.
A grand summary and synthesis of the tremendous amount of data now
available in the post genomic era on the structural features,
architecture, and evolution of the human genome. The authors
demonstrate how such architectural features may be important to
both evolution and to explaining the susceptibility to those DNA
rearrangements associated with disease. Technologies to assay for
such structural variation of the human genome and to model genomic
disorders in mice are also presented. Two appendices detail the
genomic disorders, providing genomic features at the locus
undergoing rearrangement, their clinical features, and frequency of
detection.
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