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This volume focuses on the potential use of probiotics in treating
metabolic disorders such as diabetes mellitus, metabolic acidosis,
and gut dysbiosis. Chapters draw an association between gut
microbiota and its diversity with metabolic diseases like diabetes,
obesity, related liver and gut disorders; gut-brain axis; increased
inflammation, and a compromised immune system resulting from these
manifestations and scope of intervention with probiotics. Special
attention is laid on describing the mechanisms of action of such
beneficial effects of probiotic administration. The ability of
probiotics to decrease metabolic endotoxemia by restoring the
disrupted intestinal mucosal barrier is also included. The volume
is a comprehensive compilation describing the scope and application
of probiotic and prebiotic therapy in treating metabolic disorders.
Readers will discover how probiotics are not just confined to the
microbiology industry but are showing promising results in the
medical and pharmaceutical sectors.
This volume focuses on the potential use of probiotics in treating
metabolic disorders such as diabetes mellitus, metabolic acidosis,
and gut dysbiosis. Chapters draw an association between gut
microbiota and its diversity with metabolic diseases like diabetes,
obesity, related liver and gut disorders; gut-brain axis; increased
inflammation, and a compromised immune system resulting from these
manifestations and scope of intervention with probiotics. Special
attention is laid on describing the mechanisms of action of such
beneficial effects of probiotic administration. The ability of
probiotics to decrease metabolic endotoxemia by restoring the
disrupted intestinal mucosal barrier is also included. The volume
is a comprehensive compilation describing the scope and application
of probiotic and prebiotic therapy in treating metabolic disorders.
Readers will discover how probiotics are not just confined to the
microbiology industry but are showing promising results in the
medical and pharmaceutical sectors.
Depression is one of the most prevalent and life-threatening forms
of mental illnesses associated with significant disability and
mortality. Stress can be considered as a major contribution for the
development of depressive disorder due to dysregulation of
HPA-axis. Although there are multiple pathways that are involved in
the pathogenesis of depression, the current antidepressants mainly
target monoaminergic pathway. However, therapeutic potential of
other pathways is still under investigation. Drugs targeting nitric
oxide, cytokines and kynurenine acid pathway might be the drugs of
choice in near future. Alzheimer's disease is a neurodegenerative
disorder with progressive dementia. Although basic research in
Alzheimer's disease has made remarkable progress in past 2 decades,
currently available drugs are able to improve cognitive symptoms
temporarily, and no treatment can reverse, stop, or even slow this
inexorable neurodegenerative process. This book dwells on the
recently unravelled pathogenetic hypothesis and therapeutics of
mental depression and Alzheimer's disease.
Diabetes mellitus produces numerous neurophysiological &
structural changes in the central and peripheral nervous system and
it further leads to development of neuropathic pain & moderate
cognitive deficits in diabetics. The etiology of diabetes
associated neuropathic pain & cognitive decline is
multifactorial and involves an underlying phenomenon of metabolic
memory. The concept of "metabolic memory," that is of diabetic
vascular stresses persisting even after stringent glucose control,
has been supported both in the laboratory and in the clinic in both
type 1 & type 2 diabetes. Therefore, "switching off" the
metabolic memory, could be an important strategy for the prevention
of diabetic neurological complications. Insulin alone reverses the
hyperglycemia but partially reversed neuropathic pain and memory
deficits in diabetic rats. However, insulin in combination with
tocotrienol, lycopene and sesamol not only attenuates the diabetic
condition but also reverses neuropathic pain and memory loss by
switching off various components of metabolic memory phenomenon.
Thus, these interventions may find clinical application in
therapeutic armamentarium of diabetics.
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