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Fungi occupy an important place in the natural world, as
non-photosynthetic organisms, they obtain their nutrients from the
degradation of organic material. They use many of their secondary
metabolites to secure a place in a competitive natural environment
and to protect themselves from predation. The diverse structures,
biosyntheses and biological activities of fungal metabolites have
attracted chemists for many years. Fungi are ubiquitous and their
activities affect many aspects of our daily lives whether it be as
sources of pharmaceuticals and food or as spoilage organisms and
the causes of diseases in plants and man. The chemistry of the
fungi involved in these activities has been the subject of
considerable study particularly over the last fifty years. Although
their ramifications can be large as in the spread of plant
diseases, the quantities of the metabolites which could be isolated
precluded much chemical work until the advent of spectroscopic
methods. Whereas many natural products derived from plants were
isolated prior to the 1960s on a scale which permitted extensive
chemical degradation, this was rarely the case for fungal
metabolites. This book is an introduction to the chemistry of
fungal metabolites. The aim is to illustrate within the context of
fungal metabolites, the historical progression from chemical to
spectroscopic methods of structure elucidation, the development in
biosynthetic studies from establishing sequences and mechanisms to
chemical enzymology and genetics and the increasing understanding
of the biological roles of natural products. The book begins with a
historical introduction followed by a description of the general
chemical features which contribute to the growth of fungi. There
are many thousands of fungal metabolites whose structures are known
and the book does not aim to list them all as there are databases
to fulfill this role. The book's aim is to describe some of the
more important metabolites classified according to their
biosynthetic origin. Biosynthesis provides a unifying feature
underlying the diverse structures of fungal metabolites and the
chapters covering this area begin with a general outline of the
relevant biosynthetic pathway before presenting a detailed
description of particular metabolites. Investigations into these
biosyntheses have utilized many subtle isotopic labelling
experiments and compounds that are fungal pigments and those which
are distinctive metabolites of the more conspicuous Basidiomycetes
are treated separately. Many fungal metabolites are involved in the
interactions of fungi with plants and others are toxic to man and
some of these are described in further chapters. Fungi have the
ability to transform chemicals in ways which can complement
conventional reactions and the use of fungi as reagents forms the
subject of the final chapter. This book will be particularly useful
to anybody about to embark on a career in chemical microbiology by
providing an overall perspective of fungal metabolites as well as
an essential reference tool for more general chemists.
Natural products are compounds that are produced by living systems
and the secondary metabolites are those which give particular
species their characteristic features. These natural products
include polyketides, terpenoids, phenylpropanoids, alkaloids and
antibiotics. The study of these natural products has played a major
part in the development of organic and medicinal chemistry and we
are now starting to understand the important ecological role that
these compounds have. The aim of this book is to describe the major
features of these compounds and the way in which chemical and
physical methods have been used to establish their structures and
then to show how these structures can be rationalised in
biosynthetic terms. The first chapter describes the classes of
natural product, their biological activity and isolation.
Subsequent chapters attempt to link chemical and spectroscopic
strategies in structure elucidation, contrasting the classical
chemical strategies that were used in the past with modern
spectroscopic methods. The final chapter describes the biosynthesis
of natural products. The elucidation of the structures of natural
products brings together many elements taught in courses on
functional group chemistry, stereochemistry and elementary
spectroscopy. This book will therefore be welcomed by lecturers and
students of second-year chemistry courses. Ideal for the needs of
undergraduate chemistry students, Tutorial Chemistry Texts is a
major series consisting of short, single topic or modular texts
concentrating on the fundamental areas of chemistry taught in
undergraduate science courses. Each book provides a concise account
of the basic principles underlying a given subject, embodying an
independent-learning philosophy and including worked examples.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Specialist Periodical Reports provide systematic and detailed
review coverage of progress in the major areas of chemical
research. Written by experts in their specialist fields the series
creates a unique service for the active research chemist, supplying
regular critical in-depth accounts of progress in particular areas
of chemistry. For over 90 years The Royal Society of Chemistry and
its predecessor, the Chemical Society, have been publishing reports
charting developments in chemistry, which originally took the form
of Annual Reports. However, by 1967 the whole spectrum of chemistry
could no longer be contained within one volume and the series
Specialist Periodical Reports was born. The Annual Reports
themselves still existed but were divided into two, and
subsequently three, volumes covering Inorganic, Organic and
Physical Chemistry. For more general coverage of the highlights in
chemistry they remain a 'must'. Since that time the SPR series has
altered according to the fluctuating degree of activity in various
fields of chemistry. Some titles have remained unchanged, while
others have altered their emphasis along with their titles; some
have been combined under a new name whereas others have had to be
discontinued. The current list of Specialist Periodical Reports can
be seen on the inside flap of this volume.
Medicinal chemistry incorporates bio-organic chemistry, organic
synthetic methods, physical organic chemistry and organic reaction
mechanisms. These areas of chemistry are crucial to the design and
synthesis of new drugs, both in academia and the pharmaceutical
industry. Chemistry and Medicines: An Introductory Text provides a
general introduction to this fascinating subject. The first
chapters contain a brief historical introduction followed by a
description of the chemical features involved in the adsorption,
distribution, metabolism and excretion of a drug. The remaining
chapters describe the chemistry underlying the design and synthesis
of some of the key drugs used to combat some major diseases of the
peripheral and central nervous system, infectious diseases and
cancers. A glossary and suggestions for further reading complete
this textbook. The book is aimed at those studying advanced
undergraduate and postgraduate courses in medicinal chemistry.
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Functional Group Chemistry (Paperback)
E.W. Abel; Contributions by John D. Hepworth; Series edited by A.G. Davies, David Phillips, J. Derek Woollins; …
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R702
Discovery Miles 7 020
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Ships in 10 - 15 working days
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Functional Group Chemistry presents the chemistry of functional
groups with an emphasis on patterns of reactivity, the consequences
of the relative electronegativity of the atoms that constitute
functional groups, the role of lone pairs and the stereochemistry
of reactions at a particular group. The material is presented in
four chapters. The first chapter describes some of the general
principles that affect the reactivity of functional groups. The
second chapter examines the chemistry of functional groups
involving - C-X bonds as in alkyl halides, alcohols, ethers, amines
and organometallic reagents. The third chapter covers the chemistry
of both symmetrical and unsymmetrical -bonded functional groups,
typified by alkenes and carbonyl groups. The final chapter
concentrates on aromatic compounds. It is concerned with the
interactions between an aromatic ring and functional groups that
are attached to it, such as their effect on the orientation of
aromatic substitution. Each chapter concludes with a series of
problems. The chemistry of the functional groups is considered here
with a mechanistic rationale. Students are encouraged to consider
the reactivity of functional groups in terms of their regions of
electron deficiency and excess, and hence to identify the sites at
which nucleophiles and electrophiles might react. Additional
material is available on the website at www.rsc.org/tct Ideal for
the needs of undergraduate chemistry students, Tutorial Chemistry
Texts is a major series consisting of short, single topic or
modular texts concentrating on the fundamental areas of chemistry
taught in undergraduate science courses. Each book provides a
concise account of the basic principles underlying a given subject,
embodying an independent-learning philosophy and including worked
examples.
The chemical synthesis of isotopically labelled compounds is a
pre-requisite for many chemical, biochemical and medicinal
investigations. The constraints imposed by the requirements for
regiospecific labelling and, in some instances, the time-scale of
the synthesis often lead to quite different synthetic strategies to
those that are used for the unlabelled material. Whilst there are
many specialist papers, reviews and long books devoted to
particular isotopes, there is no currently available short
introductory book devoted to the organic chemistry of isotopic
labelling. The aim of this book is to introduce research workers to
a variety of methods that have been used to achieve these synthetic
labelling objectives before exploring a particular method in
detail. It covers a number of different isotopes and the methods
that have been used to introduce them into organic compounds.
Labelling methods also provide useful undergraduate teaching
examples of modern synthetic reactions and their stereochemical
consequences using relatively simple substrates. The book will
therefore have a wider appeal than just those involved in using
isotopes in research such as environmental and pharmaceutical
chemists as well as organic chemists.
Synthesis is one of the major endeavours of the organic chemist,
and the design of a successful synthesis requires a sound knowledge
of functional group chemistry, stereochemistry and organic reaction
mechanisms. Organic Synthetic Methods introduces the major methods
of creating carbon-carbon and carbon-nitrogen bonds, along with
functional group interconversions (oxidation, reduction,
halogenation). The use of protecting groups and solid-phase methods
are also discussed. The analysis of the structure of a target
molecule, in terms of the structural consequences of synthetic
reactions, is introduced to enable the student to identify key
dissections and building blocks and hence develop a suitable
synthetic method. Examples of the synthesis of labelled compounds
are also provided. Ideal for the needs of undergraduate chemistry
students, Tutorial Chemistry Texts is a major new series consisting
of short, single topic or modular texts concentrating on the
fundamental areas of chemistry taught in undergraduate science
courses. Each book provides a concise account of the basic
principles underlying a given subject, embodying an
independent-learning philosophy and including worked examples.
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