As he traveled across Germany and the Netherlands and sailed on Dutch and Brandenburg slave ships to the Caribbean and Africa from 1682 to 1696, the young German barber-surgeon Johann Peter Oettinger (1666-1746) recorded his experiences in a detailed journal, discovered by Roberto Zaugg and Craig Koslofsky in a Berlin archive. Oettinger's journal describes shipboard life, trade in Africa, the horrors of the Middle Passage, and the sale of enslaved captives in the Caribbean. Translated here for the first time, A German Barber-Surgeon in the Atlantic Slave Trade documents Oettinger's journeys across the Atlantic, his work as a surgeon, his role in the purchase and branding of enslaved Africans, and his experiences in France and the Netherlands. His descriptions of Amsterdam, Curacao, St. Thomas, and Suriname, as well as his account of societies along the coast of West Africa, from Mauritania to Gabon, contain rare insights into all aspects of Europeans' burgeoning trade in African captives in the late seventeenth century. This journeyman's eyewitness account of all three routes of the triangle trade will be invaluable to scholars of the early modern world on both sides of the Atlantic.

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and prolonging patients lives.

The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The concluding section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotides homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to clinical applications of these experimental therapies. "

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

A perceptive introduction to the mind of one of German's greatest writers, in a new translation for the first time in 150 years 'The best German book there is' Nietzsche By the turn of the nineteenth century, the poet, novelist and thinker Johann Wolfgang von Goethe was one of the most famous people in the world. In 1823 he became friend and mentor to the young writer Johann Eckermann, who, for the last nine years of Goethe's life, recorded their wide-ranging conversations on art, literature, science and philosophy. This rich portrait of Germany's literary elder statesman, now in its first new translation for over 150 years, gives a fascinating glimpse into a great mind as well as 'many insights and invaluable lessons about life.' Translated by Allan Blunden with an Introduction by Ritchie Robertson

Johannes Peter legt seiner Studie die These zugrunde, dass durch ein optimal ausgelegtes Turbinenrad die Leistungscharakteristik des Motors signifikant verbessert werden kann, ohne auf Zusatzmassnahmen angewiesen zu sein. Basierend auf CFD-Simulationen erarbeitet der Autor zu diesem Zweck ein Verfahren zur Optimierung des Wirkungsgrades und des Massentragheitsmoments der Turbine. Zur Durchfuhrung der Simulationen entwickelt er ein parametrisiertes CAD-Modell des Turbinenrades, welches die Darstellung von Radialturbinen uber Mixed-flow-Turbinen bis hin zu Axialturbinen ermoeglicht. Er zeigt, dass eine zentrale Strategie bei der Entwicklung von immer effizienteren Verbrennungsmotoren die Steigerung des Aufladegrades darstellt und hierbei der Turbine eines Abgasturboladers eine entscheidende Bedeutung zukommt.