|
Showing 1 - 22 of
22 matches in All Departments
Mutual Conformational Adaptation of Both Ligand and Receptor in
Antitumor Drug-DNA Complexes.- DNA Drug Interactions studied with
Polarized Light Spectroscopy: the DAPI Case.- Drug-DNA Recognition:
Sequence Specificity of the DNA Minor Groove Binder Berenil.-
Binding of Minor Groove Ligands to Short DNA Segments: Berenil
Complexed with d(GCAATTGC)2 and d(GCTTAAGC)2.- The Sequence
Specificity of Damage Caused by [125I]-Labelled Hoechst 33258 and
UV/IodoHoechst 33258 in Intact Cells and in Cloned Sequences of
Purified DNA which differ by a Small Number of Base Substitutions.-
Structure and Dynamics of a [1:1] Drug-DNA Complex: Analysis of 2D
NMR Data Using Molecular Mechanics and Molecular Dynamics
Calculations.- Determination of Distamycin-A Binding Modes by NMR.-
Molecular Mechanisms of DNA Sequence Recognition by Groove Binding
Ligands: Biochemical and Biological Consequences.- Daunomycin
Binding to DNA: from the Macroscopic to the Microscopic.- In Vitro
Transcription Analysis of the Sequence Specificity of Reversible
and Irreversible Complexes of Adriamycin with DNA.- Quantitative
Footprinting Analysis of the Actiomycin D-DNA Interaction.-
Structural Requirements for DNA Topoisomerase II Inhibition by
Anthracyclines.- Thermodynamic Studies of Amsacrine Antitumor
Agents with Nucleic Acids.- Kinetic and Equilibrium Binding Studies
of a Series of Intercalating Agents that Bind by Threading a
Sidechain Through the DNA Helix.- Aminoacyl-Anthraquinones:
DNA-Binding and Sequence Specificity.- The Molecular Basis of
Specific Recognition Between Echinomycin and DNA.-
Bis-Pyrrolecarboxamides Linked to Intercalating Chromophore
Oxazolopyridocarbazole (OPC): Properties Related to the Selective
Binding to DNA at Rich Sequences.- Parallel-Stranded Nucleic Acids
and their Interaction with Intercalating and Groove Binding Drugs.-
Design of Bifunctional Nucleic Acid Ligands.- Sequence-Specific
Recognition and CLeavage of Duplex DNA by Derivatized
Oligonucleotides.- Bis(Platinum) Complexes. Chemistry, Antitumor
Activity and DNA-Binding.- Interaction of Calicheamicin with DNA.-
The Effects of Ligand Structure on Binding Mode and Specificity in
the Interaction of Unfused Aromatic Cations with DNA.- Modulation
of Protein-DNA Interactions by Intercalating and Nonintercalating
Agents.- Antitumor Antibiotics Endowed with DNA Sequence
Specificity.- Cationic Porphyrin-DNA Complexes: Specificity of
Binding Modes.- Complementary Studies on Sequence Specificity in
DNA-Antitumor Drugs Interactions.- Uranyl Photofootpring. DNA
Structural Changes upon Binding of Mithramycin.- Characteristics of
Noncovalent and Covalent Interactions of (+) and (-)
Anti-Benzo[a]pyrene Diol Epoxide Stereoisomers of Different
Biological Activities with DNA.- Aflatoxin-DNA Binding and the
Characterization of Aflatoxin B1-Oligodeoxynucleotide Adducts by 1H
NMR Spectroscopy.- Sequence Specific Isotope Effects on the
Cleavage of DNA by Radical-Generating Drugs.- Quinolone-DNA
Interaction: How a Small Drug Molecule Acquires High DNA Binding
Affinity and Specificity.- Mechanisms of DNA Sequence Selective
Modifications by Alkylating Agents.- Contrasting Mechanisms for the
Sequence Recognition of DNA by(+)- and (-)-CC-1065.- Course of
Recognition and Covalent Reactions Between Mitomycin C and DNA:
Sequence Selectivity of a Cross-Linking Drug.- Triplex Forming
Oligonucleotide Reagents: Rationalization of DNA Site Selectivity
and Application in a Pharmaceutical Context.- Experimental Proofs
of a Drug's DNA Specificity.
The Twenty Sixth Jerusalem Symposium reflected the high standards
of these distinguished scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
reaction dynamics in clusters and condensed phases, which
constitutes a truly interdisciplinary subject of central interest
in the areas of chemical dynamics, kinetics, photochemistry and
condensed matter chemical physics. The main theme of the Symposium
was built around the exploration of the interrelationship between
the dynamics in large finite clusters and in infinite bulk systems.
The main issues addressed microscopic and macroscopic sol vation
phenomena, cluster and bulk spectroscopy, photodissociation and
vibrational predissociation, cage effects, interphase dynamics,
reaction dynamics and energy transfer in clusters, dense fluids,
liquids, solids and biophysical systems. The interdisciplinary
nature of this research area was deliberated by intensive and
extensive interactions between modern theory and advanced
experimental methods. This volume provides a record of the invited
lectures at the Symposium.
The Fifteenth Jerusalem Symposium reflected the high standards of
the former international scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
intramo lecular dynamics, a subject of central interest for
theoreticians, che mists and biologists. During the last two
decades, there has been remarkable pro gress in our understanding
of time dependent phenomena. The development and application of the
modern techniques of quantum mechanics and sta tistical mechanics
to excited-state dynamics and to chemical and biophy sical systems
constitutes a fast developing current research area. The main theme
of the Symposium was built around a conceptual framework for the
elucidation of photophysical and photochemical phenomena in atoms,
molecules, van der Waals complexes and clusters, condensed phases,
poly mers and biological supermolecules. The interdisciplinary
nature of this research field was deliberated by intensive and
extensive interactions between scientists from different
disciplines and between theory and experiment. This volume provides
a record of the invited lectures at the Symposium."
The 25th Jerusalem Symposium represents a most significant
highlight in the development and history of these meetings. Living
within the decimal system we have celebrated with much pleasure the
lath and the 20th Jerusalem Symposia. With this one we experience a
feeling of particular satisfaction because 25 years is different
from, is more than, two decades and a half. It is a quarter of a
century. It seems thus as if we have changed the dimension of our
endeavour. In no way do we loose the sense of modesty with respect
to the significance of these meetings. For the organizers, however,
they do represent a continuity of efforts which we feel happy to
have been able to carry out. At this occasion it seems useful to
say a few words about the origin of the Jerusalem Symposia and to
recall the name of a colleague who played an essential role in
their creation and has been a most efficient and devoted co
organizer of the seven first of them. This was Professor Ernst
Bergmann, one of the most distinguished founders of Israeli Science
and a world famous physico-organic chemist.
The Symposium on "Transport through Membranes : Carriers. Channels
and Pumps" Inaugurates the third decade of the Jerusalem Symposia.
It enlarges substantially their conceptual scope by Introducing a
new subject not treated there previously. In fact. It Is a topic
particularly well suited for the general object of these
International meetings which Is to reassemble In an exhaustive
Interdisciplinary discussion chemists. physicists and biologists.
theoreticians and experimentalists. The main theme of the Symposium
was the presentation and evaluation of the most up-to-date data on
the structural and dynamic aspects of transport through membranes
within the three main pathways: through carriers. channels and
pumps. This goal was fully achieved thanks to the participation of
a most outstanding assembly of world's experts In the field. We
wish to thank Madame Pullman. the real organizer and mainspring of
this meeting. for having composed a most exciting and excellent
program and for carrying It out successfully. As the twenty
preceding ones this Symposium was held under the auspices of the
Israel Academy of Sciences and Humanities and the Hebrew University
of Jerusalem. It was sponsored by the Instltut de Blologle Physlco
Chimique. Fondatlon Edmond de Rothschild of Paris. We wish to
express once again our gratitude to the Baron Edmond de Rothschild
for his constant and generous support which makes this continuous
endeavour possible.
The Twenty Fourth Jerusalem Symposium reflected the high standards
of these distinguished scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
mode selective chemistry, which constitutes a truly
interdisciplinary subject of central interest in the areas of
chemical physics, photochemistry and photobiology. The main theme
of the Symposium was built around the exploration of the
possibility and conditions for non-statistical reaction dynamics in
molecules, van der Waals molecules, clusters and condensed phases.
The main issues addressed photoselective and coherent excitation
modes, bottlenecks for intramolecular vibrational energy
redistribution, the consequences of the internal structure of
many-atom systems and of rotational vibrational level structure for
intramolecular dynamics, bond selective photodissociation,
ultrafast chemical clocks for energy disposal, coherent control of
photochemical reactions and nonstatistical unimolecular reaction
dynamics. The interdisciplinary nature of this research area was
deliberated by intensive and extensive interactions between theory
and experiment. This volume provides a record of the invited
lectures at the Symposium."
Gathering together a number of experts in the world, the 27th
Jerusalem Symposium was devoted to the theme of the modelling of
biomolecular structures and mechanisms. As a result of recent
growth in both importance and audience, the papers contained in
this volume present an evaluation of the status of the present
knowledge in this field. The main topics covered by this year's
Symposium include nucleic acids and their interactions, proteins
and their interaction, membranes and their interactions, enzymatic
processes and the pharmacological and medical aspects of these
subjects. Readers should benefit from the interdisciplinary
approach which provides coverage of both theoretical and
experimental advances.
Proceedings of the Nineteenth Jerusalem Symposium in Quantum
Chemistry and Biochemistry, held in Jerusalem, Israel, May 5-8,
1986
The Twenty Sixth Jerusalem Symposium reflected the high standards
of these distinguished scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
reaction dynamics in clusters and condensed phases, which
constitutes a truly interdisciplinary subject of central interest
in the areas of chemical dynamics, kinetics, photochemistry and
condensed matter chemical physics. The main theme of the Symposium
was built around the exploration of the interrelationship between
the dynamics in large finite clusters and in infinite bulk systems.
The main issues addressed microscopic and macroscopic sol vation
phenomena, cluster and bulk spectroscopy, photodissociation and
vibrational predissociation, cage effects, interphase dynamics,
reaction dynamics and energy transfer in clusters, dense fluids,
liquids, solids and biophysical systems. The interdisciplinary
nature of this research area was deliberated by intensive and
extensive interactions between modern theory and advanced
experimental methods. This volume provides a record of the invited
lectures at the Symposium.
One of the central problems in the study of the mechanism of
DNA-ligand interactions is the existence and nature of sequence
specificity with respect to the base pairs of DNA. The presence of
such a specificity could be of particular significance because it
might possibly mean the involvement of specific genes in the
effectiveness of the different drugs. The elucidation of the
factors responsible for the specificity could then be important for
the development of compounds susceptible to contribute to the
control of gene expression and also to the development of
rationally conceived, improved new generations of effective and
specific chemotherapeutic agents. Important recent achievements,
experimental and theoretical, in the analysis of such sequence
specificities open prospects for possible rapid progress in this
field. The 23rd Jerusalem symposium was devoted to the exploration
of these recent achievements in relation to many types of ligand,
with special emphasis on antitumor drugs. All major types of
interaction, intercalation, groove binding, covalent linking,
coordination, have been considered. So was also the effect of the
interaction on the structure and properties of the nucleic acids
and the relationship between the interaction and biological or
pharmacological activities. We feel that this Volume presents a
relatively complete up-to-date account of the state of the art in
this important field of research.
The 25th Jerusalem Symposium represents a most significant
highlight in the development and history of these meetings. Living
within the decimal system we have celebrated with much pleasure the
lath and the 20th Jerusalem Symposia. With this one we experience a
feeling of particular satisfaction because 25 years is different
from, is more than, two decades and a half. It is a quarter of a
century. It seems thus as if we have changed the dimension of our
endeavour. In no way do we loose the sense of modesty with respect
to the significance of these meetings. For the organizers, however,
they do represent a continuity of efforts which we feel happy to
have been able to carry out. At this occasion it seems useful to
say a few words about the origin of the Jerusalem Symposia and to
recall the name of a colleague who played an essential role in
their creation and has been a most efficient and devoted co
organizer of the seven first of them. This was Professor Ernst
Bergmann, one of the most distinguished founders of Israeli Science
and a world famous physico-organic chemist.
Gathering together a number of the best experts in the world, the
27th Jerusalem Symposium was devoted to the theme of the modelling
of biomolecular structures and mechanisms. As a result of recent
growth in both importance and audience, the papers contained in
this volume present a thorough evaluation of the status of the
present knowledge in this field. The main topics covered by this
year's Symposium include nucleic acids and their interactions,
proteins and their interaction, membranes and their interactions,
enzymatic processes and the pharmacological and medical aspects of
these subjects. Readers will benefit from the interdisciplinary
approach which provides an extensive coverage of both theoretical
and experimental advances.
The Twenty Fourth Jerusalem Symposium reflected the high standards
of these distinguished scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
mode selective chemistry, which constitutes a truly
interdisciplinary subject of central interest in the areas of
chemical physics, photochemistry and photobiology. The main theme
of the Symposium was built around the exploration of the
possibility and conditions for non-statistical reaction dynamics in
molecules, van der Waals molecules, clusters and condensed phases.
The main issues addressed photoselective and coherent excitation
modes, bottlenecks for intramolecular vibrational energy
redistribution, the consequences of the internal structure of
many-atom systems and of rotational vibrational level structure for
intramolecular dynamics, bond selective photodissociation,
ultrafast chemical clocks for energy disposal, coherent control of
photochemical reactions and nonstatistical unimolecular reaction
dynamics. The interdisciplinary nature of this research area was
deliberated by intensive and extensive interactions between theory
and experiment. This volume provides a record of the invited
lectures at the Symposium."
Colloque Weyl I was convened in June 1963 at the Catholic
University of Lille to commemorate one hundred years of the study
of metal-ammonia solutions. This memorable event, which involved a
"single-particle excitation," inspired Gerard Lepoutre to assemble
an international group of physicists and chemists to discuss the
nature of metal-ammonia solutions. Colloque Weyl II, which took
1969, was initiated as a place at Cornell Universtiy, Ithaca, N.Y.
in June "cooperative interaction" between M. J. Sienko, J. L. Dye,
J. J. Lagowski, G. Lepoutre and J. C. Thompson. That meeting made
it clear that Colloque Weyl should be continued in order to promote
the fruitful exchange of ideas set in motion at Lille and at
Cornell. Colloque Weyl III came into being as the result of a
resolution passed at the Cornell meeting, Tel-Aviv University being
the suggested site. The Organizing Committee consisted ofE. D.
Bergmann, J. Jortner, J. J. Lagowski, G. Lepoutre, U. Schindewolf
and M. J. Sienko, reflecting the international and
interdisciplinary aspects of the field.
The Seventeenth Jerusalem Symposium focused on dynamics on
surfaces, a subject of interest in the areas of chemistry, physics
and material sciences. The Symposium reflected the high standeds of
these distinguished scientific meetings, which convene yearly at
the Israel Academy of Sciences and Humanities to discuss a specific
topic in the broad area of quantum chemistry and biochemistry.
Molecule-surface dynamics constitutes a fast developing, current,
research area. The main theme of the Symposium was built around a
conceptual framework for the elucidation of the chemical and
physical aspects of atomic and molecular scattering off surfaces,
surface transport, surface reaction dynamics and radiative
interactions on surfaces. The interdisciplinary nature of this
research area was emphasized by intensive and extensive
interactions between scientists from different disciplines and
between theory and experiment. HeLd under the auspices of the
Israel Academy of Sciences and Humanities and the Hebrew University
of JerusaLem, the Seventeenth JerusaLem Symposium was sponsored by
the Institut de BioLogie Physico- Chimique (Fondation Edmond de
RothschiLd) of Paris. We wish to ex- press our deep thanks to Baron
Edmond de Rothschild for his continuous and generous support, which
makes him a true partner in this important endeavour. We would aLso
like to express our gratitude to the Admi- nistrative Staff of the
Israel Academy, and in particular to Mrs. AvigaiL Hyam, for the
efficiency and exceLLency of the LocaL arrangements.
th The 16 Jerusalem Symposium debated on one of the most im-
portant subjects of modern molecular biology: the nucleic acids. It
continued the tradition of gathering the most distinguished experts
in the field. Placed under the auspices of the Isra~l Acade~y of
Sciences and Humanities and the Hebrew University of Jerusalem it
was sponsored by the Institut de Biologie Physico-Chimique
(Fondation Edmond de Rothschild) of Paris and the Na~ional
Foundation for Cancer Research of Bethesda, U. S. A. We wish to
express our deep thanks to the Baron Edmond de Rothschild for his
continuous generosity which guarantees the perenniality of these
meetings and to the authorities of the National Foundation for
Cancer Research, in particular Mrs Tamara Salisbury and Dr.
Franklin Salisbury for having joined hands with us in this venture.
We wish also to express our gra~itude to the adminis- trative staff
of the Isra~l Academy and in particular to Mrs Avigail Hyam for the
efficiency and excellency of the local arrangements. Bernard
Pullman ,Joshua Jortner B. Pullman and J. Jortner (eds. ) ,
,Vucleic Acids the Vectors of Life, /-/5. (c) 1983 by D. Reidel
PuhlisliinK Company. BASE SEQUENCE. I-!E. LJY ":'TRIJCTIIR!: I\NI'
INTRIN
The Fifteenth Jerusalem Symposium reflected the high standards of
the former international scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and biochemistry. The topic at this year's Jerusalem Symposium was
intramo lecular dynamics, a subject of central interest for
theoreticians, che mists and biologists. During the last two
decades, there has been remarkable pro gress in our understanding
of time dependent phenomena. The development and application of the
modern techniques of quantum mechanics and sta tistical mechanics
to excited-state dynamics and to chemical and biophy sical systems
constitutes a fast developing current research area. The main theme
of the Symposium was built around a conceptual framework for the
elucidation of photophysical and photochemical phenomena in atoms,
molecules, van der Waals complexes and clusters, condensed phases,
poly mers and biological supermolecules. The interdisciplinary
nature of this research field was deliberated by intensive and
extensive interactions between scientists from different
disciplines and between theory and experiment. This volume provides
a record of the invited lectures at the Symposium."
The Twentieth Jerusalem Symposium reflected the high standards of
these distinguished scientific meetings which convene once a year
at the Israel Academy of Sciences and Humanities in Jerusalem to
discuss a specific topic in the broad area of quantum chemistry and
biochemistry. The Twentieth Jerusalem Symposium marked an
auspicious occasion. commemorating two decades of this scientific
endeavour. The topic at this year's Jerusalem Symposium was Large
Finite Systems which constitutes a truly interdisciplinary subject
of central interest in the broad areas of chemistry. physics.
astrophysics and biophysics. The main theme of the Symposium was
built around bridging the gap between molecular. surface and
condensed matter chemical physics. Emphasis was placed on the
interrelationship between the properties of large molecules. van
der Waals complexes and clusters. focusing on the structure.
dynamics of nuclear motion. quantum and thermodynamics size
effects. the nature of electronic states and excited-state
energetics and dynamics of large finite systems. The
interdisciplinary nature of these research areas was deliberated by
intensive and extensive interactions between scientists from
different disciplines and between theory and experiment. This
volume provides a record of the invited lectures at the Symposium.
The Symposium on "Transport through Membranes: Carriers. Channels
and Pumps" Inaugurates the third decade of the Jerusalem Symposia.
It enlarges substantially their conceptual scope by Introducing a
new subject not treated there previously. In fact. It Is a topic
particularly well suited for the general object of these
International meetings which Is to reassemble In an exhaustive
Interdisciplinary discussion chemists. physicists and biologists.
theoreticians and experimentalists. The main theme of the Symposium
was the presentation and evaluation of the most up-to-date data on
the structural and dynamic aspects of transport through membranes
within the three main pathways: through carriers. channels and
pumps. This goal was fully achieved thanks to the participation of
a most outstanding assembly of world's experts In the field. We
wish to thank Madame Pullman. the real organizer and mainspring of
this meeting. for having composed a most exciting and excellent
program and for carrying It out successfully. As the twenty
preceding ones this Symposium was held under the auspices of the
Israel Academy of Sciences and Humanities and the Hebrew University
of Jerusalem. It was sponsored by the Instltut de Blologle Physlco
Chimique. Fondatlon Edmond de Rothschild of Paris. We wish to
express once again our gratitude to the Baron Edmond de Rothschild
for his constant and generous support which makes this continuous
endeavour possible."
The Sixth International Congress on Quantum Chemistry convened at
the Campus of the Hebrew University. Jerusalem. Israel. on August
22-25. 1988. The International Congresses on Quantum Chemistry are
held under the auspices of the International Academy of Quantum
Molecular Science. Previous International Congresses on Quantum
Chemistry were held in France. Japan, the United States, Sweden and
Canada. These prestigious meetings provided a central contribution
to the important modern area of theoretical chemistry. The major
goals of the Sixth International Congress on Quantum Chemistry
were: A) To provide an overview of recent novel developments.
advances and directions of research in the broad area of quantum
molecular sciences. B) To establish strong interaction between the
theoretical discipline of quantum molecular sciences and
experiment. The general topics of the Sixth International Congress
were: a) Molecular Quantum Mechanics b) Many-Body Theory of
Molecular Structure c) Intermolecular Forces d) Complexes and
Clusters e) Molecular Spectroscopy f) Intramolecular Dynamics g)
Chemical Reactions h) Molecular Dynamics Simulations i)
Condensed-Phase Chemistry j) Surface Phenomena and Catalysis k)
Quantum Biochemistry 1) Biophysics The format of the Sixth
International Congress consisted of plenary lectures. symposia and
poster sessions. In the opening session of the Congress.
commemorative addresses were delivered in honoured memory of the
late Louis de Broglie and the late Robert S. Mulliken. Nobel Prize
Laureates and Members of the International Academy of Quantum
Molecular Science. A com memorative symposium was devoted to the
honoured memory of the late Massimo Simonetta."
The Twenty-Second Jerusalem Symposium reflected the high standards
of these distinguished scientific meetings, which convene once a
year at the Israel Academy of Sciences and Humanities in Jerusalem
to discuss a specific topic in the broad area of quantum chemistry
and 'biochemistry. The topic at this year's Jerusalem Symposium was
Perspectives in Photosynthesis, which constitutes a truly
interdisciplinary subject of central interest to biophysicists, and
biologists. chemists The main theme of the Symposium was built
around a conceptual framework for the acquisition, storage and
useful disposal of energy in photosynthetic reaction centres.
Emphasis was placed on the elucidation of primary charge separation
processes in photosynthesis and their exploration within the
framework of the electron transfer theory, on the interrelationship
between structural data, inter actions and electron transfer
kinetics, and on the role of protein dynamics in primary processes
in photosynthesis. The interdisciplinary nature of these research
areas was deliberated by intensive and extensive interactions
between scientists from different disciplines and between theory
and experiment. This volume provides a record of the invited
lectures at the Symposium."
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|