A grand summary and synthesis of the tremendous amount of data now
available in the post genomic era on the structural features,
architecture, and evolution of the human genome. The authors
demonstrate how such architectural features may be important to
both evolution and to explaining the susceptibility to those DNA
rearrangements associated with disease. Technologies to assay for
such structural variation of the human genome and to model genomic
disorders in mice are also presented. Two appendices detail the
genomic disorders, providing genomic features at the locus
undergoing rearrangement, their clinical features, and frequency of
detection.
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