Encyclopedic in scope, Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 3: Environmental Manifestations of the Neurocardiovascular Systems draws deeply from clinical histories of thousands of patients. It focuses on clinical syndromes within the musculoskeletal, neurological, and cardiovascular systems with a special focus on vascular dysfunction and heart failure treatment. The book explores mechanisms of chemical sensitivity and chronic degenerative disease, their manifestations, diagnosis, and approaches to reverse dysfunction. It covers a wide variety of topics including environmental sensitivity due to external pollutants, environmental control for reducing total body load, pollutant damage to vascular perfusion, altered blood volume, fluctuations of oxygen extraction, effects of endocrine on the vascular system, effects of pollutants on myocardial cells, and mechanisms in vascular damage. The book also discusses in detail a wide variety of clinical manifestations including vasculitis, cardiac arrhythmias, cardiac metabolic syndrome, myocarditis, atherosclerosis, heart failure, urticaria, and anaphylaxis. Treatment for heart failure is also discussed. The third volume of a five-volume set, the book provides an essential resource for health care providers diagnosing and treating chemical sensitivity and chronic degenerative disease.

The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters into any discussion between doctor and patient.

A Homeostatic approach to Cure and Prevention for Researchers and Clinicians Working in Toxicology, Immunology, Neurology, and Internal Medicine

Reversibility of Chronic Degenerative Disease and Hypersensitivity, a four-part encyclopedia, offers a much different perspective on chronic degenerative disease, one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis. The first volume, Regulating Mechanisms of Chemical Sensitivity, demonstrates that one aspect common to chronic diseases is the disruption of systemic and cellular homeostasis. Environmental pollutants play a large role, along with the contributions of genetic and life style factors, in disrupting the self-regulating mechanisms built into our normally adaptive cells.

"As dyshomeostasis develops in the nervous system, causes should be found and removed before the metabolicinduced tissue changes take place and cause autonomous, irreversible fixednamed diseases to occur. Single and multiple chemicals in various doses either individually and/or in combinations can cause individual or multiorgan dysfunction of the endocrine system. The astute clinician must be aware of these factors in order to help the patient with hypersensitivity and/or chronic degenerative disease." Chapter 2

Drawing on a vast amount of data and clinical cases attended to by the authors in their own medical practices, this volume examines the complex relation that environmental pollution has with chronic degenerative diseases. It considers its impact on the body s vast communication networks and what excessive overload does to homeostatic mechanisms.

The authors factor in both general and specific environmental loads and how they alter and trigger genetic and non-genetic responses. Volume 1 begins with an overview of the physiologic basis of homeostasis, exploring various ways that the body deals with toxins and the networks it uses to communicate news of assault and makes provisions for adaptation. The text delves into the connective tissue matrix and considers vascular, neural, endocrine, and immune system responses to a variety of noxious assaults.

"Both innate and acquired immunity can be and are altered in individuals with chemical sensitivity and chronic degenerative disease. With pollutant overload changes can occur in the lymphatic channels, the lymph nodes, and lymph node egress as well as the lymphatic cells. Changes in mucosal function and the effects of the autonomic nervous system are evident with environmental pollutant overload." Chapter 3

Written by two very knowledgeable clinicians, it brings together research of the highest caliber and provides extensive discussions involving sophisticated biochemical, endocrine, and neural science. The text provides clinicians with the knowledge to understand the triggering and processes of degenerative diseases, so that they might develop more efficient treatment and prevention plans. The book also supplies the knowledge and perspective that can lead research to more effective treatments.

"The ground regulation system consisting of the connective tissue matrix, fibroblast, macrophages, mast cell, leukocyte, end capillary vessel and autonomic nerves, is a global information system for regulating the dynamics of homeostasis in the body. One s knowledge of this process must be the guide to move through the onset of early end-stage disease and, eventually, see the manifestations to fixed-named autonomous diseases. It is this knowledge that offers us the greatest potential for preventing and reversing early homeostatic dysfunction." Chapter 1