In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. Coverage includes protein translocation and export, lipid metabolism, antigen presentation, and many other subjects, gleaned from such diverse fields as cell biology, enzymology and membrane biochemistry, immunology, and signal transduction.

This latest volume summarizes the current state of knowledge of membrane assembly. It covers subjects germane to most membranes as well as to membranes of different organelles for prokaryote, plant, and animal cells.

1 Biochemical, Immunological, and Molecular Markers of Hemopoietic Precursor Cells.- 1. Introduction.- 2. Biochemical Markers.- 2.1. Terminal Deoxynucleotide Transferase.- 2.2. Enzymes in Nucleotide Metabolism.- 3. Immunological Markers.- 4. Molecular Markers.- 5. Analysis of Human Hemopoietic Ontogenesis by Immunological and Molecular Markers.- 6. New Opportunities for Immunological and Molecular Markers: Minimal Residual Disease Detection and Therapeutical Approaches.- 7. References.- 2 Cell Surface Markers in Leukemia and Lymphoma.- 1. Introduction.- 2. B Cells.- 2.1. Normal B-Cell Ontogeny.- 2.2. B-Cell Leukemias and Lymphomas.- 3. T Cells.- 3.1. Normal T-Cell Ontogeny.- 3.2. T-Cell Leukemias and Lymphomas.- 4. Myeloid Cells.- 4.1. Normal Myeloid Ontogeny.- 4.2. Myeloid Leukemias.- 5. Summary.- 6. References.- 3 Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts.- 1. Introduction.- 2. Microfilaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 2.1. Actin and Actin-Associated Proteins in Nonmuscle Cells.- 2.2. Actin Isoforms.- 2.3. Organization of Actin in Normal Lymphocytes.- 2.4. Interactions between Actin and Surface Antigens in Lymphocytes.- 2.5. Actin in Leukemic Lymphocytes and Lymphoblasts.- 3. Intermediate-Size Filaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 3.1. The Intermediate Filament System.- 3.2. Distribution of Vimentin in Lymphocytes in Normal Conditions.- 3.3. Vimentin in Neoplastic Lymphocytes and Lymphoblasts.- 3.4. Expression of Cytokeratin in Lymphoid Tissues.- 4. Microtubules in Lymphoid Cells.- 5. Organization of Spectrin in Lymphocytes.- 6. Conclusions.- 7. References.- 4 Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation.- 1. Introduction.- 2. B-Cell Antigen Receptor-Mediated Signaling.- 3. Molecular Bases of T-Cell-Mediated B-Cell Signaling.- 4. Biological Evidence for Ia-Mediated Signal Transduction.- 5. Biochemical Evidence for Ia-Mediated Signal Transduction.- 6. Conclusions.- 7. References.- 5 IgE Receptors on Lymphocytes and IgE-Binding Factors.- 1. Introduction.- 2. Historical Overview.- 3. Fc?RII on Lymphocytes.- 3.1. Fc?RII-Bearing Cells.- 3.2. Function of Fc?RII.- 3.3. Molecular Properties of Fc?RII.- 3.4. Regulation of Fc?RII Expression on Lymphocytes.- 4. IgE-Binding Factors.- 4.1. Rat.- 4.2. Murine.- 4.3. Human.- 5. Glycosylation-Regulating Factors: GEF and GIF.- 5.1. Rat.- 5.2. Murine.- 6. Interleukin 4 and Gamma Interferon.- 7. CD23 Antigen.- 8. Conclusion.- 9. References.- 6 Lymphocyte-Mediated Cytolysis: Role of Granule Mediators.- 1. Role of Granules and Perform in Lymphocyte-Mediated Killing.- 1.1. The Granule Exocytosis or Secretion Model for Cell Killing.- 1.2. Cytoplasmic Granules and Perform as Mediators of Cytotoxicity.- 1.3. A Family of Serine Esterases Localized in Lymphocyte Granules.- 1.4. Proteoglycans.- 1.5. Leukalexins and Cytokines Related to Tumor Necrosis Factor and Lymphotoxin.- 2. Other Candidate Mechanisms of Lymphocyte-Mediated Killing.- 3. Resistance of Lymphocytes to Self-Mediated Killing.- 4. Conclusion.- 5. References.- 7 CR1-Cytoskeleton Interactions in Neutrophils.- 1. Introduction.- 2. Detergent Extraction of Cells.- 3. Receptor-Cytoskeleton Interactions.- 4. The C3b Receptor (CR1).- 5. References.- 8 The Flow of Granular Organelles in Leukocyte Differentiation.- 1. Introduction.- 2. Biogenesis of Membrane-Bound Organelles.- 2.1. Introduction.- 2.2. Endoplasmic Reticulum.- 2.3. Golgi Complex.- 2.4. Lysosomes.- 2.5. Communication between Compartments: Endosomes.- 2.6. Secretory Granules.- 3. Leukocyte Granules are Major Determinants of Function.- 3.1. Neutrophils.- 3.2. Platelets.- 3.3. Cytotoxic Lymphocytes.- 4. Granules Interact with the Plasma Membrane.- 4.1. Neutrophils.- 4.2. Platelets.- 5. Pathology of Myeloid Granules and Plasma Membranes.- 5.1. Nonneoplastic.- 5.2. Leukemic.- 6. Conclusion.- 7. References.- 9 The Elusive Oxidase: The Respiratory Burst Oxidase of Human Phagocytes...