Respiratory motion causes an important uncertainty in radiotherapy planning of the thorax and upper abdomen. The main objective of radiation therapy is to eradicate or shrink tumor cells without damaging the surrounding tissue by delivering a high radiation dose to the tumor region and a dose as low as possible to healthy organ tissues. Meeting this demand remains a challenge especially in case of lung tumors due to breathing-induced tumor and organ motion where motion amplitudes can measure up to several centimeters. Therefore, modeling of respiratory motion has become increasingly important in radiation therapy. With 4D imaging techniques spatiotemporal image sequences can be acquired to investigate dynamic processes in the patient's body. Furthermore, image registration enables the estimation of the breathing-induced motion and the description of the temporal change in position and shape of the structures of interest by establishing the correspondence between images acquired at different phases of the breathing cycle. In radiation therapy these motion estimations are used to define accurate treatment margins, e.g. to calculate dose distributions and to develop prediction models for gated or robotic radiotherapy. In this book, the increasing role of image registration and motion estimation algorithms for the interpretation of complex 4D medical image sequences is illustrated. Different 4D CT image acquisition techniques and conceptually different motion estimation algorithms are presented. The clinical relevance is demonstrated by means of example applications which are related to the radiation therapy of thoracic and abdominal tumors. The state of the art and perspectives are shown by an insight into the current field of research. The book is addressed to biomedical engineers, medical physicists, researchers and physicians working in the fields of medical image analysis, radiology and radiation therapy.

Volume 2 provides a practice-oriented presentation of the content and scope of copyright protection for media products. It explains copyright laws applicable to different categories of works and offers suggestions for contract design.

Media law as a means of organization in the real world and the virtual world continues to gain in economic and cultural importance. The global market and the networking of information and communication processes require an improved legal framework for media law in the 21st century. It is not merely production conditions that have been impacted by the digital revolution, but the manner of marketing media products and the use of such are increasingly being conducted in the Internet. In addition to the classical fields of media law, such as press, broadcasting and film, these five volumes also take into account issues pertaining to sports, theater and electronic media. The presentation includes media law-related aspects of the law of competition, telemedia law and copyright law as well as the laws regarding broadcasting, press, personality rights, telecommunications, data protection, samples/design, and domain rights; licensing contract law, the law of publication, media criminal law, photography law as well as media cartel law are also discussed. This complete presentation of media law particularly addresses the European legal framework. Attorneys, legal scholars and media experts comprehensively and systematically address the processes in society relevant to media law in their contributions to the five volumes of this handbook.