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The attack of atrial fibrillation experienced by President Bush of
the United States attracted more attention from the general public
to atrial fibrillation than ever before. Also, there is a growing
body of knowledge of the pathophysiologic mechanism, the pathology
and epidemiology, and especially of the thrombo-embolic
complications of this arrhythmia, which is responsible for a
renewed interest of the clinician in this very common human
arrhythmia. These new perspectives on atrial fibrillation were
presented during a conference on Atrial Fibrillation, a Treatable
Disease?', organized on May 7, 1992, in Amsterdam, the Netherlands.
Atrial fibrillation is not the prerogative of the cardiologist
only. Many practitioners from other areas in health care, in
particular general physicians, internists and neurologists, are
faced with this arrhythmia and its untoward consequences. This book
bridges the gap between theory, experiment and the clinic. Emphasis
is therefore on the selection of the optimal approach, including
pharmacotherapy, catheter ablation, pacemaker and surgical therapy,
based on the current scientific insights in the mechanism and
prevention of atrial fibrillation.
A unique overview of all major angiographic lipid intervention
trials, presented by their principal investigators. Basic
mechanisms and methodological aspects, including biochemical as
well as angiographic aspects, are discussed by experts in these
fields. A careful comparison of all available data permits an
analysis to be made of what may currently be considered proved,
which aspects merit further investigation, and which hypotheses
should be rejected. Audience: Clinicians involved in the practice
of lipid lowering and investigators involved in lipid-lowering
clinical trials. Scientists involved in other areas of lipid
research and investigators conducting coronary angiographic trials
designed to study the influence of different interventions will
find a wealth of information and practical guidelines in this book.
In Groningen there has been a continuous investigation of
hypertrophic cardio myopathy for almost twenty years. Members of
this working-group have tried to study the many aspects of this
intriguing disease, and it is in this volume that they present
their recent results and current concepts (chapters 2, 3, 5 and 6).
A contribution from the Dutch interuniversity Institute of
Cardiology presenting a detailed account of evaluation by means of
radionuclide techniques completes the non-invasive picture of
cardiomyopathies (chapter 4). On July 6th, 1984, a symposium
entitled 'Recent views on hypertrophic cardio myopathy' was held at
the University Hospital Groningen. The main reason to organize this
meeting was the retirement of one of our working-group members,
namely E. van der Wall, as head of the cardiological department.
The speakers at the symposium presented their lectures based on
their contributions to this book. It is an honour for us to have
obtained their full cooperation for this book and for the
symposium. We are very grateful that this Groningen manifestation
could include the outstanding contributions of several well-known
experts from abroad. We there fore thank our colleagues Profs.
Epstein, Goodwin, Kaltenbach and Schulte for their spontaneous and
valuable cooperation (chapters 1, 7,8 and 9). Thanks to their
efforts especially, this book has acquired the international
character that the study of this subject deserves."
During the last decade we have witnessed a rapid expansion of our
knowledge of the role of the endothelium in the control of vascular
tone and hemostasis. In paricular, developments in molecular
biology have enabled us to understand its physiology in greater
detail. Furthermore, it is now clear that dysfunction of the
endothelium contributes to various cardiovascular diseases. This is
especially true for the coronary vascular bed. Development of
atherosclerosis, disturbed vasomotor tone in stable ischemic
syndromes, and the interaction of thrombocytes with the endothelium
in acute ischemic syndrome are all consequences of endothelium
dysfunction. Also, secondary changes in endothelial function have
been described, for instance in chronic heart failure. This
monograph reviews the present knowledge of the role of the
endothelium in the control of coronary flow. The authors lead the
reader through this topic starting at the basic physiology of
endothelial function and the principles of coronary flow
regulation. Next, the use of modern clinical techniques to evaluate
endothelial function such as positron emission tomography and
angioscopy are discussed. Subsequently, several pathophysiological
processes and the role of endothelium are addressed. Finally, the
interaction of various presently used cardiovascular drugs with the
endothelium is indicated. It is the combination of basic sciences
with clinical observations in this book which may be appreciated by
a large number of scientists and physicians active in the field of
cardiovascular disease. It is also this combination of different
disciplines which will determine future developments and new
avenues in pharmacotherapy involving the endothelium.
During the last decade we have witnessed a rapid expansion of our
knowledge of the role of the endothelium in the control of vascular
tone and hemostasis. In paricular, developments in molecular
biology have enabled us to understand its physiology in greater
detail. Furthermore, it is now clear that dysfunction of the
endothelium contributes to various cardiovascular diseases. This is
especially true for the coronary vascular bed. Development of
atherosclerosis, disturbed vasomotor tone in stable ischemic
syndromes, and the interaction of thrombocytes with the endothelium
in acute ischemic syndrome are all consequences of endothelium
dysfunction. Also, secondary changes in endothelial function have
been described, for instance in chronic heart failure. This
monograph reviews the present knowledge of the role of the
endothelium in the control of coronary flow. The authors lead the
reader through this topic starting at the basic physiology of
endothelial function and the principles of coronary flow
regulation. Next, the use of modern clinical techniques to evaluate
endothelial function such as positron emission tomography and
angioscopy are discussed. Subsequently, several pathophysiological
processes and the role of endothelium are addressed. Finally, the
interaction of various presently used cardiovascular drugs with the
endothelium is indicated. It is the combination of basic sciences
with clinical observations in this book which may be appreciated by
a large number of scientists and physicians active in the field of
cardiovascular disease. It is also this combination of different
disciplines which will determine future developments and new
avenues in pharmacotherapy involving the endothelium.
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