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Primary liver cancer is the third most deadly and fifth most common
cancer worldwide (~500,000 deaths annually), with a sharp increase
of incidence in the United States in recent years. Hepatocellular
carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of
primary liver cancer. Risk factors include gender, hepatitis B
virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism
diseases, diabetes, obesity, toxins, excess alcohol consumption and
smoking. Liver cancer arises most frequently in inflammatory livers
with extensive oxidative stress due to viral hepatitis which causes
over 80% of HCC cases worldwide. Currently, survival remains dismal
for most HCC and CC patients, largely due to the tumor's
aggressiveness at the time of diagnosis and the lack of effective
therapy.
Primary liver cancer is the third most deadly and fifth most common
cancer worldwide (approximately 500,000 deaths annually), with a
sharp increase of incidence in the United States in recent years.
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the
major types of primary liver cancer. Risk factors include gender,
hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis,
metabolism diseases, diabetes, obesity, toxins, excess alcohol
consumption and smoking. Liver cancer arises most frequently in
inflammatory livers with extensive oxidative stress due to viral
hepatitis which causes over 80 per cent of HCC cases worldwide.
Currently, survival remains dismal for most HCC and CC patients,
largely due to the tumor's aggressiveness at the time of diagnosis
and the lack of effective therapy.
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