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During the past decade, a wide range of scientific disciplines have
adopted the use of adipose-derived stem/stromal cells (ASCs) as an
important tool for research and discovery. In Adipose-Derived Stem
Cells: Methods and Protocols, experts from the field, including
members of the esteemed International Federation of Adipose
Therapeutics and Science (IFATS), provide defined and established
protocols in order to further codify the utilization of these
powerful and accessible cells. With chapters organized around
approaches spanning the discovery, pre-clinical, and clinical
processes, much of the emphasis is placed on human ASC, while
additional techniques involving small and large animal species are
included. As a volume in the highly successful Methods in Molecular
Biology (TM) series, the detailed contributions include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and notes on troubleshooting and avoiding
known pitfalls. Comprehensive and cutting-edge, Adipose-Derived
Stem Cells: Methods and Protocols serves as a vital reference text
for experienced researchers as well as new students on the path to
further exploring the incredible potential of ASCs.
During the past decade, a wide range of scientific disciplines have
adopted the use of adipose-derived stem/stromal cells (ASCs) as an
important tool for research and discovery. In Adipose-Derived Stem
Cells: Methods and Protocols, experts from the field, including
members of the esteemed International Federation of Adipose
Therapeutics and Science (IFATS), provide defined and established
protocols in order to further codify the utilization of these
powerful and accessible cells. With chapters organized around
approaches spanning the discovery, pre-clinical, and clinical
processes, much of the emphasis is placed on human ASC, while
additional techniques involving small and large animal species are
included. As a volume in the highly successful Methods in Molecular
Biology(TM) series, the detailed contributions include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and notes on troubleshooting and avoiding
known pitfalls. Comprehensive and cutting-edge, Adipose-Derived
Stem Cells: Methods and Protocols serves as a vital reference text
for experienced researchers as well as new students on the path to
further exploring the incredible potential of ASCs.
This reference work presents the origins of cells for tissue
engineering and regeneration, including primary cells,
tissue-specific stem cells, pluripotent stem cells and
trans-differentiated or reprogrammed cells. There is particular
emphasis on current understanding of tissue regeneration based on
embryology and evolution studies, including mechanisms of amphibian
regeneration. The book covers the use of autologous versus
allogeneic cell sources, as well as various procedures used for
cell isolation and cell pre-conditioning , such as cell sorting,
biochemical and biophysical pre-conditioning, transfection and
aggregation. It also presents cell modulation using growth factors,
molecular factors, epigenetic approaches, changes in biophysical
environment, cellular co-culture and other elements of the cellular
microenvironment. The pathways of cell delivery are discussed with
respect to specific clinical situations, including delivery of ex
vivo manipulated cells via local and systemic routes, as well as
activation and migration of endogenous reservoirs of reparative
cells. The volume concludes with an in-depth discussion of the
tracking of cells in vivo and their various regenerative activities
inside the body, including differentiation, new tissue formation
and actions on other cells by direct cell-to-cell communication and
by secretion of biomolecules.
The book deals with both the abstract and practical aspects of
moving from a univerisity laboratory to a position in the biotech
industry. Each chapter lists common and unique features to evaluate
breaking down complex decisions into manageable elements. Several
sections provide "how to" guides for the preparation of
manuscripts, patents, grants, and internal company documents.
*Written by an experienced academician and successful biotechnology
entrepreneur
*Reviews the basic tools taught in a traditional university
*Identifies new ways these these tools will be used in the
corporate world
*Details the 'nuts and bolts' necessary to negotiate a successful
position in the biotech industry
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