The term polycystic ovary syndrome (peOS) is meant to describe a clinical endocrinopathy characterized by menstrual irregularity and evidence of hyperandrogenism. While recognized since the 1800s, a clinical composite was not constructed until 1935 when Stein and Leventhal reported their findings of seven women with infertility, menstrual dysfunction, hirsutism, and enlarged ovaries. Notably, the ovaries contained numerous multiple cysts and the ovarian capsule was thickened. At the time, this preciseness of definition was sufficient to entitle the entity Stein-Leventhal syndrome. Subsequently, over the intervening years as investigators attempted to un ravel the pathophysiology and genesis of this disorder and the number of reported studies increased, there ensued a gradual and distinct terminologic conversion to polycystic ovary syndrome, which, whether intentional or not, connoted a less well-defined condition. Perhaps this is appropriately so, given the seemingly broadening spectrum of clinical presentations and the continuing debate over what constitutes peos. The expansive new knowledge about peos was discussed to a significant degree at an international symposium organized by Serono Symposia USA and held in Boston in the late spring of 1995. Ovarian physiology, including the fate of the follicular unit, was a central focus with several presentations on the genesis, growth, and death of ovarian cellular components. A discus sion of the regulation of ovarian cell function was also highlighted and comprised a major portion of the program."

This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

An engaging undergraduate introduction to the statistical mechanics of phase transitions Statistical mechanics deploys a powerful set of mathematical approaches for studying the thermodynamic properties of complex physical systems. This textbook introduces students to the statistical mechanics of systems undergoing changes of state, focusing on the basic principles for classifying distinct thermodynamic phases and the critical phenomena associated with transitions between them. Uniquely designed to promote active learning, Statistical Mechanics of Phases and Phase Transitions presents some of the most beautiful and profound concepts in physics, enabling students to obtain an essential understanding of a computationally challenging subject without getting lost in the details. Provides a self-contained, conceptually deep introduction to the statistical mechanics of phases and phase transitions from a modern perspective Carefully leads students from spontaneously broken symmetries to the universality of phase transitions and the renormalization group Encourages student-centric active learning suitable for both the classroom and self-study Features a wealth of guided worksheets with full solutions throughout the book that help students learn by doing Includes informative appendixes that cover key mathematical concepts and methods Ideal for undergraduate physics majors and beginning graduate students Solutions manual for all end-of-chapter problems (available only to instructors)