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The existence of genes for RNA molecules not coding for proteins
(ncRNAs) has been recognized since the 1950's, but until recently,
aside from the critically important ribosomal and transfer RNA
genes, most focus has been on protein coding genes. However, a long
series of striking discoveries, from RNA's ability to carry out
catalytic function, to discovery of riboswitches, microRNAs and
other ribo-regulators performing critical tasks in essentially all
living organisms, has created a burgeoning interest in this
primordial component of the biosphere. However, the structural
characteristics and evolutionary constraints on RNA molecules are
very different from those of proteins, necessitating development of
a completely new suite of informatic tools to address these
challenges. In RNA Sequence, Structure, Function: Computational and
Bioinformatic Methods, expert researchers in the field describe a
substantial and relevant fraction of these methodologies from both
practical and computational/algorithmic perspectives. Focusing on
both of these directions addresses both the biologist interested in
knowing more about RNA bioinformatics as well as the
bioinformaticist interested in more detailed aspects of the
algorithms. Written in the highly successful Methods in Molecular
Biology series format, the chapters include the kind of detailed
description and implementation advice that is crucial for getting
optimal results. Thorough and intuitive, RNA Sequence, Structure,
Function: Computational and Bioinformatic Methods aids scientists
in continuing to study key methods and principles of RNA
bioinformatics.
The existence of genes for RNA molecules not coding for proteins
(ncRNAs) has been recognized since the 1950's, but until recently,
aside from the critically important ribosomal and transfer RNA
genes, most focus has been on protein coding genes. However, a long
series of striking discoveries, from RNA's ability to carry out
catalytic function, to discovery of riboswitches, microRNAs and
other ribo-regulators performing critical tasks in essentially all
living organisms, has created a burgeoning interest in this
primordial component of the biosphere. However, the structural
characteristics and evolutionary constraints on RNA molecules are
very different from those of proteins, necessitating development of
a completely new suite of informatic tools to address these
challenges. In RNA Sequence, Structure, Function: Computational and
Bioinformatic Methods, expert researchers in the field describe a
substantial and relevant fraction of these methodologies from both
practical and computational/algorithmic perspectives. Focusing on
both of these directions addresses both the biologist interested in
knowing more about RNA bioinformatics as well as the
bioinformaticist interested in more detailed aspects of the
algorithms. Written in the highly successful Methods in Molecular
Biology series format, the chapters include the kind of detailed
description and implementation advice that is crucial for getting
optimal results. Thorough and intuitive, RNA Sequence, Structure,
Function: Computational and Bioinformatic Methods aids scientists
in continuing to study key methods and principles of RNA
bioinformatics.
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