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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Molecular Basis of Specificity in Nucleic Acid-Drug Interactions - Proceedings of the Twenty-Third Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 14-17, 1990 (Paperback, Softcover reprint of the original 1st ed. 1990)
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Molecular Basis of Specificity in Nucleic Acid-Drug Interactions - Proceedings of the Twenty-Third Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 14-17, 1990 (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Jerusalem Symposia, 23
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One of the central problems in the study of the mechanism of
DNA-ligand interactions is the existence and nature of sequence
specificity with respect to the base pairs of DNA. The presence of
such a specificity could be of particular significance because it
might possibly mean the involvement of specific genes in the
effectiveness of the different drugs. The elucidation of the
factors responsible for the specificity could then be important for
the development of compounds susceptible to contribute to the
control of gene expression and also to the development of
rationally conceived, improved new generations of effective and
specific chemotherapeutic agents. Important recent achievements,
experimental and theoretical, in the analysis of such sequence
specificities open prospects for possible rapid progress in this
field. The 23rd Jerusalem symposium was devoted to the exploration
of these recent achievements in relation to many types of ligand,
with special emphasis on antitumor drugs. All major types of
interaction, intercalation, groove binding, covalent linking,
coordination, have been considered. So was also the effect of the
interaction on the structure and properties of the nucleic acids
and the relationship between the interaction and biological or
pharmacological activities. We feel that this Volume presents a
relatively complete up-to-date account of the state of the art in
this important field of research.
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