Apprentices to Genius: A tribute to Solomon H. Snyder, a volume in the Advances in Pharmacology series, presents a tribute to Dr. Solomon H. Snyder, highlighting chapters submitted from a broad range of his students. It covers many different areas of neuroscience and pharmacology, with this volume exploring how receptor binding and drug discovery, the emerging role of glutamate in the pathophysiology of mental illness, nitric oxide signaling in neurodegeneration and cell death, carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets, the regulation of mitochondrial functions by TSPO, clozapine and its translational investigation, and more.

N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan 's disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.

Each volume of "Advances in Pharmacology" provides a collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.;It updates anaesthesiologists and basic scientists on new aspects of anaesthesia and cardiovascular disease as it pertains not only to the mechanisms of anesthetic action in the normal muscle, but also in the presence of a variety of conditions and diseases such as cardiac ischemia, vascular disorders and cerebral injury.;The book gives the basic cardiac effects of anaesthetic along with information on the normal and ischemic processes controlling or affecting cardiac function, and contains the most recent experimental observations and hypotheses with emphasis on cardiovascular effects of anaesthetics and the mechanisms that may be involved in normal and pathophysiological states. It discusses the effects of anaethesia on reflex regulation along with the major circulatory effects of chronic hypertension, and presents a wide variety of the latest methodologies, from human studies to subcellular anaesthetic targets. The text also provides original presentations and interpretat

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.
Key Features
* This volume includes reviews on some of the hottest topics in pharmacology, including:
* Multidrug resistance and the "MDR"1 gene in gene therapy
* Regulation of calcium channels in epithelial cells
* Gene therapy and vascular disease
* Potential therapeutic applications for Heparin
* Calcium channel blockers
* Antithrombotic agents
* Regulation of potassium channels in epithelial cells

Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. For easy reference, this volume provides a cumulative subject index covering Volumes 25-44.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Drug-Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug-drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug-drug interactions, the prediction of drug-drug interaction potential of new drugs, and the avoidance of clinically significant drug-drug interaction in patients.
Key Features
* Provides useful references on the science of drug-drug interactions
* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
* Contains original data from academic and industrial laboratories
* Presents an overview of regulatory agency positions

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan's disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.

This book reviews the recent rapid development of functional neuroimaging techniques and their implications for child psychiatry. It is unique in that it focuses on children and integrates brain mapping with genetics and behavioral testing, an interface that is likely to become fundamental to functional neuroimaging. This invaluable reference will help clinicians and investigators to:

• Understand the mechanisms of childhood psychiatric disorders through imaging
• Decide the most appropriate technique for their purposes with respect to technology, experimental design, data analysis, and ethical considerations
• Appreciate the role of molecular genetics and neuropsychology in planning brain imaging studies. Set against an overview of normal behavioral and cognitive development, the text includes a description of new brain imaging strategies and the application of imaging techniques used on adults to children. Linking the latest findings from neuroimaging to neurophysiological models, this book is an essential resource for researchers and clinicians concerned with neurodevelopmental disorders.

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Neurology, Psychiatry, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Hypnosis, confabulation, source amnesia, flashbulb memories, repression--these and numerous additional topics are explored in this timely collection of essays by eminent scholars in a range of disciplines. This is the first book on memory distortion to unite contributions from cognitive psychology, psychopathology, psychiatry, neurobiology, sociology, history, and religious studies. It brings the most relevant group of perspectives to bear on some key contemporary issues, including the value of eyewitness testimony and the accuracy of recovered memories of sexual abuse.

The distinguished contributors to this volume explore the full range of biological phenomena and social ideas relevant to understanding memory distortion, including the reliability of children's recollections, the effects of hypnosis on memory, and confabulation in brain-injured patients. They also look into the activity and role of brain systems, cellular bases of memory distortion, and the effects of emotion and trauma on the accuracy of memory. In a section devoted to the social aspects of memory distortion, additional essays analyze the media's part in distorting social memory, factors influencing historical reconstruction of the collective past, and memory distortion in religion and other cultural constructs. Daniel Schacter launches the collection with a history of psychological memory distortions. Subsequent highlights include new empirical findings on memory retrieval by a pioneer in the field, some of the foremost research on computational models, studies of the relationship between emotion and memory, new findings on amnesia by a premier neuroscientist, and reflections on the power of collective amnesiain U.S. history, the Nazi Holocaust, and ancient Egypt.