This handbook provides a comprehensive overview of spatial configurations of language use and of language use in space. It consists of four parts. The first part covers the various practices of describing space through language, including spatial references in spoken interaction or in written texts, the description of motion events as well as the creation of imaginative spaces in storytelling. The second part surveys aspects of the spatial organization of face-to-face communication including not only spatial arrangements of small groups in interaction but also the spatial dimension of sign language and gestures. The third part is devoted to the communicative resources of constructed spaces and the ways in which these facilitate and shape communication. Part four, finally, is devoted to pragmatics across space and cultures, i.e. the ways in which language use differs across language varieties, languages and cultures.

Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. Founded in 1959 by its current editor, the series has moved from its initial focus on medicinal chemistry to a much wider scope. Today it encompasses all fields concerned with the development of new therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drug research. Invited authors present their biological, chemical, biochemical, physiological, immunological, pharmaceutical, toxicological, pharmacological and clinical expertise in carefully written reviews and provide the newcomer and the specialist alike with an up-to-date comprehensive list of prime references. Each volume of Progress in Drug Research contains fully cross-referencing indices which link the books together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.

Founded in 1959, the series has moved from its initial focus on medicinal chemistry to a much wider scope. This volume encompasses all fields concerned with the development of therapeutic drugs, and the elucidation of their mechanisms of action. When combined with the other volumes, it serves as a time-saving source of information for researchers concerned with drug research, and all those who need to keep abreast of ongoing developments in medicines.

Pragmatics of Fiction provides systematic orientation in the emerging field of studying pragmatics with/in fictional data. It provides an authoritative and accessible overview of this versatile new field in its methodological and theoretical richness. Giving center stage to fictional language allows scholars to review key concepts in sociolinguistics such as genre, style, voice, stance, dialogue, participation structure or features of orality and literariness. The contributors explore language as one of the creative tools to craft story worlds and characters by drawing on concepts such as regional, social and ethnic language variation, as well as multilingualism. Themes such as emotion, taboo language or impoliteness in fiction receive attention just as the challenges of translation and dubbing, the creation of past and future languages, the impact of fictional language on language change or the fuzzy boundaries of narratives. Each contribution, written by a leading specialist, gives a succinct, representative and up-to-date overview of research questions, theories, methods and recent developments in the field.

Alternative medicine: Herbal drugs and their critical appraisal - Part II.- Virus population dynamics, fitness variations and the control of viral disease: an update.- Applications of yeast in drug discovery.- Sympathetic nervous system and experimental diabetes: role of adrenal medullary hormones.- From outer to inner space: Traveling along a scientific career from astrochemistry to drug research.- Index Vol. 57.- Index of titles, Vol. 1-57.- Author and paper index, Vol. 1-57.

5-Hydroxytryptamine (5-HT)4 receptors and central nervous system function: An update.- Chemical teratogenesis in humans: Biochemical and molecular mechanisms.- Recent advances in potassium channel modulation.- Neuronal prostacyclin receptors.- Effects of NSAIDs on the kidney.- G protein coupled receptors as modules of interacting proteins: A family meeting.- Antifungal therapy, an everlasting battle.- Index - Sachverzeichnis - Table des matieres, vol. 49.- Index of titles - Verzeichnis der Titel - Index des titres vol. 1-49.- Author and paper index - Autoren- und Artikelindex - Index des auteurs et des articles, vol. 1-49.

This series was founded in 1959, and its focus has shifted from medicinal chemistry to a much wider scope. It now encompasses all fields concerned with the development of therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drugs research. Invited authors write reviews on the following fields: biology, chemistry, biochemistry, physiology, immunology, pharmacy, toxicology, pharmacology, and clinical aspects. The books are linked by indexes in each volume, forming an almost encyclopaedic work.

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson s disease, Huntington s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. "

This book examines the implementation of Education for Sustainable Development (ESD) programs in schools across Europe. It describes and analyzes how individual countries and the region as a whole have established teaching and learning methods to help students develop the competencies needed to be part of a sustainable society. Featuring chapters written by experts throughout Europe, the book first provides a general overview of ESD in various contexts, including the state-of-the-art of ESD theory and conceptual development; political and social analysis; the various concepts of ESD competencies; and teacher training. Next, the book details how ESD has been implemented in different European countries and regions, including: Sweden, Italy, Germany, Austria, Switzerland, Catalonia, Hungary, Finland, Norway, Denmark, Flanders, France, Cyprus, UK and the Netherlands. In recognition of education as a motor of change, the United Nations General Assembly declared a Decade of Education for Sustainable Development (2005-2014), calling for the integration of sustainable development into all aspects of education and learning. Inside this book, readers will find details on what has been done, as well as assessments of what more could be done, across Europe. It will help readers gain valuable insights into how to help students develop the knowledge, skills and values needed to shape a sustainable future.

Volume 47 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with inotropic steroids, with chemokines and their involvement in a wide range of inflam matory diseases, with the subclassification and nomenclature of ul- and Uz-adrenoceptors, with Chinese traditional medicine, with drug targets in the molecular pathogenesis of asthma, with cytokines and their therapeutic application in immunosuppression and immunostimulation, with alter native medicine and with the potential use of calcium blockers in psy chiatry. These reviews and the quotations of original articles provide the reader with valuable information on several new developments in the world-wide search for new and better medicines. In 1959, when the Editor started this series of monographs, it was his intention to help disseminate informa tion on the vast and fast growing domain of drug research. Already at that time,it was not possible to follow the major individual publications in this field, and the reader was thereby provided with a tool to keep abreast of the latest developments and trends. This goal remained unchanged over the last 37 years, and I believe that the reviews in PDR are useful to the non-specialist who can obtain an overview of a particular field of drug research in a relatively short time.

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in T bingen.

The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

The future of English linguistics as envisaged by the editors of Topics in English Linguistics lies in empirical studies which integrate work in English linguistics into general and theoretical linguistics on the one hand, and comparative linguistics on the other. The TiEL series features volumes that present interesting new data and analyses, and above all fresh approaches that contribute to the overall aim of the series, which is to further outstanding research in English linguistics.

U-50,488 and the K receptor. Part II: 1991-1998.- Quantitative structure-activity relationships of antihypertensive agents.- Combinatorial chemistry: Polymer supported synthesis of peptide and nonpeptide libraries.- From genome to drug - optimising the drug discovery process.- Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD.- Index Vol. 53.- Index of titles, Vol. 1-53.- Author and paper index, Vol. 1-53.

The Handbook of Historical Pragmatics provides an authoritative and accessible overview of this versatile new field in pragmatics devoted to a diachronic study of language use and human interaction in context. It covers all areas of historical pragmatics from grammaticalization theory to pragmatic entities, such as discourse markers, speech acts and politeness to individual discourse domains from scientific writing to literary discourse. Each contribution, written by a leading specialist, gives a succinct, representative and up-to-date overview of research questions, theories, methods and recent developments in the field.

Progress in Drug Research is a prestigious book series (founded in 1959) which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmalogical research. Each volume contains fully cross-referencing indexes which link the volumes together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.

Volume 50 in the series includes:

P.N. Kaul: Drug discovery: Past, present and future

M. Rohmer: Isoprenoid biosynthesis via the mevalonate -- independent route, a novel target for antibacterial drugs

G. Edwards and A.H. Weston: Endothelium, -derived hyperpolarizing factor -- a critical appraisal

R.W. Rockhold: Glutamatic involvement in psychomotor stimulant action

J.M. Colacino and K.A. Staschke: The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection

T.D. Johnson: Polyamines and cerebral ischemia

Nikolaus Seiler, Benoit Duranton and Francis Raul: The polyamine oxidase inactivator MDL 72527.- Zhi Hong and Craig E. Cameron: Pleiotropic mechanisms of ribavirin antiviral activities.- Jie Hong Hu and Charles Krieger: Protein phosphorylation networks in motor neuron death.- James O. Schenk: The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate.- Laszlo Prokai: Central nervous system effects of thyrotropin-releasing hormone and ist analogues: opportunities and perspectives for drug discovery and development.- David F. Horrobin: A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E).- Suprabhat Ray, Reema Rastogi and Atul Kumar: Current status of estrogen receptors

Jay A. Glasel: Drugs, the human genome, and individual-based medicine.- Vera M. Kolb: Herbal medicine of Wisconsin Indians.- Paul L. Skatrud: The impact of multiple drug resistance (MDR) proteins on chemotherapy and drug discovery.- John W. Ford, Edward B. Stevens, J. Mark Treherne, Jeremy Packer and Mark Bushfield: Potassium channels: Gene family, therapeutic relevance, high-throughput screening technologies and drug discovery.- David T. Wong and Frank P. Bymaster: Dual serotonin and noradrenaline uptake inhibitor class of antidepressants - Potential for greater efficacy of just hype?.- Satya P. Gupta: Advances in QSAR studies of HIV-1 reverse transcriptase inhibitors

S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture

This open access book reviews evidence and case studies on the effects of outdoor learning on teachers and learners. It shows how real-world learning outside the classroom contributes to unlocking the full potential of learners, demonstrating its benefits for academic learning, social competencies, personal and emotional development, psychological well-being, and physical activity and health. In addition, the book highlights how outdoor learning nurtures environmental awareness and helps learners to tackle current sustainability challenges. Its focus on high-quality learning makes it a unique contribution to the implementation of SDG 4. Aimed at lecturers at teacher training universities, teachers, professional educators, coaches, and multipliers who train staff of educational NGOs, as well as decision makers on all levels of education systems, this book is of interest to all those who seek a more in-depth understanding of the future of education.

Methods in Pragmatics provides a systematic overview of the different types of data, the different methods of data collection and data analysis used in pragmatic research. It offers authoritative and comprehensive surveys of the entire breadth of methods and methodologies. Part 1 covers introspectional, philosophical and cognitive pragmatics. Part 2 is devoted to experimental pragmatics, including discourse completion and dialogue construction tasks, role-plays and other production and comprehension tasks. Part 3 reviews observational pragmatics including ethnographic and discourse analytic methods, and part 4, finally, is devoted to corpus pragmatics including accounts of corpus compilation, annotation and data retrieval specific to pragmatic research. Each contribution provides a state-of-the-art account of the precise workings of one particular method, its applications in the relevant research literature as well as a critical assessment of its strengths and weaknesses and the type of pragmatic research questions for which it is most suitable.

Drawing on a wide range of fictional texts from Shakespeare and Austen to Game of Thrones and the lyrics of 'We Shall Overcome', this textbook shows how pragmatic analyses can uncover the performative elements that create and shape characters for an audience. By exploring fictional language, the book investigates different forms of interpersonal communication, such as politeness and impoliteness, as well as the nature of poetic language and the language of emotion. With exercises, discussion topics, suggestions for small-scale research projects and further reading, it shows just how fascinating a challenge fictional language can pose to pragmatics, and illustrates the richness of fictional language as a source of data for pragmatic research.

This Element outlines current issues in the study of the pragmatics of fiction. It starts from the premise that fictional texts are complex and multi-layered communicative acts which deserve attention in pragmatic research in their own right, and it highlights the need to understand them as cultural artefacts rich in possibilities to explore pragmatic effects and pragmatic theorising. The issues covered are (1) the participation structure of fictional texts, (2) the performance aspect of fictional texts, (3) the interaction between readers and viewers and the fictional texts, as well as (4) the pragmatic effects of drawing on indexical linguistic features for evoking ideologies in characterisation.

This book examines the implementation of Education for Sustainable Development (ESD) programs in schools across Europe. It describes and analyzes how individual countries and the region as a whole have established teaching and learning methods to help students develop the competencies needed to be part of a sustainable society. Featuring chapters written by experts throughout Europe, the book first provides a general overview of ESD in various contexts, including the state-of-the-art of ESD theory and conceptual development; political and social analysis; the various concepts of ESD competencies; and teacher training. Next, the book details how ESD has been implemented in different European countries and regions, including: Sweden, Italy, Germany, Austria, Switzerland, Catalonia, Hungary, Finland, Norway, Denmark, Flanders, France, Cyprus, UK and the Netherlands. In recognition of education as a motor of change, the United Nations General Assembly declared a Decade of Education for Sustainable Development (2005-2014), calling for the integration of sustainable development into all aspects of education and learning. Inside this book, readers will find details on what has been done, as well as assessments of what more could be done, across Europe. It will help readers gain valuable insights into how to help students develop the knowledge, skills and values needed to shape a sustainable future.

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer's disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.

Volume 39 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with polyamines as tumor markers; the histamine (H3)-receptor and its role as a general regulatory system; with cytokines as immunosti mulants and immunosuppressants as well as potential anticancer agents; with fibrinolysis and clinical use of thrombolytic agents; and with catechol O-methyltransferase and its inhibitors, which are of potential interest in the treatment of Parkinson's disease. An exten sive review on antihistamines (HI) provides an excellent survey of this area in drug research. In the 32 years that "Progress in Drug Research" has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and, last but not least, the review ers have all contributed greatly to the success of the series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.