Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as applied to the study and practice of pharmacy. Drugs are simply chemicals, so to fully understand their manufacture, formulation, and the way they work in our bodies, a knowledge of organic compounds and their reactions is essential. By reading this book, students will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the text shows how each of these aspects are integrated, helping you to see the bigger picture. Pharmaceutical Chemistry is available for students and institutions to purchase in a variety of formats, and is supported by online resources. The ebook offers a mobile experience and convenient access: www.oxfordtextbooks.co.uk/ebooks. The online resources include: For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter - Bonus material to accompany chapters 3, 7 and 11 - Answers to self-check questions from the book For registered adopters of the book: - Figures from the book, available to download.

Westminster in Old Photographs gives a fascinating insight into the dramatic changes that have occurred in central London over the last 150 years. This fascinating collection of photographs provides an impression of the generations of people who lived and worked here in the late nineteenth and early twentieth centuries, and recalls houses, public buildings, shops, businesses and pubs that have vanished or been altered almost beyond recognition. The pioneering work of early photographers adds a new dimension to our record of the past and brings it vividly back to life. Their pictures document changes in transport and fashion and the evolving characters of streets and districts as they took on the form that is familiar today. The photographs also remember many famous events - funerals, demonstrations, coronations - when the nation's attention was focused firmly on Westminster. Jill Barber has chosen a memorable selection of rare photographs from the City of Westminster Archives Centre to produce this detailed and revealing account of the recent past in the historic centre of the capital. Her book will add to the knowledge, appreciation and enjoyment of all those who take an interest in the development of this remarkable area and the history of London as a whole.