This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.

In the drowsy tranquility of Little Belaire, the Truthful Speakers lead lives of peaceful self-sufficiency ignoring the depopulated wilderness beyond their narrow borders. It is a society untouched by pain or violence and the self-destroying 'Angels' of the past are barely remembered. But when Rush That Speaks leaves his home on a pilgrimage of self-enlightenment, he finds a landscape haunted by myths and memories. The overgrown ruins reflect a world outside that is stranger than his people ever dreamed ...

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

John Crowley's masterful "Little, Big" is the epic story of Smoky Barnable, an anonymous young man who travels by foot from the City to a place called Edgewood--not found on any map--to marry Daily Alice Drinkawater, as was prophesied. It is the story of four generations of a singular family, living in a house that is many houses on the magical border of an otherworld. It is a story of fantastic love and heartrending loss; of impossible things and unshakable destinies; and of the great Tale that envelops us all. It is a wonder.

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research.

Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts:

• Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.
• Phase II trials Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.
• Phase III trials Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.
• Exploratory and high-dimensional data analyses All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.

Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Edgewood is many houses, all put inside each other, or across each other. It's filled with and surrounded by mystery and enchantment: the further in you go, the bigger it gets. Smoky Barnable, who has fallen in love with Daily Alice Drinkwater, comes to Edgewood, her family home, where he finds himself drawn into a world of magical strangeness. Crowley's work has a special alchemy - mixing the world we know with an imagined world which seems more true and real. Winner of the WORLD FANTASY AWARD, LITTLE, BIG is eloquent, sensual, funny and unforgettable, a true Fantasy Masterwork. Winner of the WORLD FANTASY AWARD FOR BEST NOVEL, 1982.

The Atlas of the Irish Revolution is a landmark publication that presents scholarship on the revolutionary period in a uniquely accessible manner. Featuring over 200 original maps and 300 images, the Atlas includes 120 contributions by leading scholars from a range of disciplines. They offer multiple perspectives on the pivotal years from the 1912 Home Rule crisis to the end of the Irish Civil War in 1923. Using extensive original data (much of it generated from newly-released archival material), researchers have mapped social and demographic change, political and cultural activity, state and non-state violence and economic impacts. The maps also portray underlying trends in the decades before the revolution and capture key aspects of the revolutionary aftermath. They show that while the Irish revolution was a 'national' event, it contained important local and regional variations that were vital to its outcomes. The representation of island-wide trends stand alongside street-level, parish, county and provincial studies that uncover the multi-faceted dynamics at play.The Atlas also captures the international dimensions of a revolution that occurred amidst the First World War and its tumultuous aftermath. Revolutionary events in Ireland received global attention because they profoundly challenged the British imperial project. Key revolutionaries operated transnationally before, during and after the conflict, while the Irish diaspora provided crucial support networks. The often neglected roles of women and workers are illuminated, while commentators consider the legacies of the revolution, including collective memories, cultural representations and historical interpretations. The Atlas of the Irish Revolution brings history to life for general readers and students, as well as academics. It represents a ground-breaking contribution to the historical geography of these compelling years of conflict, continuity and change.

A master literary stylist, John Crowley has carried readers to diverse and remarkable places in his award-winning, critically acclaimed novels -- from his classic fable, Little, Big, to his New York Times Notable Book, The Translator. Now, for the first time, all of his short fiction has been collected in one volume, demonstrating the scope, the vision, and the wonder of one of America's greatest storytellers. Courage and achievement are celebrated and questioned, paradoxes examined, and human frailty appreciated in fifteen tales, at once lyrical and provocative, ranging fromthe fantastic to the achingly real. Be it a tale of an expulsion from Eden, a journey through time, the dreams of a failed writer, ora dead woman's ambiguous legacy, each story in Novelties & Souvenirs is a glorious reading experience, offering delights to be savored ...and remembered.

Praise for John Crowley: "Like a magus, John Crowley shares his secrets generously, allowing us to believe that his book is revealing the true and glorious nature of the world and the reader's own place within it."—Village Voice "[Crowley] transforms the lead of daily life into seriously dazzling artistic gold."—Newsday Often de-scribed as an alchemical allegory, John Crowley instead decided this is "the first science fiction novel." After all "it's fiction; it's about the possibilities of a science; and it's a novel." No matter what else it might be, it's definitely "one of the great outlandish stories in Western literature." With eight appropriately weird and fascinating black and white woodcuts by Theo Fadel. John Crowley was born in Presque Isle, Maine, in 1942. He moved to New York City after college in Indiana to make movies, and did find work in docu-mentary films, an occupation he still pursues. He has published many novels including the Ae-gypt quartet and Little, Big. He teaches creative writing at Yale University. In 1992 he received the Award in Literature from the American Academy and Institute of Arts and Letters. He finds it more gratifying that almost all his work is still in print. Theo Fadel has a BA in Archeology (Bryn Mawr) and a Master of Architecture from Co-lumbia University. Currently her studio is in Easthampton, and she's been in Massachusetts less than a hundred years. This is the first book she has illustrated.

There is more than one history of the world. Before science defined the modern age, other powers, wondrous and magical, once governed the universe, their lore perfected within a lost capital of hieroglyphs, wizard-kings, and fabulous monuments. In the 1970s, a historian named Pierce Moffett moves to the New England countryside to write a book about AEgypt, driven by an idea he dare not believe: that the physical laws of the universe once changed and may change again. Yet the notion is not his alone. Something waits at the locked estate of Fellowes Kraft, author of romances about Will Shakespeare and Giordano Bruno and Dr. John Dee, something for which Pierce and those near him have long sought without knowing it: a key, perhaps, to AEgypt ... Shortlisted for the WORLD FANTASY and ARTHUR C. CLARKE AWARDs.

This book explores the Skelligs, Ireland's most dramatic and beautiful Atlantic islands, and focuses particularly on Skellig Michael, a famous UNESCO World Heritage Site. It considers why the construction of a remarkable monastic site near the peak of this island over a thousand years ago stands as one of the most remarkable achievements in the history of Christianity. The Book of the Skelligs combines different approaches to deepening our understanding of the islands, combining the perspectives of history, archaeology, cultural geography, oral tradition, literature and natural science. It interprets distinctive features, both physical and human, that shape the unique character of these islands while also exploring their geology, marine and terrestrial life as well as the historical background and cultural setting of Skellig Michael's monastic remains. It also considers the impact of the Vikings, and the construction of lighthouses a millennium later. Drawing on appropriate disciplines, the book reveals how a unique cultural landscape was generated by human activities over long periods of time. The editors and contributors have incorporated a wide range of illustrative material including maps, paintings, and photographs throughout the book, many of which have not been published before. It comprises over forty individual chapters and case studies in which the work of academics and independent scholars is combined with that of poets and artists to provide a wide range of perspectives on Skelligs' distinctive character - both natural and human - during different periods. The aim of the editors is to produce a well-informed, accessible, highly readable, and generously illustrated volume that succeeds in conveying a true sense of the cultural richness and complexity of these remarkable islands. The blend of text and images is an important part of the book, making it both suitable for the general reader and a wide range of teaching programmes.

Best Reference Books of 2012 presented by Library Journal The Great Irish Famine is the most pivotal event in modern Irish history, with implications that cannot be underestimated. Over a million people perished between 1845-1852, and well over a million others fled to other locales within Europe and America. By 1850, the Irish made up a quarter of the population in Boston, New York City, Philadelphia, and Baltimore. The 2000 US census had 41 million people claim Irish ancestry, or one in five white Americans. Atlas of the Great Irish Famine (1845-52) considers how such a near total decimation of a country by natural causes could take place in industrialized, 19th century Europe and situates the Great Famine alongside other world famines for a more globally informed approach. The Atlas seeks to try and bear witness to the thousands and thousands of people who died and are buried in mass Famine pits or in fields and ditches, with little or nothing to remind us of their going. The centrality of the Famine workhouse as a place of destitution is also examined in depth. Likewise the atlas represents and documents the conditions and experiences of the many thousands who emigrated from Ireland in those desperate years, with case studies of famine emigrants in cities such as Liverpool, Glasgow, New York and Toronto. The Atlas places the devastating Irish Famine in greater historic context than has been attempted before, by including over 150 original maps of population decline, analysis and examples of poetry, contemporary art, written and oral accounts, numerous illustrations, and photography, all of which help to paint a fuller picture of the event and to trace its impact and legacy. In this comprehensive and stunningly illustrated volume, over fifty chapters on history, politics, geography, art, population, and folklore provide readers with a broad range of perspectives and insights into this event.

The Great Famine is possibly the most pivotal event/experience in modern Irish history. Its global reach and implications cannot be underestimated. In terms of mortality, it is now widely accepted that over a million people perished between the years 1845-1852 and at least one million and a quarter fled the country, the great majority to North America, some to Australia and a significant minority ((0.3 million) to British cities. Ireland had been afflicted by famine before the events of the 1840s; however the Great Famine is marked by both its absolute scale and its longevity. It is also better remembered because it was the most recent and best documented famine. This atlas comprising over fifty individual chapters and case studies will provide readers with a broad range of perspectives and relevant insights into this tragic event. The atlas begins by acknowledging the impossibility of adequately representing the Great Famine or any major world famine. Yet by exploring a number of themes from a reconstruction of pre-Famine Ireland onwards to an exploration of present-day modes of remembering; by the use of over 150 highly original computer generated parish maps of population decline, social transformation and other key themes between the census years 1841 and 1851: and through the use of poetry, contemporary paintings and accounts, illustrations and modern photography, what this atlas seeks to a achieve is a greater understanding of the event and its impact and legacy. This atlas seeks to try and bear witness to the thousands and thousands of people who died and are buried in mass Famine pits or in fields and ditches, with little or nothing to remind us of their going. The centrality of the Famine workhouse as a place of destitution is also examined in depth. Likewise the atlas seeks to represent and understand the conditions and experiences of the many thousands who emigrated from Ireland in those desperate years. Included are case studies of famine emigrants in cities such as Liverpool, Glasgow, New York and Toronto. A central concern of the atlas is to seek to understand why a famine of this scale should occur in a nineteenth-century European country, albeit a country which was subject to imperial rule. In addition, it seeks to reveal in detail the working-out and varying consequences of the Famine across the island. To this end, apart from presenting an overall island-wide picture, Famine experiences and patterns will be presented separately for the four provinces. These provincial explorations will be accompanied by intimate case studies of conditions in particular localities across the provinces. The atlas also seeks to situate the Great Irish Famine in the context of a number of world famines. To achieve these goals and understandings, the atlas includes contributions from a wide range of scholars who are experts in their fields - from the arts, folklore, geography, history, archaeology, Irish and English languages and literatures.

Compiling scholarly essays from a unique three-year Democracy, Culture and Catholicism International Research Project, Democracy, Culture, Catholicism richly articulates the diverse and dynamic interplay of democracy, culture, and Catholicism in the contemporary world. The twenty-five essays from four extremely diverse cultures-those of Indonesia, Lithuania, Peru, and the United States-explore the relationship between democracy and Catholicism from several perspectives, including historical and cultural analysis, political theory and conflict resolution, social movements and Catholic social thought.

Compiling scholarly essays from a unique three-year Democracy, Culture and Catholicism International Research Project, Democracy, Culture, Catholicism richly articulates the diverse and dynamic interplay of democracy, culture, and Catholicism in the contemporary world. The twenty-five essays from four extremely diverse cultures—those of Indonesia, Lithuania, Peru, and the United States—explore the relationship between democracy and Catholicism from several perspectives, including historical and cultural analysis, political theory and conflict resolution, social movements and Catholic social thought.

For many generations the Just have been at war with the Protectors. In their strange world, supported by a huge pillar poised in the vast and mysterious Deep, ritual bloodshed and sorcery have obsessed the inhabitants since the beginning of time. Half human, half machine, sexless and hairless, the Visitor from the skies enters the world on a mission unknown even to himself. Is he a peacemaker between the warrior clans, an observer, or, with his phenomenal qualities, a warrior himself, the likes of which this planet has never seen before? Only time can tell, and time is something that his makers have not allowed for ...

In the early years of the 1940s, as the nation's young men ship off to combat, a city springs up, seemingly overnight in the fields of Oklahoma: the Van Damme airplane factory, a gargantuan complex dedicated to the construction of the necessary machinery of warfare. Laborers--mostly women--flock to this place, enticed by the opportunity to be something more than wife and homemaker. For Vi, fleeing a dying ranch; for Connie, following an unfaithful husband; for Diane, leaving behind the hot music and soldier boys to pursue something different, adult, and real; their journeys will be liberating in ways they couldn't previously imagine, and it will lead each of them to Prosper Olander--disabled artist, forger, friend, lover, and the true heart and soul of the temporary city--who will change their lives in profound and unexpected ways.

A novel of tremendous scope and beauty, The Translator tells of the relationship between an exiled Russian poet and his American translator during the Cuban missile crisis, a time when a writer's words -- especially forbidden ones -- could be powerful enough to change the course of history.

The Deep

In a twilight land, two warring powers -- the Reds and the Blacks -- play out an ancient game of murder and betrayal. Then a Visitor from beyond the sky arrives to play a part in this dark and bloody pageant. From the moment he is found by two women who tend to the dead in the wake of battles, it is clear that the great game is to change at last.

Beasts

It is the day after tomorrow, and society has been altered dramatically by experimentation that enables scientists to combine the genetic material of different species, mixing DNA of humans with animals. Loren Casaubon is an ethologist drawn into the political and social vortex that results with Leo -- a creature both man and lion -- at its center.

Engine Summer

A young man named Rush That Speaks is growing up in a far distant world -- one that only dimly remembers our own age, the wondrous age of the Angels, when men could fly. Now it is the "engine summer of the world," and Rush goes in search of the Saints who can teach him to speak truthfully, and be immortal in the stories he tells. The immortality that awaits him, though, is one he could not have imagined.

This collection of four never-before-published, superbly crafted novellas, includes: Why the Nightingale Sings at Night, Great Work of Time, In Blue and Novelty.

The Iveragh Peninsula, often referred to as the 'Ring of Kerry', is one of Ireland's most dramatic and beautiful landscapes. This cultural atlas, comprising over fifty individual chapters and case studies, provides the reader with a broad range of perspectives on the peninsula and the human interactions with it since prehistoric times to the present day. Although not a conventional atlas, it contains many historic and newly commissioned maps. It also combines many different approaches towards understanding the distinctive character - both physical and human - of this unique landscape.The opening chapters explore the physical and environmental setting of the peninsula. Subsequent chapters deal with its development over the millennia and the influences that have shaped it. All aspects of Iveragh's past and present are considered, using the evidence of disciplines such as archaeology, art-history, cartography, folklore, geography, geology, history, mythology and zoology. The range of topics that arise from this approach is tremendously wide, and occasionally surprising.Given its status as a peninsula projecting into the Atlantic, the history and culture of the Iveragh Peninsula have been moulded by external influences as well as by regional and national ones. Its story is multi-layered, involving the imprint of mythological as well as historic settlers and invaders. The peninsula has witnessed significant periods of transition, perhaps none more so than in the present era. This book seeks to deepen and illuminate our understanding of its landscape, history and heritage.

One of our most accomplished literary artists, John Crowley imagines the novel the haunted Romantic poet Lord Byron never penned ...but very well might have. Saved from destruction, read, and annotated by Byron's own abandoned daughter, Ada, the manuscript is rediscovered in our time -- and almost not recognized. Lord Byron's Novel is the story of a dying daughter's attempt to understand the famous father she longed for -- and the young woman who, by learning the secret of Byron's manuscript and Ada's devotion, reconnects with her own father, driven from her life by a crime as terrible as any of which Byron himself was accused.