Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes.

In the era of information and communication, issues of misinformation and miscommunication are more pressing than ever. Epistemic injustice - one of the most important and ground-breaking subjects to have emerged in philosophy in recent years - refers to those forms of unfair treatment that relate to issues of knowledge, understanding, and participation in communicative practices. The Routledge Handbook of Epistemic Injustice is an outstanding reference source to the key topics, problems and debates in this exciting subject. The first collection of its kind, it comprises over thirty chapters by a team of international contributors, divided into five parts: Core Concepts Liberatory Epistemologies and Axes of Oppression Schools of Thought and Subfields within Epistemology Socio-political, Ethical, and Psychological Dimensions of Knowing Case Studies of Epistemic Injustice. As well as fundamental topics such as testimonial and hermeneutic injustice and epistemic trust, the Handbook includes chapters on important issues such as social and virtue epistemology, objectivity and objectification, implicit bias, and gender and race. Also included are chapters on areas in applied ethics and philosophy, such as law, education, and healthcare. The Routledge Handbook of Epistemic Injustice is essential reading for students and researchers in ethics, epistemology, political philosophy, feminist theory, and philosophy of race. It will also be very useful for those in related fields, such as cultural studies, sociology, education and law.

"A theory in the flesh means one where the physical realities of our lives all fuse to create a politic born of necessity," writes activist Cherrie L. Moraga. This volume of new essays stages an intergenerational dialogue among philosophers to introduce and deepen engagement with U.S Latinx and Latin American feminist philosophy, and to explore their "theories in the flesh." It explores specific intellectual contributions in various topics in U.S. Latinx and Latin American feminisms that stand alone and are unique and valuable; analyzes critical contributions that U.S. Latinx and Latin American interventions have made in feminist thought more generally over the last several decades; and shows the intellectual and transformative value of reading U.S Latinx and Latin American feminist theorizing. The collection features a series of essays analyzing decolonial approaches within U. S. Latinx and Latin American feminist philosophy, including studies of the functions of gender within feminist theory, everyday modes of resistance, and methodological questions regarding the scope and breadth of decolonization as a critical praxis. Additionally, essays examine theoretical contributions to feminist discussions of selfhood, narrativity, and genealogy, as well as novel epistemic and hermeneutical approaches within the field. A number of contributors in the book address themes of aesthetics and embodiment, including issues of visual representation, queer desire, and disability within U. S. Latinx and Latin American feminisms. Together, the essays in this volume are groundbreaking and powerful contributions in the fields of U.S Latinx and Latin American feminist philosophy.

This book explores the epistemic side of oppression, focusing on racial and sexual oppression and their interconnections. It elucidates how social insensitivities and imposed silences prevent members of different groups from interacting epistemically in fruitful ways-from listening to each other, learning from each other, and mutually enriching each other's perspectives. Medina's epistemology of resistance offers a contextualist theory of our complicity with epistemic injustices and a social connection model of shared responsibility for improving epistemic conditions of participation in social practices. Through the articulation of a new interactionism and polyphonic contextualism, the book develops a sustained argument about the role of the imagination in mediating social perceptions and interactions. It concludes that only through the cultivation of practices of resistance can we develop a social imagination that can help us become sensitive to the suffering of excluded and stigmatized subjects. Drawing on Feminist Standpoint Theory and Critical Race Theory, this book makes contributions to social epistemology and to recent discussions of testimonial and hermeneutical injustice, epistemic responsibility, counter-performativity, and solidarity in the fight against racism and sexism.

In the era of information and communication, issues of misinformation and miscommunication are more pressing than ever. Epistemic injustice - one of the most important and ground-breaking subjects to have emerged in philosophy in recent years - refers to those forms of unfair treatment that relate to issues of knowledge, understanding, and participation in communicative practices. The Routledge Handbook of Epistemic Injustice is an outstanding reference source to the key topics, problems and debates in this exciting subject. The first collection of its kind, it comprises over thirty chapters by a team of international contributors, divided into five parts: Core Concepts Liberatory Epistemologies and Axes of Oppression Schools of Thought and Subfields within Epistemology Socio-political, Ethical, and Psychological Dimensions of Knowing Case Studies of Epistemic Injustice. As well as fundamental topics such as testimonial and hermeneutic injustice and epistemic trust, the Handbook includes chapters on important issues such as social and virtue epistemology, objectivity and objectification, implicit bias, and gender and race. Also included are chapters on areas in applied ethics and philosophy, such as law, education, and healthcare. The Routledge Handbook of Epistemic Injustice is essential reading for students and researchers in ethics, epistemology, political philosophy, feminist theory, and philosophy of race. It will also be very useful for those in related fields, such as cultural studies, sociology, education and law.

"A theory in the flesh means one where the physical realities of our lives all fuse to create a politic born of necessity," writes activist Cherrie L. Moraga. This volume of new essays stages an intergenerational dialogue among philosophers to introduce and deepen engagement with U.S Latinx and Latin American feminist philosophy, and to explore their "theories in the flesh." It explores specific intellectual contributions in various topics in U.S. Latinx and Latin American feminisms that stand alone and are unique and valuable; analyzes critical contributions that U.S. Latinx and Latin American interventions have made in feminist thought more generally over the last several decades; and shows the intellectual and transformative value of reading U.S Latinx and Latin American feminist theorizing. The collection features a series of essays analyzing decolonial approaches within U. S. Latinx and Latin American feminist philosophy, including studies of the functions of gender within feminist theory, everyday modes of resistance, and methodological questions regarding the scope and breadth of decolonization as a critical praxis. Additionally, essays examine theoretical contributions to feminist discussions of selfhood, narrativity, and genealogy, as well as novel epistemic and hermeneutical approaches within the field. A number of contributors in the book address themes of aesthetics and embodiment, including issues of visual representation, queer desire, and disability within U. S. Latinx and Latin American feminisms. Together, the essays in this volume are groundbreaking and powerful contributions in the fields of U.S Latinx and Latin American feminist philosophy.

Title: Historica relacion del Reyno de Chile y de las misiones y ministerios que eje rcita en e l la Compan ia de Jesus ... Reimpresa con una introduccion biogra fica ... por J. T. Medina.Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The HISTORY OF CENTRAL & SOUTH AMERICA collection includes books from the British Library digitised by Microsoft. Titles in this collection provide cultural, statistical, commercial, chronological and geo-economic histories of Central and South America. This series also includes texts, reports, letters, and illustrated and interpretive histories of indigenous peoples, and the natural and built environments that have fascinated historians for centuries. Along with written records, the collection features transcribed oral histories and traditions spanning the range of cultures and civilisations in the southern hemisphere. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Ovalle, Alonso; Medina, Jose Medina.; 1888 2 tom.; 8 . 9781.g.12.

This book explores the epistemic side of oppression, focusing on racial and sexual oppression and their interconnections. It elucidates how social insensitivities and imposed silences prevent members of different groups from interacting epistemically in fruitful ways-from listening to each other, learning from each other, and mutually enriching each other's perspectives. Medina's epistemology of resistance offers a contextualist theory of our complicity with epistemic injustices and a social connection model of shared responsibility for improving epistemic conditions of participation in social practices. Through the articulation of a new interactionism and polyphonic contextualism, the book develops a sustained argument about the role of the imagination in mediating social perceptions and interactions. It concludes that only through the cultivation of practices of resistance can we develop a social imagination that can help us become sensitive to the suffering of excluded and stigmatized subjects. Drawing on Feminist Standpoint Theory and Critical Race Theory, this book makes contributions to social epistemology and to recent discussions of testimonial and hermeneutical injustice, epistemic responsibility, counter-performativity, and solidarity in the fight against racism and sexism.

An introduction to the philosophy of language for undergraduates Key Concepts in Philosophy is a series of concise, accessible and engaging introductions to the core ideas and subjects encountered in the study of philosophy. Specially written to meet the needs of students and those with an interest in, but little prior knowledge of, philosophy, these books open up fascinating, yet sometimes difficult ideas. The series builds to give a solid grounding in philosophy and each book is also ideal as a companion to further study. Inquiry into the nature and purpose of language has long been a central concern of Western philosophy, within both the analytic, Anglo-American tradition, and its Continental counterpart. Language: Key Concepts in Philosophy explains and explores the principal ideas, theories and debates in the philosophy of language, providing a clear and authoritative account of the discipline. The text covers the work on language of the major philosophers in both traditions, including Frege, Wittgenstein, Austin, Quine, Davidson, Heidegger, Gadamer, Derrida and Butler. The book equips readers with the requisite philosophical tools to get to grips with central concepts and key issues, and raises challenging questions students can then explore on their own. Coverage of each issue provides the reader with a full account of the state of the question and a thorough assessment of the arguments entailed in the available literature on that subject.