This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

The fraught tension between science and religion has loomed large in scholarship about the nineteenth century in Spain, especially given the prominence of the Catholic Church and the discoveries made by Wallace and Darwin. The struggle for epistemological superiority between these two discourses (science and religion) has served to overshadow certain corners of the cultural landscape that, though prominent sites of intellectual exploration in their day, have received comparatively less scholarly attention until recently. Fringe Discourses brings together a group of essays that seeks to restore a sense of the epistemological richness of nineteenth-century Spain. By exploring the relationship between epistemology, modernity, and subjectivity, these essays recover significant efforts by Spanish authors and intellectuals to explain human nature and their world, which seemed to be changing so radically before their eyes. In doing so the essays also reveal just how elastic the relationship was between science and pseudoscience, genius and quackery. Offering a veritable Wunderkammer, the authors collected here train their sights both on curious fields of study (from pogonolgy, the science of beards, to Spiritualism) and curiouser people (from a government spy on undercover assignment in Morocco dressed as a Moorish prince to a hypnotic huckster who dupes the queen regent). With other authors focusing on science fiction dystopias, mystical journeys, and anatomical symbology, Fringe Discourses reveals the Spanish nineteenth century for the intellectual Wild West it was.

This book constitutes the refereed proceedings of the 13th Colombian Conference on Computing, CCC 2018, held in Cartagena, Colombia, in September 2018. The 46 revised full papers presented were carefully reviewed and selected from 194 submissions. The papers deal with the following topics: information and knowledge management, software engineering and IT architectures, educational informatics, intelligent systems and robotics, human-computer interaction, distributed systems and large-scale architectures, image processing, computer vision and multimedia, security of the information, formal methods, computational logic, and theory of computation.

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

The incidence of skin cancer has risen rapidly in recent decades, and patients often present initially to practitioners in many different specialties. Because skin cancer can vary in clinical appearance, even dermatologists may experience difficulty in reaching a clinical diagnosis. For primary care physicians and physician extenders (physician assistants, nurses, and nurse practitioners), who have had very little or no formal training in dermatology, the task can be still more daunting. In this atlas, the authors set out to provide a practical resource that will help improve the 'visual vocabulary' of physicians and physician extenders, helping them identify lesions that should be biopsied. Hundreds of high-quality color images are included to assist the reader in the task of recognition and identification. All of the common cutaneous malignancies are illustrated, with a number of examples of each entity and of common mimickers. In addition, biopsy techniques and treatment options are presented in step-by step detail with the use of high resolution clinical images, and potential complications of treatment are discussed. This atlas is ideal for all providers who wish to sharpen their clinical acumen and gain confidence in identifying skin cancers.