The chemical synthesis of isotopically labelled compounds is a
pre-requisite for many chemical, biochemical and medicinal
investigations. The constraints imposed by the requirements for
regiospecific labelling and, in some instances, the time-scale of
the synthesis often lead to quite different synthetic strategies to
those that are used for the unlabelled material. Whilst there are
many specialist papers, reviews and long books devoted to
particular isotopes, there is no currently available short
introductory book devoted to the organic chemistry of isotopic
labelling. The aim of this book is to introduce research workers to
a variety of methods that have been used to achieve these synthetic
labelling objectives before exploring a particular method in
detail. It covers a number of different isotopes and the methods
that have been used to introduce them into organic compounds.
Labelling methods also provide useful undergraduate teaching
examples of modern synthetic reactions and their stereochemical
consequences using relatively simple substrates. The book will
therefore have a wider appeal than just those involved in using
isotopes in research such as environmental and pharmaceutical
chemists as well as organic chemists.
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