Cytochrome P450 (CYP) is a super family of phase I enzyme in the biotransformation of xenobiotics and medications. Most medications undergo deactivation by CYP, and then are eliminated through either bile or kidneys from the body. CYP isozymes play a crucial role in drug interactions that may result in enhanced toxicity, reduced efficacy or onset of adverse reactions. On the other hand, many agents affecting CYP expression and activity may alter metabolic rate of different medications co-administrated. Therefore, the molecular basis, regulation by inducers or inhibitors, and pharmacologic reaction of specific CYP isozymes are the key issues of biochemical mechanisms, pharmaceutical development and safe use of various medications. This book is to meet the needs from basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand how an herbal extract, medication or natural supplement is metabolized or transformed in the liver or other sites for deactivation and elimination. Special focuses are paid to herbal extracts and medications in the treatment of neuro-psychiatric or cardiovascular disorders, diabetes and viral hepatitis. Detailed dissection of drug interactions in a particular field intends to provide rationales for useful guidance of safe drug use in daily practice. The contributing authors are basic scientists, pharmacists, pharmacologists and on-service physicians in cardiovascular, neuro-psychiatric, gastroenterologic and hepatologic fields from Europe (Germany, France, Portugal), Australia, the US and China. Thus, the book is the collection of master pieces by well-known experts from various regions of the world, and represents the current understanding of CYP enzyme reaction and a contemporary coverage of possible drug interactions in involved fields. The featured chapters are scientific elucidation of basic biochemistry, pharmacology and clinical investigations in the interest of drug metabolism, interaction and safe use guidance in the single focus of this microsomal enzyme with multi-facet metabolic function.

Hydrodynamic and pollutant transport models are useful tools for evaluating remediation options for polluted water bodies. These models span the range from highly theoretical, fine resolution, physically-based designs to lumped, black-box representations of real world phenomena.
This book examines the numerical approaches used in hydrodynamic and pollutant transport modeling. First, the theory and physical basis of transport and mixing in lakes and coastal waters are provided. Methodologies that use a three-dimensional (3D) approach to predicting the fate and transport of pollutants are presented and this is followed by a presentation of alternatives to 3D circulation modeling as well as new advances in the field. These alternatives offer near 3D accuracy but without the computational burden. Illustrations of the calibration and verification of these models using laboratory data, as well as, field data are also provided. The models are applied to a diverse array of study sites ranging from The Great Lakes in North America to the coastal areas of Northern Crete.
*Presents the theory of hydrodynamic and pollutant transport modelling in lakes and coastal areas
* Thoroughly examines the issues and limitations of the numerical approaches used in hydrodynamic and pollutant transport modelling
* Demonstrates the calibration and verification of hydrodynamic and pollutant transport models using laboratory and field data