This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.

Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.

As early as the eighteenth century, Spanish explorers left place-names, lost mines, and legends scattered throughout Colorado's San Juan Mountains. In 1869 and the early 1870s the legends lured hopeful prospectors to the area, ushering in its greatest mining era and transforming it into one of the country's most celebrated mining districts. Faced with a boom-bust economy, unpredictable weather, and the risk of violent death, mining camps and towns nevertheless struggled to institute local governments that would address issues such as sanitation, the maintenance of schools, and the enforcement of law and order.
As the economic boom headed toward its inevitable decline, towns like Silverton, Ouray, Telluride, Creede, Lake City, and Rico found themselves seeking visitors and tourists who wanted to experience the historical West and its accompanying folklore and legend. The pioneers and mining communities were supplanted in that rugged and unforgiving terrain. In this history of the San Juan mining region, Duane Smith's text and John Ninnemann's photographs offer a glimpse into the lives of towns that sprang up in remote canyons and mountain plateaus in southwestern Colorado and the settlers who attempted to recreate the eastern communities they had left behind.

This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.