Neurological applications of PET include using it to identify Alzheimer's Disease, including differentiating between other forms of Dementia, to show causes of seizures that were otherwise unclear, and to diagnose psychiatric disorders like Schizophrenia. Although other books on PET may have a chapter or section on neurological applications, this is the only comprehensive and up-to-date book on neurological PET. It reviews PET in neuroscience with particular emphasis on findings that indicate its potential for improving diagnosis and treatment in neurology and psychiatry. Improving the transfer of the huge scientific developments in brain PET into clinical care will produce tangible human benefit. To this end, NeuroPET focuses on practical and potentially clinically relevant issues and identify solid ground as well as open questions. In addition, the book includes major chapters on the methodological background, including tracer physiology and kinetic modeling, and a comprehensive literature review. Included in this extremely useful package is a CD-ROM that features video clips and interactive navigation in 3D data sets that illustrate the information contained in PET images in major neurological diseases and its potential to improve diagnosis and neurosurgical planning in brain tumors.

Neurological applications of PET include using itto identify Alzheimer's Disease, including differentiating between other forms of Dementia, to show causes of seizures that were otherwise unclear, and to diagnose psychiatric disorders like Schizophrenia. Although other books on PET may have a chapter or section on neurological applications, this is the only comprehensive and up-to-date book on neurological PET. It reviews PET in neuroscience with particular emphasis on findings that indicate its potential for improving diagnosis and treatment in neurology and psychiatry. Improving the transfer of the huge scientific developments in brain PET into clinical carewill produce tangible human benefit. To this end, "NeuroPET" focuses on practical and potentially clinically relevant issues and identify solid ground as well as open questions. In addition, the book includes major chapters on the methodological background, including tracer physiology and kinetic modeling, and a comprehensive literature review."

The series of workshops sponsored by the European Communities started with "Methodology of PET" at Hammersmith Hospital, London, in March 1984. This was followed by "Radiochemistry, Methodology and Standardization in PET" at the Service Hospitalier Frederic Joliot in Orsay, France, in March 1985. Both these meetings were, in the opinion of all participants, great successes, and it was agreed that such work shops should continue and be organized on the same basis. After these two workshops on the fundamentals of PET, time now is ripe to evaluate the clinical efficacy of PET investigations, and to discuss to what extend the information provided by this high technology and theoretical area has contributed to the understanding of disease mechanisms, leading to immediate clinical applications. As pointed out in the previous meetings, PET using short-lived radioisotopes produced in an on-line cyclotron is restricted to a few centers. Therefore, the topics studied so far were mainly of scientific interest and clinical problems were dealt with only marginally. Before this costly technique can be spread and new information made accessible to a broader clinical clientele, its clinical value must be demonstrat ed. So far, in the majority of studies, the central nervous system was the primary target organ, and PET has contributed a great deal to our understanding of brain physiology and pathology. Also on the heart, a substantial number of studies have been performed in various centers, but the application of PET to this organ is still somewhat limited."

Das vorliegende Buch enthalt die zum Teil erweiterten Referate eines Symposions in Kairo im November 1983 zum Thema "Par kinson pIus." Die Beitrage befaBten sich mit der Bedeutung extranigraler Himveranderungen und der mit ihnen assoziierten Himfunk tionsstorungen fur das Erscheinungsbild, den Verlauf und die therapeutische BeeinfluBbarkeit des Parkinson-Syndroms. Diese Problematik gewinnt mit der steigenden Zahllangzeit behandelter Parkinson-Kranker zunehmend an Bedeutung. Dies bestatigten auch die lebhaften Diskussionen, die sich an die ver schiedenen Beitrage anschlossen. Die Referate des Symposions gaben eine Standortbestimmung bezuglich der Kenntnisse uber dieses neue Feld der Parkinsonforschung. Themen fur weitere wissenschaftliche Untersuchungen und Ansatze fur neue zusatz liche Behandlungsverfahren wurden deutlich. Das Symposion war durch die Unterstutzung der Firma UCB moglich. Eine hervorragende Organisation, die den Herren Dr. THIEDE und HANSEN und ihren Mitarbeitem zu danken ist, ermog lichte emen intensiven wissenschaftlichen Gedankenaustausch und unvergeBliche Eindrucke von einem faszinierenden Land. Frankfurt, im Juni 1984 P.-A. FISCHER Inhaltsverzeichnis Parkinson pIus - Einleitung und Definition P.-A. FISCHER ........... . 1 Ergebnisse der medikamentosen Parkinson-Therapie. Modiflzierende und limitierende Faktoren P.-A. FISCHER, E. SCHNEIDER und P. JACOBI (Mit 3 Abbildungen) . . . . . . . . . . . . . . . 4 Klinische Neuropathologie des Parkinson-Syndroms - Proteintyp und Dopamintyp der Demelaninisierung H. JACOB und T. KAWAGOE (Mit 8 Abbildungen) 18 Extranigrale Himveranderungen beim Parkinson-Syndrom."