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Biostatistics is the branch of statistics that deals with data
relating to living organisms. This manual is a comprehensive guide
to biostatistics for medical students. Beginning with an overview
of bioethics in clinical research, an introduction to statistics,
and discussion on research methodology, the following sections
cover different statistical tests, data interpretation,
probability, and other statistical concepts such as demographics
and life tables. The final section explains report writing and
applying for research grants and a chapter on 'measurement and
error analysis' focuses on research papers and clinical trials. Key
Points Comprehensive guide to biostatistics for medical students
Covers research methodology, statistical tests, data
interpretation, probability and more Includes other statistical
concepts such as demographics and life tables Explains report
writing and grant application in depth
Inflammation, hypoxia, vascular endothelial growth factor (VEGF)
and chemical mediators play a critical role in pathological
angiogenesis, macular oedema and fibrosis in diabetes. Laser
photocoagulation is still the currently approved gold standard for
treatment of clinically significant macular oedema and
proliferative diabetic retinopathy with strong evidence from large,
multicentric, randomized controlled trials. Emerging treatments
focus on pharmacologic interventions alone or in combination for
improving prognosis. The body of evidence for pharmacologic
interventions is growing and becoming convincing. Specific
inclusion and exclusion criteria, head to head comparisons between
anti VEGF, corticosteroid and laser therapy alone and in
combination are still required for dispassionate scientific
analysis. Our understanding of the mediators is increasing and
novel intervention strategies may be introduced by proteomics.
Combined intervention strategies may become the gold standard in
near future. This book presents the current evidence and emerging
paradigms in pathological ocular angiogenesis and macular oedema in
diabetes. An exciting and enlightening book altogether.
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