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This volume is the fourth in a series on depressive illness. The
first volume, entitled Phenomenology of Depressive Illness, is
devoted to a de- scription of depressive illness from a variety of
perspectives that include that of the patient, the clinician, and
the psychiatric researcher. It de- scribes the major subtypes of
depressive illness and places them in the context of the life
cycle. The second volume in this series is entitled Models of
Depres- sive Disorders: Psychological, Biological, and Genetic
Perspectives. This volume describes several major models of
depressive disorders, in- cluding genetic, cognitive,
interpersonal, intrapsychic, and neurobio- logical models. The
third and fourth volumes deal with the biology of affective
disorders in detail. These volumes are distinguished by a triaxial
ap- proach. In Volume III the biology of affective disorders is
described from the perspective of individual transmitter systems
and neurophysio- logic and biologic processes. In Volume IV the
biology of depression is addressed from the vantage point of
symptom components of de- pression, and similarities and
differences in the biology of depression are described compared to
other psychiatric disorders with clini- cally overlapping features
such as anxiety disorders or eating disor- ders. The effects on
biology of comorbid conditions such as anxiety, personality
disorders, alcoholism, and eating disorders are reviewed.
This volume is the third in a series on depressive illness. The
first volume, entitled Phenomenology of Depressive Illness, is
devoted to a de scription of depressive illness from a variety of
perspectives that include those of the patient, the clinician, and
the psychiatric researcher. It de scribes the major subtypes of
depressive illness and places them in the context of the life
cycle. The second volume in this series is entitled Models of
Depres sive Disorders: Psychological, Biological, and Genetic
Perspectives. This volume describes several major models of
depressive disorders, in cluding genetic, cognitive, interpersonal,
intrapsychic, and neurobio logical models. The third and fourth
volumes deal with the biology of affective disorders in detail.
These volumes are distinguished by a triaxial ap proach. In Volume
III the biology of affective disorders is described from the
perspective of individual transmitter systems and neurophysi ologic
and biologic processes. In Volume IV the biology of depression is
addressed from the vantage point of symptom components of de
pression, and similarities and differences in the biology of
depression are described compared to other psychiatric disorders
with clinically overlapping features such as anxiety disorders or
eating disorders. The effects on biology of comorbid conditions
such as anxiety, personal ity disorders, alcoholism, and eating
disorders are reviewed. These ap proaches incorporate issues of
state versus trait."
Absinthe, LSD, Speed and anti-cancer drugs - these three
entertaining stories explore how drugs, both legal and otherwise,
can affect the lives of those who make them and those who use them.
The author, a former professor of chemistry, has previously written
three popular science books: Murder, Magic and Medicine, the
Elusive Magic Bullet and Chasms of Delight (also published by
Memoirs). This is his first work of fiction.
Long out-of-print yet often cited in psychedelic literature, THE
BOOK OF SACRAMENTS, originally published in 1970, was a Holy book
from the (now defunct) Church of the Tree of Life, established and
incorporated by John Mann. A fundamental belief was that we have
the right to alter our consciousness with plants extracts for
medical, spiritual, and even recreational (re-creating) purposes.
THE BOOK OF SACRAMENTS consists of introduction and discussion of
several sacred plants, most still legal and easy to obtain, that
have been used traditionally in religious (spiritual, consciousness
expanding) rituals by native people. While the Church of the Tree
of Life disbanded decades ago, the longing for a spiritual
connection continues. One way to achieve such a connection with
with the ritual use of magical plants. THE BOOK OF SACRAMENTS
describes the ceremonial practices and rituals used by natives for
thousands of years in some cases and gives guidelines for employing
such practices in one's personal worship, including how to prepare
the plant and oneself for the ritual. The mind has self-healing
power. Spiritual experiences can lead to dramatic healing. Ritual
is a method for organizing experience - mentally- and creating
order around an inner experience to enable one to surrender to the
experience without fear - due to the security provided by the
repetitive and reliable ritual. The ritual helps to conjure up a
frame of mind that is conducive to an ecstatic experience. When
used properly ritual use of magical plants can open up new channels
of awareness. The plants alone cannot bring about the desired
results - the individual mind must be engaged. THE BOOK OF
SACRAMENTS identifies over 20 magical plants for ritual use and
tells how to prepare the potion and oneself for the journey and
gives instructions for classic rituals as well as creating one's
own variations. Finally it discusses how to process the experience
afterwards to gain the maximum benefit from the journey.
In 1900 only a handful of drugs (morphine, quinine, aspirin, etc)
had genuine efficacy but had little value for bacterial or viral
infections or cancer. These conditions were usually untreatable.
Now there are literally thousands of drugs which offer cures or
greatly extended life-spans for those with life-threatening
conditions. Life Saving Drugs: the Elusive Magic Bullet describes
the discovery and development of antibacterial, anti-viral and
anti-cancer drugs. The book highlights the colourful characters
behind the inventions and the huge improvements in quality of life
and life-expectancy that these drugs have produced. Emphasis is
given to the new drugs that have emerged as a result of knowledge
of the human genome, and the ways in which the newer drugs are
being designed to tackle disease, particularly cancer, at the
genetic level. Chemical structures are provided for all of the key
drugs and the book is well illustrated. Life Saving Drugs: the
Elusive Magic Bullet can be read as a history of drug development
during the past 100 years by those with only a passing knowledge of
chemistry. For anyone entering the medical profession, pharmacy, or
nursing, it will provide a superb basic knowledge of all drugs they
are ever likely to meet, including their modes of action. For the
chemist or medicinal chemist, it will provide the fundamental
knowledge of life-saving drugs that they all should know. And for
the non-scientist who wants to know about 'super-bugs', SARS,
Ebola, and all of the wonderful advances in treating cancer, it is
illuminating and easy to read.
'Chasms of Delight' is rooted in chemist John Mann's fascination
with psychedelic, narcotic and euphoriant drugs. He sets out a
colourful history of their discovery and use, telling the story of
mind-altering drugs, their contribution to the work of poets and
artists, the iniquities of the drug trade and the popular use of
drugs in the 60s and 70s. Timothy Leary's famous exhortation in
1968 to 'turn on, tune in, drop out' has been blamed for persuading
the masses to play with drugs, but the truth is that by the time of
the 'Summer of Love' we had already been experimenting with them
for thousands of years. Now chemist John Mann has responded to the
continuing fascination with psychedelic, narcotic and euphoriant
substances by setting out a fascinating and colourful history of
their discovery and use. This book tells the story of mind-altering
drugs over the centuries, from the poets and artists who produced
their work under the influence of opium to the posturing of modern
politicians, the iniquities of the international drug trade and the
wild excesses of the 1960s and 70s. Previous books by John Mann
include Murder, Magic and Medicine published in 1992 and The
Elusive Magic Bullet published in 1999, both by Oxford University
Press.
This volume is the fourth in a series on depressive illness. The
first volume, entitled Phenomenology of Depressive Illness, is
devoted to a de- scription of depressive illness from a variety of
perspectives that include that of the patient, the clinician, and
the psychiatric researcher. It de- scribes the major subtypes of
depressive illness and places them in the context of the life
cycle. The second volume in this series is entitled Models of
Depres- sive Disorders: Psychological, Biological, and Genetic
Perspectives. This volume describes several major models of
depressive disorders, in- cluding genetic, cognitive,
interpersonal, intrapsychic, and neurobio- logical models. The
third and fourth volumes deal with the biology of affective
disorders in detail. These volumes are distinguished by a triaxial
ap- proach. In Volume III the biology of affective disorders is
described from the perspective of individual transmitter systems
and neurophysio- logic and biologic processes. In Volume IV the
biology of depression is addressed from the vantage point of
symptom components of de- pression, and similarities and
differences in the biology of depression are described compared to
other psychiatric disorders with clini- cally overlapping features
such as anxiety disorders or eating disor- ders. The effects on
biology of comorbid conditions such as anxiety, personality
disorders, alcoholism, and eating disorders are reviewed.
This volume is the second in a series on depressive illness. The
first volume, entitled Phenomenology of Depressive Illness, is de
voted to a description of depressive illness from many vantage
points including that of the patient as well as the psychiatrist.
Epidemiological, nosological, and developmental aspects are
included together with specific descriptions of major subtypes of
depressive illness. It is only after an illness is fully described
that an attempt should be made to generate models with ex planatory
and predictive properties. This second volume is that next step.
The major models of depressive illness are described. The limited
progress that has been made in integrating these models is
discussed, but with further knowledge, this will change. Each model
has different advantages and may apply more directly to different
subtypes of depressive illness. Such refinements also await the
results of future studies. However, the heuristic and clinical
usefulness of the models described is considerable and will inform
the reader about the current state of knowledge regarding the
etiology and pathogenesis of de pressive illness and directions of
future research. J. John Mann, M.D. New York vii ACKNOWLEDGMENTS
This volume would not have been possible without the support of my
wife and children who permitted me the time to work on it. Ms.
Renee Azima-Heller assisted greatly in the organi zation of the
material for the book. A career scientist award from the Irma T.
HirschI Trust provided support for this work."
This volume is the third in a series on depressive illness. The
first volume, entitled Phenomenology of Depressive Illness, is
devoted to a de scription of depressive illness from a variety of
perspectives that include those of the patient, the clinician, and
the psychiatric researcher. It de scribes the major subtypes of
depressive illness and places them in the context of the life
cycle. The second volume in this series is entitled Models of
Depres sive Disorders: Psychological, Biological, and Genetic
Perspectives. This volume describes several major models of
depressive disorders, in cluding genetic, cognitive, interpersonal,
intrapsychic, and neurobio logical models. The third and fourth
volumes deal with the biology of affective disorders in detail.
These volumes are distinguished by a triaxial ap proach. In Volume
III the biology of affective disorders is described from the
perspective of individual transmitter systems and neurophysi ologic
and biologic processes. In Volume IV the biology of depression is
addressed from the vantage point of symptom components of de
pression, and similarities and differences in the biology of
depression are described compared to other psychiatric disorders
with clinically overlapping features such as anxiety disorders or
eating disorders. The effects on biology of comorbid conditions
such as anxiety, personal ity disorders, alcoholism, and eating
disorders are reviewed. These ap proaches incorporate issues of
state versus trait.
Timothy Leary's advice to "tune in, turn on and drop out" was a
1960s exhortation to experiment with LSD, but humans had been
consuming ergot alkaloids related to lysergic acid diethylamide for
at least a thousand years. Opium has been around even longer with
its medicinal uses being known to the Ancient Sumerians as long ago
as 3400 BC. This is the first book to cover all of the major
psychoactive drugs (both natural and synthetic) in one volume, and
the only one to cover all aspects of these drugs from their
anthropological and sociological influences through to their
chemistry and pharmacology. It covers a range of substances
including LSD, opium, heroin, cocaine, cannabis, peyote,
belladonna, mandrake, and absinthe. The book is highly readable and
concentrates on the characters (e.g. authors, painters, pop stars,
hippies, politicians and drug barons), both famous and infamous,
who have ensured that psychoactive drugs hold an enduring
fascination and interest for everyone. The basic chemistry and
pharmacological activity covered together with a brief account of
useful drugs that have emerged from a study of the psychoactive
ones.
This clear, straightforward text provides a concise yet comprehensive introduction to the chemistry involved in the biosynthesis of natural products. It explains the connections between the primary and secondary metabolites, outlines the chemistry mediated by the major enzyme cofactors, and describes the methods for the elucidation of biosynthetic pathways. The different classes of metabolites are then discussed, with an emphasis on the pharmacological and toxicological significance of the various compounds. The ecological significance of a wide variety of natural products is also examined.
Journeying to the Light is intended to be read daily through the
period from Advent Sunday to the Epiphany. It is largely
based upon one of the Eucharistic readings each day. There
are variations, and it can be adapted to be used whatever the
length of Advent, and for individual or group use. The
author weaves contemporary trends with biblical themes and with
events of his own life. It has at its heart the Incarnation;
anticipated by the prophets; joyfully experienced through the words
of Luke, and proclaimed to the nations through the visit of the
Magi, as recorded by Matthew.Â
          Â
The author is an Anglican priest, but as this book is based upon
the the Revised
                                    Â
Common Lectionary, it is ecumenical in its reach, as many of the
readings coincide with those appointed for both the daily Mass in
Roman Catholic Churches and in Anglican Churches. Equally,
the daily reflections, may be of use to all individuals who are
seeking to establish a regular period of contemplation and space
through Advent and  Christmas, which is traditionally
full of distraction and busyness. Â Bishop Brendan Leahy is
joined by Archbishop John McDowell of the Church of Ireland in
commending the book for our use, and two Church of England bishops
add their voices to suggest that a deepening of our reflection,
throughout these days of joyous hope, helps us to seek further the
source of the light that was coming to  Â
   humanity, that is Jesus, son of Mary,
redeemer of the world. Â A Church-goer, a seeker after truth
or, quite possibly in these tumultuous days, a Christian soul whose
path has become darkened or distracted in recent years will find
some thing in these pages to encourage them beyond written texts of
any kind to set their eyes towards the light and their heart to the
divine.
John Mann is an archivist of the human heart and an accountant both
of the natural world and popular culture. His precisely observed
juxtapositioning of these in Able, Baker, Charlie never fails to
surprise, never fails to move us. As Rilke advised readers to
change our lives, so does Mann often build toward the insistent, as
in "Hand over your dearest songs"-advice which the poet himself has
surely heeded in this marvelous collection. -David Stevenson John
Mann's poems approach you not like the lantern that you plod
towards through darkness, but like fireflies appearing at different
points within the range of your vision that engage your every
sense, enough for you to make sense of the journey you take through
his unsettling, elliptical world. They seem to be written in
outlying areas where the usual compasses and watches will not
serve, but they will so thoroughly claim you that you may find that
you have suspended your breathing. George Ellenbogen We have fooled
ourselves into thinking that pain is simple-it is emptiness, a
chasm. But John Mann's poetry shows loss with all of its lurid
filigree, its barbed-wire curlicues. Mann probes this "atmosphere
of void covered with frost" throughout Able, Baker, Charlie, and he
manages to capture how we leave this void changed. There is no
mitigating agent. Even love is defined as "the heart outside the
body." Beauty is something that leaks from the eyes, and the sky
"vomits its stars." Able, Baker, Charlie is a beautiful, painful
read-more acute because of its dead-eye accuracy. -Karen Craigo,
Mid-American Review John Mann is the author of Wyoming, a chapbook
of poems (Finishing Line Press, 2008). His poems have appeared in
Alaska Quarterly Review, Fence, Conduit, Massachusetts Review,
Mid-American Review, The National Poetry Review, Vallum,
Crazyhorse, and The Gettysburg Review. He won a Poetry Fellowship
from the Illinois Arts Council and a resident fellowship from the
Virginia Center for the Creative Arts. He taught creative writing
at Western Illinois University and edited The Mississippi Valley
Review.
Yale University Publications In Anthropology, No. 41-42. Edited By
Irving Rouse.
Yale University Publications In Anthropology, No. 41-42. Edited By
Irving Rouse.
Yale University Publications In Anthropology, No. 47.
Yale University Publications In Anthropology, No. 47.
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