This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Basic scientists who are interested in learning more about clinical epileptology, as well as clinicians who would like to understand more about fundamental mechanisms will find this text useful. Residents and postdoctoral fellows, particularly those interested in a career in epilepsy, will benefit from the continuity and organization of this single-authored comprehensive textbook.

Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.  Offers a thorough discussion of epileptic seizure types and epilepsy syndromes, reflecting the latest research and knowledge throughout  Discusses major advances in the understanding of the basic mechanisms of epilepsy and seizures, including an expanded section on their genetic etiologies, their consequences and co-occurring conditions.  Presents state-of-the-art approaches for the diagnostic evaluation of individuals with seizures, pharmacotherapy and alternative treatments, and extensive discussions of the new antiseizure medications for managing seizure intensity and frequency, along with their side effects  Covers the latest developments in surgical approaches to treatment, including neuromodulation  Discusses psychiatric issues associated with epilepsy and conditions resembling seizures.  Presents the current state of global health care delivery for individuals with epilepsy  Shares the knowledge and expertise of contributing authors from 48 countries and nearly 300 institutions    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

Neurobiology of the Epilepsies - From Epilepsy: A Comprehensive Textbook, 3rd Edition, provides a concise, up-to-date review of basic sciences and the latest research advances in epilepsy. Ideal for general neurologists and neurosurgeons, epilepsy/clinical neurophysiology specialists, basic scientists, clinical researchers, and other health care providers with an interest in epilepsy, this new volume by Drs. Istvan Mody, Hal Blumenfeld, Jerome Engel, Jr., Asla Ptkanen, Ivan Soltesz, and Annamaria Vezzani offers comprehensive, authoritative coverage of this critical and complex area of the field. Contains the complete text of Section 3: Neurobiology from Epilepsy: A Comprehensive Textbook, 3rd Edition, by Drs. Jerome Engel, Jr., Solomon L. Moshe, Aristea S. Galanopoulou, and John M. Stern. Offers comprehensive sections on translational aspects of research, neurobiology, recent technical and conceptual advances in research, and other notable contributors to synchrony and seizures Covers major advances in the understanding of the basic mechanisms of epilepsy and its consequences Serves as a source text for translational/basic scientists interested in epilepsy Written and edited by world renowned experts who offer a thorough review of basic sciences and current research in this complex field Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Engel's "Epilepsy Board Quick Review: Selected Tables and Figures from Seizures and Epilepsy" will utilize 86 tables and 47 black and white figures from the "parent book" to provide a quick guide for anyone preparing for the boards. In addition to serving as a board-review guide, this will also be a handy pocket guide for any physician interested in a quick reference to drug tables, signs and symptoms, and other unusual facets of child or adult presenting with seizures. Seizures and Epilepsy, Second Edition has quickly reasserted itself as a modern classic and comprehensive textbook covering a broad range of both basic and clinical epileptology. Singly authored by Jerome Posner, this must-read from 1989 appeals to basic scientists who are interested in learning more about clinical epileptology, as well as clinicians who would like to understand more about fundamental mechanisms will find this text useful. This quick reference guide retains all of the benefits of the classic, in a pared down and easily manageable guide.

A 'generalised seizure' corresponds to an ictal manifestation whose initial semeiology indicates or is consistent with more than minimal involvement of both cerebral hemispheres. A 'network' is a functionally and automatically connected set of cortical and subcortical brain regions in which activity in any one part affects activity in all others. A 'system' is a group of independent but interrelated elements (networks) comprising a unified whole. A considerable amount of evidence supports the existence of cortical and subcortical networks in the genesis, expression and control of generalised seizures. Animal and human data suggested that the so-called generalised seizures involve selective networks while sparing others. A greater understanding of those systems and networks is thoroughly debated in this book.