This study looks at the way the products of arachidonic acid
metabolism are active both in normal and abnormal immune responses.
While some of the fundamental issues such as whether lymphocytes
are capable of producing prostaglandins and leukotrienes are still
hotly debated, the evidence is overwhelming that many specific
immunological problems and disease states are associated with
alterations in the normal balance of arachidonic acid metabolism.
This book provides a review of the history and chemistry of the
arachidonic acid cascade as well as an exhaustive survey of the
literature concerning the interaction of arachidonic acid
metabolites with cells of the immune system. The author also
presents and discusses the evidence demonstrating prostaglandin and
leukotriene participation in response to injury and in malignancy,
tissue and organ rejection, rheumatoid arthritis, autoimmunity and
allergy.
General
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